The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

TCO  -  Thyroid carcinoma, nonmedullary, with cell...

Homo sapiens

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TCO

  • We report both the identification of a new entity of FNMTC and the mapping of the responsible gene, named "TCO" (thyroid tumors with cell oxyphilia), in a French pedigree with multiple cases of multinodular goiter and NMTC [1].
  • METHODS: In 90 consecutive patients with a chronic coronary occlusion (TCO) of >2 weeks duration a recanalization was done [2].
  • METHODS: Sixty eight subjects (32 with emphysema, 36 healthy volunteers) had TCO measured twice at a mean (SD) interval of 7.5 (1.3) days [3].
  • Patients were considered to have pulmonary involvement when they had an interstitial syndrome on HRCT and a decrease of 20% in TCO/VE (transfer coefficient) on PFTs and/or an abnormal BAL (lymphocytosis higher than 20% and/or percentage of neutrophils higher than 10%) [4].
  • Interleukin 15 (IL-15 mRNA expression was detected in human colorectal cancer cells (Colo320, WiDr, TCO and DLD1) by the reverse transcriptase-polymerase chain reaction (RT-PCR) [5].
 

Psychiatry related information on TCO

  • During the second 6 month period, after controlling for antisocial personality disorder or PCL score and self-reported alcohol/drug use, the presence of a severe positive symptom, a TCO symptom, and an increase in TCO symptoms significantly increased the risk of aggressive behavior [6].
 

High impact information on TCO

  • TCO was mapped to chromosome 19p13.2 by linkage analysis with a whole-genome panel of microsatellite markers [1].
  • The only genes known to be directly involved in susceptibility to NMTC are MNG1 on chromosome 14q32 and TCO on chromosome 19q13.2, previously localized by us and others [7].
  • FTI-277 did not suppress the proliferation of BRAF-mutant cells (WiDr and TCO), but remarkably inhibited the growth of K-ras mutant cells (LoVo) [8].
  • Allelic loss in tumor samples was evenly distributed in both 19p13.2 and 2q21 regions, in accordance with the established linkage of TCO and NMTC1 for inherited tumors [9].
  • In the present work, we report the systematic screening of 14 candidate genes mapping to the region of linkage in affected TCO members, that led us to identify two novel variants respectively in exon 9 and exon 13 of TIMM44, a mitochondrial inner membrane translocase for the import in the mitochondria of nuclear-encoded proteins [10].
 

Biological context of TCO

  • These variants were co-segregating with the TCO phenotype, were not present in a large group of controls and were predicted to negatively affect the protein (exon 9 change) or the transcript (exon 13 change) [10].
  • The anion gap was calculated as [Na(+)] - [C1(-)] - [TCO (2)] [11].
  • RESULTS: The correlation coefficient between CCO and TCO was 0.92, no systematic bias was observed, and the relative error increased from 13.9% for a cardiac output of 21/min to 23.7% for an output of 101/min [12].
  • PURPOSE: To determine the effects of hypercapnia on warm and cold thermoregulatory responses and core cooling rates during mild cold stress, we examined the core temperature (TCO) thresholds for sweating, vasoconstriction and shivering, as well as core cooling rates of eight subjects immersed in 28 degrees C water under hypercapnic conditions [13].
  • RESULTS: The 10 families provided evidence for linkage at both TCO and NMTC, with LOD scores of 1.56 and 2.85, respectively [14].
 

Anatomical context of TCO

 

Other interactions of TCO

  • This study has examined the MNG1 and TCO loci to determine if they are similarly predisposing the Tas1 family to PTC [16].
  • In order to test the possibility of association between the GSTT1 and M1 null allele variant, and the risk of TCO (thyroid carcinoma with cell oxyphilia), a case-control study was carried out [17].
  • Reactions between aqueous solutions of K(+)L(-) (L = cyanoximate anions: TCO(-), PiPCO(-), and MCO(-)) and K(2)[MCl(4)] (M = Pd, Pt) resulted in the formation of ML(2) complexes [18].
 

Analytical, diagnostic and therapeutic context of TCO

  • Of the eight patients with pulmonary involvement, all had abnormal BAL, two had an interstitial syndrome on HRCT, two had decreased TCO/VE and three had positive J001X scintigraphy [4].
  • Kinetic and mechanistic details have been elucidated using UV/Vis, FTIR and TCO techniques [19].
  • TCO SB/VA was found significantly lower (P less than 0.005) in subjects with regional deficiency abnormalities (mostly perfusion abnormalities) [20].

