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Gene Review

Cap1  -  CAP, adenylate cyclase-associated protein...

Rattus norvegicus

Synonyms: Adenylyl cyclase-associated protein 1, CAP 1, Cap, Mch1
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High impact information on Cap1

  • The increased catecholamine and ACTH stimulation, and reduced GTP and adenosine sensitivities of adipocytes compared to preadipocytes suggest that a number of genes affecting adenylyl cyclase-associated regulatory and receptor proteins are coordinately repressed and derepressed during development [1].
  • 1 Capsaicin (Cap) enhanced the twitch response of the epididymal and prostatic portions of rat vas deferens induced by field stimulation at 0.1 Hz [2].
  • 4 Like Cap, substance K and substance P augmented the twitch response without causing desensitization, but their effects differed somewhat from that of Cap. Calcitonin gene-related peptide inhibited the twitch response [2].

Associations of Cap1 with chemical compounds

  • 5 These results suggest that Cap enhances a stimulation-induced, prazosin-resistant non-adrenergic twitch response of rat vas deferens through an as yet undefined prejunctional mechanism [2].

Analytical, diagnostic and therapeutic context of Cap1


  1. Hormone-sensitive adenylyl cyclase in preadipocytes cultured from adipose tissue: comparison with 3T3-L1 cells and adipocytes. Kirkland, J.L., Piñeyro, M.A., Lu, Z.D., Gregerman, R.I. J. Cell. Physiol. (1987) [Pubmed]
  2. Capsaicin enhances the non-adrenergic twitch response of rat vas deferens. Moritoki, H., Iwamoto, T., Kanaya, J., Ishida, Y., Ando, K., Kitagawa, K. Br. J. Pharmacol. (1987) [Pubmed]
  3. Molecular cloning and characterization of a rat homolog of CAP, the adenylyl cyclase-associated protein from Saccharomyces cerevisiae. Zelicof, A., Gatica, J., Gerst, J.E. J. Biol. Chem. (1993) [Pubmed]
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