The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cap1  -  CAP, adenylate cyclase-associated protein...

Mus musculus

Synonyms: Adenylyl cyclase-associated protein 1, CAP 1, Cap
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Cap1

  • Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells [1].
  • Analysis of CAP1 knockdown cells demonstrated that this protein promotes rapid actin filament depolymerization and is important for cell morphology, migration, and endocytosis [1].
  • Here, we show that CAP1 is widely expressed in mouse nonmuscle cells, whereas CAP2 is the predominant isoform in developing striated muscles [1].
  • In cultured NIH3T3 and B16F1 cells, CAP1 is a highly abundant protein that colocalizes with cofilin-1 to dynamic regions of the cortical actin cytoskeleton [1].
  • Finally, overexpression of Cap G in transfection assays increased the motility potential of endothelial cells [2].

Biological context of Cap1


Anatomical context of Cap1

  • We now report that a capsule-deficient (Cap-) mutant of LVS survives in the leukocytes [4].

Associations of Cap1 with chemical compounds

  • After opsonization in complement component C5-deficient nonimmune serum, the Cap- mutant was ingested and survived in the leukocytes [4].

Analytical, diagnostic and therapeutic context of Cap1

  • The genomic region immediately upstream of the cyclase associated protein homolog 1 (Cap1) gene was directly sequenced from PCR products [3].


  1. Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Bertling, E., Hotulainen, P., Mattila, P.K., Matilainen, T., Salminen, M., Lappalainen, P. Mol. Biol. Cell (2004) [Pubmed]
  2. Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress. Pellieux, C., Desgeorges, A., Pigeon, C.H., Chambaz, C., Yin, H., Hayoz, D., Silacci, P. J. Biol. Chem. (2003) [Pubmed]
  3. Cerebellar gene expression profiling and eQTL analysis in inbred mouse strains selected for ethanol sensitivity. MacLaren, E.J., Sikela, J.M. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  4. A capsule-deficient mutant of Francisella tularensis LVS exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes. Sandström, G., Löfgren, S., Tärnvik, A. Infect. Immun. (1988) [Pubmed]
WikiGenes - Universities