References

  1. A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. Canzian, F., Amati, P., Harach, H.R., Kraimps, J.L., Lesueur, F., Barbier, J., Levillain, P., Romeo, G., Bonneau, D. Am. J. Hum. Genet. (1998) [Pubmed]
  2. Impaired acute collateral recruitment as a possible mechanism for increased cardiac adverse events in patients with diabetes mellitus. Werner, G.S., Richartz, B.M., Heinke, S., Ferrari, M., Figulla, H.R. Eur. Heart J. (2003) [Pubmed]
  3. Short term variability of single breath carbon monoxide transfer factor. Robson, A.G., Innes, J.A. Thorax (2001) [Pubmed]
  4. Imaging of pulmonary disease in rheumatoid arthritis using J001X scintigraphy: preliminary results. Goupille, P., Diot, P., Valat, J.P., Lemarie, E., Valat, C., Asquier, E., Delarue, A., Le Pape, A. European journal of nuclear medicine. (1995) [Pubmed]
  5. Interleukin-15 expression is associated with malignant potential in colon cancer cells. Kuniyasu, H., Oue, N., Nakae, D., Tsutsumi, M., Denda, A., Tsujiuchi, T., Yokozaki, H., Yasui, W. Pathobiology (2001) [Pubmed]
  6. The antecedents of aggressive behavior among men with schizophrenia: a prospective investigation of patients in community treatment. Hodgins, S., Hiscoke, U.L., Freese, R. Behavioral sciences & the law. (2003) [Pubmed]
  7. Genetic heterogeneity in familial nonmedullary thyroid carcinoma: exclusion of linkage to RET, MNG1, and TCO in 56 families. NMTC Consortium. Lesueur, F., Stark, M., Tocco, T., Ayadi, H., Delisle, M.J., Goldgar, D.E., Schlumberger, M., Romeo, G., Canzian, F. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  8. BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms. Ikehara, N., Semba, S., Sakashita, M., Aoyama, N., Kasuga, M., Yokozaki, H. Int. J. Cancer (2005) [Pubmed]
  9. Allelic loss on chromosomes 2q21 and 19p 13.2 in oxyphilic thyroid tumors. Stankov, K., Pastore, A., Toschi, L., McKay, J., Lesueur, F., Kraimps, J.L., Bonneau, D., Gibelin, H., Levillain, P., Volante, M., Papotti, M., Romeo, G. Int. J. Cancer (2004) [Pubmed]
  10. Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas. Bonora, E., Evangelisti, C., Bonichon, F., Tallini, G., Romeo, G. Br. J. Cancer (2006) [Pubmed]
  11. Serum anion gap in the differential diagnosis of metabolic acidosis in critically ill newborns. Lorenz, J.M., Kleinman, L.I., Markarian, K., Oliver, M., Fernandez, J. J. Pediatr. (1999) [Pubmed]
  12. Analysis of the accuracy of continuous thermodilution cardiac output measurement. Comparison with intermittent thermodilution and Fick cardiac output measurement. Jacquet, L., Hanique, G., Glorieux, D., Matte, P., Goenen, M. Intensive care medicine. (1996) [Pubmed]
  13. Hypercapnia lowers the shivering threshold and increases core cooling rate in humans. Johnston, C.E., Elias, D.A., Ready, A.E., Giesbrecht, G.G. Aviation, space, and environmental medicine. (1996) [Pubmed]
  14. Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. McKay, J.D., Thompson, D., Lesueur, F., Stankov, K., Pastore, A., Watfah, C., Strolz, S., Riccabona, G., Moncayo, R., Romeo, G., Goldgar, D.E. J. Med. Genet. (2004) [Pubmed]
  15. Familial thyroid cancer. Alsanea, O., Clark, O.H. Current opinion in oncology. (2001) [Pubmed]
  16. At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family. McKay, J.D., Williamson, J., Lesueur, F., Stark, M., Duffield, A., Canzian, F., Romeo, G., Hoffman, L. Eur. J. Endocrinol. (1999) [Pubmed]
  17. GSTT1 and M1 polymorphisms in Hürthle thyroid cancer patients. Stankov, K., Landi, S., Gioia-Patricola, L., Bonora, E., Volante, M., Papotti, M., Romeo, G. Cancer Lett. (2006) [Pubmed]
  18. First bivalent palladium and platinum cyanoximates: synthesis, characterization, and biological activity. Eddings, D., Barnes, C., Gerasimchuk, N., Durham, P., Domasevich, K. Inorganic chemistry. (2004) [Pubmed]
  19. Photooxidation of the phenylazonaphthol AO20 on TIO2: kinetic and mechanistic investigations. Galindo, C., Jacques, P., Kalt, A. Chemosphere (2001) [Pubmed]
  20. Regional pulmonary function in sarcoidosis. Weitzenblum, E., Moyses, B., Hirth, C., Meunier-Carus, J., Methlin, G., Oudet, P. Scandinavian journal of respiratory diseases. (1977) [Pubmed]
 
WikiGenes - Universities