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Gene Review

SRV2  -  Srv2p

Saccharomyces cerevisiae S288c

Synonyms: Adenylyl cyclase-associated protein, CAP, CAP1, N1210, N1838, ...
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Disease relevance of SRV2

  • C. albicans strains with deletions of both alleles of CAP1 were avirulent in a mouse model of systemic candidiasis [1].

High impact information on SRV2

  • These results demonstrate that SRV2 protein is required for RAS-activated adenylate cyclase activity, but that it participates in other essential cellular functions as well [2].
  • We have identified a gene, SRV2, mutations of which alleviate stress sensitivity in strains carrying an activated RAS gene [2].
  • A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein [3].
  • Abp1p contains a single SH3 domain that has recently been shown to bind in vitro to the adenylyl cyclase-associated protein Srv2p [4].
  • In addition we have isolated a recessive negative allele of SRV2 that is defective for endocytosis [5].

Biological context of SRV2


Anatomical context of SRV2


Associations of SRV2 with chemical compounds


Physical interactions of SRV2


Other interactions of SRV2

  • Furthermore, this domain has an endocytic function that is redundant with the function(s) of ABP1 and SRV2 [5].
  • However, we found three classes of these proteins: WASP, Srv2/CAP and verprolin/WIP in yeast and animals [14].


  1. CAP1, an adenylate cyclase-associated protein gene, regulates bud-hypha transitions, filamentous growth, and cyclic AMP levels and is required for virulence of Candida albicans. Bahn, Y.S., Sundstrom, P. J. Bacteriol. (2001) [Pubmed]
  2. SRV2, a gene required for RAS activation of adenylate cyclase in yeast. Fedor-Chaiken, M., Deschenes, R.J., Broach, J.R. Cell (1990) [Pubmed]
  3. A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein. Mattila, P.K., Quintero-Monzon, O., Kugler, J., Moseley, J.B., Almo, S.C., Lappalainen, P., Goode, B.L. Mol. Biol. Cell (2004) [Pubmed]
  4. Evidence for physical and functional interactions among two Saccharomyces cerevisiae SH3 domain proteins, an adenylyl cyclase-associated protein and the actin cytoskeleton. Lila, T., Drubin, D.G. Mol. Biol. Cell (1997) [Pubmed]
  5. End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae. Wesp, A., Hicke, L., Palecek, J., Lombardi, R., Aust, T., Munn, A.L., Riezman, H. Mol. Biol. Cell (1997) [Pubmed]
  6. A cytoskeletal localizing domain in the cyclase-associated protein, CAP/Srv2p, regulates access to a distant SH3-binding site. Yu, J., Wang, C., Palmieri, S.J., Haarer, B.K., Field, J. J. Biol. Chem. (1999) [Pubmed]
  7. Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. Kawamukai, M., Gerst, J., Field, J., Riggs, M., Rodgers, L., Wigler, M., Young, D. Mol. Biol. Cell (1992) [Pubmed]
  8. Identification of a CAP (adenylyl-cyclase-associated protein) homologous gene in Lentinus edodes and its functional complementation of yeast CAP mutants. Zhou, G.L., Miyazaki, Y., Nakagawa, T., Tanaka, K., Shishido, K., Matsuda, H., Kawamukai, M. Microbiology (Reading, Engl.) (1998) [Pubmed]
  9. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Bahn, Y.S., Hicks, J.K., Giles, S.S., Cox, G.M., Heitman, J. Eukaryotic Cell (2004) [Pubmed]
  10. An actin-binding protein, CAP, is expressed in a subset of rat taste bud cells. Ishimaru, Y., Yasuoka, A., Asano-Miyoshi, M., Abe, K., Emori, Y. Neuroreport (2001) [Pubmed]
  11. Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae. Cvijic, M.E., Yang, W.L., Chin, K.V. Anticancer Res. (1998) [Pubmed]
  12. Association of elongation factor 1 alpha and ribosomal protein L3 with the proline-rich region of yeast adenylyl cyclase-associated protein CAP. Yanagihara, C., Shinkai, M., Kariya, K., Yamawaki-Kataoka, Y., Hu, C.D., Masuda, T., Kataoka, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  13. Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin. Gottwald, U., Brokamp, R., Karakesisoglou, I., Schleicher, M., Noegel, A.A. Mol. Biol. Cell (1996) [Pubmed]
  14. WH2 domain: a small, versatile adapter for actin monomers. Paunola, E., Mattila, P.K., Lappalainen, P. FEBS Lett. (2002) [Pubmed]
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