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Gene Review

xylM  -  xylM

Pseudomonas putida

 
 
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Disease relevance of xylM

  • Xylene monooxygenase, encoded by the TOL plasmid of Pseudomonas putida, catalyzes the oxidation of toluene and xylenes and consists of two different subunits encoded by xylA and xylM [1].
  • Recombinant Escherichia coli expressing the monooxygenase genes xylM and xylA catalyzes the oxygenation of toluene, pseudocumene, the corresponding alcohols, and the corresponding aldehydes, all by a monooxygenation type of reaction (B. Bühler, A. Schmid, B. Hauer, and B. Witholt, J. Biol. Chem. 275:10085-10092, 2000) [2].
 

High impact information on xylM

 

Chemical compound and disease context of xylM

 

Biological context of xylM

 

Associations of xylM with chemical compounds

 

Other interactions of xylM

  • Genetic studies have suggested that this monooxygenase consists of two different proteins, products of the xylA and xylM genes, which function as an electron-transfer protein and a terminal hydroxylase, respectively [6].
 

Analytical, diagnostic and therapeutic context of xylM

References

  1. Primary structure of xylene monooxygenase: similarities to and differences from the alkane hydroxylation system. Suzuki, M., Hayakawa, T., Shaw, J.P., Rekik, M., Harayama, S. J. Bacteriol. (1991) [Pubmed]
  2. Characterization and application of xylene monooxygenase for multistep biocatalysis. Bühler, B., Witholt, B., Hauer, B., Schmid, A. Appl. Environ. Microbiol. (2002) [Pubmed]
  3. Xylene monooxygenase catalyzes the multistep oxygenation of toluene and pseudocumene to corresponding alcohols, aldehydes, and acids in Escherichia coli JM101. Bühler, B., Schmid, A., Hauer, B., Witholt, B. J. Biol. Chem. (2000) [Pubmed]
  4. Suitability of recombinant Escherichia coli and Pseudomonas putida strains for selective biotransformation of m-nitrotoluene by xylene monooxygenase. Meyer, D., Witholt, B., Schmid, A. Appl. Environ. Microbiol. (2005) [Pubmed]
  5. Description of toluene inhibition of methyl bromide biodegradation in seawater and isolation of a marine toluene oxidizer that degrades methyl bromide. Goodwin, K.D., Tokarczyk, R., Stephens, F.C., Saltzman, E.S. Appl. Environ. Microbiol. (2005) [Pubmed]
  6. Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2. Shaw, J.P., Harayama, S. Eur. J. Biochem. (1992) [Pubmed]
  7. Extraction and purification of microbial DNA from petroleum-contaminated soils and detection of low numbers of toluene, octane and pesticide degraders by multiplex polymerase chain reaction and Southern analysis. Knaebel, D.B., Crawford, R.L. Mol. Ecol. (1995) [Pubmed]
 
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