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Gene Review:

Serpinb5 - serpin peptidase inhibitor, clade B...

Rattus norvegicus

Synonyms: Maspin, PI-5, Peptidase inhibitor 5, Pi5, Serpin B5

Umekita, Y. et al., Zucchi, I. et al.

Zucchi, Bini, Valaperta, Ginestra, Albani, Susani, Sanchez, Liberatori, Magi, Raggiaschi, Hochstrasser, Pallini, Vezzoni, Dulbecco,

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Disease relevance of Serpinb5

Rat maspin cDNA retrovirally introduced into highly metastatic Dunning AT3.1 rat prostate cancer cells did not suppress metastasis of these tumor cells in Copenhagen rats [1].
Two human prostate cancer cell lines, PC-3 and LNCaP, and two human prostatic carcinoma and two benign prostatic hyperplasia tissue samples contained maspin mRNA having an isoleucine to valine mutation at amino acid 319 [1].

High impact information on Serpinb5

Proteomic dissection of dome formation in a mammary cell line: role of tropomyosin-5b and maspin [2].
Rat maspin mRNA was detected in rat mammary gland, vagina, urinary bladder, thymus, small intestine, skin, ventral prostate, seminal vesicles, and thyroid but not in many other organs, such as heart, lung, liver, brain and kidney [1].
The deduced amino acid sequence of rat maspin was homologous to human maspin with 88% of the amino acids conserved [1].

References

Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells. Umekita, Y., Hiipakka, R.A., Liao, S. Cancer Lett. (1997) [Pubmed]
Proteomic dissection of dome formation in a mammary cell line: role of tropomyosin-5b and maspin. Zucchi, I., Bini, L., Valaperta, R., Ginestra, A., Albani, D., Susani, L., Sanchez, J.C., Liberatori, S., Magi, B., Raggiaschi, R., Hochstrasser, D.F., Pallini, V., Vezzoni, P., Dulbecco, R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SERPINB5	Canis lupus familiaris
SERPINB5	Gallus gallus
SERPINB5	Homo sapiens
SERPINB5	Macaca mulatta
Serpinb5	Mus musculus
SERPINB5	Pan troglodytes
serpinb5	Xenopus (Silurana) tropicalis

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