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Gene Review

Serpinb5  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: 1110036M19Rik, AI462524, AI646751, Maspin, PI-5, ...
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Disease relevance of Serpinb5

  • Recent studies of maspin in animal models strongly support maspin's role as an inhibitor against the growth of primary tumor sand the process of metastasis [1].
  • This evidence strongly suggests that the induction of apoptosis in maspin-overexpressing cells represents a major mechanism by which maspin inhibits breast tumor progression [1].
  • The maspin protein has tumor suppressor activity in breast and prostate cancers [2].
  • These studies showed that maspin expression decreased tumor growth, reduced osteolysis, and decreased angiogenesis [3].
  • Furthermore, the maspin-expressing tumors contained significant fibrosis and collagen staining, and exhibited a more glandular organization [3].

High impact information on Serpinb5


Chemical compound and disease context of Serpinb5


Biological context of Serpinb5


Anatomical context of Serpinb5

  • Such change results in an increased release of cytochrome c from mitochondria, thus the increased apoptosis in maspin-expressing cells [1].
  • Data from embryoid body formation studies indicated that the Mp(-/-) EBs had a disorganized, endodermal cell mass and lacked a basement membrane layer [10].
  • We showed that the embryonic ectoderm lineage was lost in the Mp(-/-) EBs, compared with that of the Mp(+/+) EBs [10].
  • Maspin was specifically expressed in the visceral endoderm after implantation; deletion of maspin interfered with the formation of the endodermal cell layer, thereby disrupting the morphogenesis of the epiblast [10].
  • In vitro, the ICM of the Mp(-/-) blastocysts failed to grow out appropriately [10].

Associations of Serpinb5 with chemical compounds

  • Maspin is structurally a member of the serpin (serine protease inhibitors) superfamily but deviates somewhat from classical serpins [2].
  • We show that treatment of Mp+/- mice with progesterone rescued the defect of ductal development [11].
  • By using a functional assay, we show that a serum component other than beta 2-microglobulin enhances the presentation of ovalbumin peptides produced by cyanogen bromide cleavage [12].
  • This earlier onset of S phase was not observed when Pronase treatment was performed in the presence of ovalbumin or the protease inhibitors phenylmethylsulfonyl fluoride or aprotinin [13].
  • LNCaP cells cultured in androgen-depleted medium show induction of Maspin promoter activity in a promoter luciferase reporter assay [7].

Regulatory relationships of Serpinb5


Other interactions of Serpinb5


Analytical, diagnostic and therapeutic context of Serpinb5


  1. Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins. Zhang, W., Shi, H.Y., Zhang, M. BMC Cancer (2005) [Pubmed]
  2. Tissue-type plasminogen activator is a target of the tumor suppressor gene maspin. Sheng, S., Truong, B., Fredrickson, D., Wu, R., Pardee, A.B., Sager, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis. Cher, M.L., Biliran, H.R., Bhagat, S., Meng, Y., Che, M., Lockett, J., Abrams, J., Fridman, R., Zachareas, M., Sheng, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Maspin is an angiogenesis inhibitor. Zhang, M., Volpert, O., Shi, Y.H., Bouck, N. Nat. Med. (2000) [Pubmed]
  5. Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. Narita, M., Bu, G., Herz, J., Schwartz, A.L. J. Clin. Invest. (1995) [Pubmed]
  6. Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells. Abraham, S., Zhang, W., Greenberg, N., Zhang, M. J. Urol. (2003) [Pubmed]
  7. Maspin expression profile in human prostate cancer (CaP) and in vitro induction of Maspin expression by androgen ablation. Zou, Z., Zhang, W., Young, D., Gleave, M.G., Rennie, P., Connell, T., Connelly, R., Moul, J., Srivastava, S., Sesterhenn, I. Clin. Cancer Res. (2002) [Pubmed]
  8. Selective increased presentation of type II collagen by leupeptin. Manoury-Schwartz, B., Chiocchia, G., Lotteau, V., Fournier, C. Int. Immunol. (1997) [Pubmed]
  9. Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: inhibition of allergen-specific T lymphocyte migration. Layton, G.T., Harris, S.J., Bland, F.A., Lee, S.R., Fearn, S., Kaleta, J., Wood, M.L., Bond, A., Ward, G. Inflamm. Res. (2001) [Pubmed]
  10. Maspin plays an essential role in early embryonic development. Gao, F., Shi, H.Y., Daughty, C., Cella, N., Zhang, M. Development (2004) [Pubmed]
  11. Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development. Shi, H.Y., Lydon, J.P., Zhang, M. Mol. Endocrinol. (2004) [Pubmed]
  12. Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules. Falo, L.D., Colarusso, L.J., Benacerraf, B., Rock, K.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. Pronase treatment of lymphocytes reduces the time required for onset of S phase in response to anti-immunoglobulin. Kern, M. J. Immunol. (1985) [Pubmed]
  14. Role of maspin in tumor metastasis and angiogenesis. Schaefer, J.S., Zhang, M. Curr. Mol. Med. (2003) [Pubmed]
  15. Maspin plays an important role in mammary gland development. Zhang, M., Magit, D., Botteri, F., Shi, H.Y., He, K., Li, M., Furth, P., Sager, R. Dev. Biol. (1999) [Pubmed]
  16. Maspin expression inversely correlates with breast tumor progression in MMTV/TGF-alpha transgenic mouse model. Reddy, K.B., McGowen, R., Schuger, L., Visscher, D., Sheng, S. Oncogene (2001) [Pubmed]
  17. Mast cells mediate substance P-induced bladder inflammation through an NK(1) receptor-independent mechanism. Saban, R., Gerard, N.P., Saban, M.R., Nguyen, N.B., DeBoer, D.J., Wershil, B.K. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  18. Maspin: synthesis by human cornea and regulation of in vitro stromal cell adhesion to extracellular matrix. Ngamkitidechakul, C., Burke, J.M., O'Brien, W.J., Twining, S.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  19. mMaspin: the mouse homolog of a human tumor suppressor gene inhibits mammary tumor invasion and motility. Zhang, M., Sheng, S., Maass, N., Sager, R. Mol. Med. (1997) [Pubmed]
  20. Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen. Mandl, S., Sigal, L.J., Rock, K.L., Andino, R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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