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CTHRC1  -  collagen triple helix repeat containing 1

Homo sapiens

Synonyms: Collagen triple helix repeat-containing protein 1, Protein NMTC1, UNQ762/PRO1550
 
 
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Disease relevance of CTHRC1

  • This study is to further characterize the clinical and functional relevance of CTHRC1 in melanoma and other human solid cancers [1].
  • CONCLUSIONS: Aberrant expression of CTHRC1 is widely present in human solid cancers and seems to be associated with cancer tissue invasion and metastasis [1].
 

High impact information on CTHRC1

 

Biological context of CTHRC1

  • Our data indicate that the novel molecule CTHRC1 is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration [3].
  • RESULTS: The 10 families provided evidence for linkage at both TCO and NMTC, with LOD scores of 1.56 and 2.85, respectively [4].
 

Anatomical context of CTHRC1

  • We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition [5].

References

  1. Aberrant expression of collagen triple helix repeat containing 1 in human solid cancers. Tang, L., Dai, D.L., Su, M., Martinka, M., Li, G., Zhou, Y. Clin. Cancer Res. (2006) [Pubmed]
  2. Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Durmus, T., Leclair, R.J., Park, K.S., Terzic, A., Yoon, J.K., Lindner, V. Gene Expr. Patterns (2006) [Pubmed]
  3. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Pyagay, P., Heroult, M., Wang, Q., Lehnert, W., Belden, J., Liaw, L., Friesel, R.E., Lindner, V. Circ. Res. (2005) [Pubmed]
  4. Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. McKay, J.D., Thompson, D., Lesueur, F., Stankov, K., Pastore, A., Watfah, C., Strolz, S., Riccabona, G., Moncayo, R., Romeo, G., Goldgar, D.E. J. Med. Genet. (2004) [Pubmed]
  5. Cthrc1 is a novel inhibitor of transforming growth factor-beta signaling and neointimal lesion formation. LeClair, R.J., Durmus, T., Wang, Q., Pyagay, P., Terzic, A., Lindner, V. Circ. Res. (2007) [Pubmed]
 
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