Disease relevance of arcA

• Regulation of arginine-ornithine exchange and the arginine deiminase pathway in Streptococcus lactis [1].
• Control of enzyme synthesis in the arginine deiminase pathway of Streptococcus faecalis [2].

High impact information on arcA

• Potential ArgR1/ArgR2 (double and single) binding sequences are found in the promoter regions of arcA and of argR1/argR2 themselves [3].
• Although Enteroccus faecalis is the paradigm for biochemical studies on the arginine deiminase (ADI) pathway of fermentative arginine catabolism, little genetic information exists on this pathway in this organism [3].
• We fill this important gap by characterizing, in an 8,228-bp region cloned from a lambdagt11 genomic library of E. faecalis, a five-gene cluster forming a transcriptional unit (revealed by Northern blots and primer extension in E. faecalis) that corresponds to the ADI operon [3].
• In the arginine deiminase pathway, uptake of arginine and excretion of ornithine are mediated by an arginine-ornithine antiport system [4].
• Conditions which lower ATP consumption (dicyclohexylcarbodiimide, high pH) decrease the ADI pathway activity, whereas uncouplers and ionophores which stimulate ATP consumption increase the activity [1].

Chemical compound and disease context of arcA

• Streptococcus lactis metabolizes arginine by the arginine deiminase (ADI) pathway [1].

Associations of arcA with chemical compounds

• Aeration had a weak repressing effect on the arginine deiminase pathway enzymes in cells growing on arginine as the only added substrate [2].
• The ADI operon genes, arcABCRD, encode, respectively, ADI, ornithine transcarbamylase, carbamate kinase, a putative Crp/Fnr-type regulator (ArcR), and a putative ornithine-arginine antiporter (ArcD) [3].
• Two carbamate kinases are present in S. faecalis, one belonging to the arginine deiminase pathway, the other being induced by growth on agmatine [5].
• The activity of the ADI pathway appears to be affected by the internal concentration of (adenine) nucleotides [1].
• Regulation of the ADI pathway and the arginine-ornithine exchanger at the level of enzyme synthesis is exerted by glucose (repressor, antagonized by cyclic AMP) and arginine (inducer) [1].

References