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Gene Review

Cd2ap  -  CD2-associated protein

Mus musculus

Synonyms: AL024079, C78928, METS-1, Mesenchyme-to-epithelium transition protein with SH3 domains 1, Mets1
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Disease relevance of Cd2ap


High impact information on Cd2ap


Anatomical context of Cd2ap


Associations of Cd2ap with chemical compounds

  • Kidneys from Cd2ap -/- mice initially exhibited normal nephrin localization, but as the mice aged and foot processes became effaced, nephrin disappeared [1].


  1. CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. Li, C., Ruotsalainen, V., Tryggvason, K., Shaw, A.S., Miner, J.H. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  2. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Shih, N.Y., Li, J., Karpitskii, V., Nguyen, A., Dustin, M.L., Kanagawa, O., Miner, J.H., Shaw, A.S. Science (1999) [Pubmed]
  3. CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency. Grunkemeyer, J.A., Kwoh, C., Huber, T.B., Shaw, A.S. J. Biol. Chem. (2005) [Pubmed]
  4. CD2-associated protein directly interacts with the actin cytoskeleton. Lehtonen, S., Zhao, F., Lehtonen, E. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  5. Glomerular expression of transforming growth factor-beta (TGF-beta) isoforms in mice lacking CD2-associated protein. Woroniecki, R.P., Schiffer, M., Shaw, A.S., Kaskel, F.J., Bottinger, E.P. Pediatr. Nephrol. (2006) [Pubmed]
  6. Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. Jarad, G., Cunningham, J., Shaw, A.S., Miner, J.H. J. Clin. Invest. (2006) [Pubmed]
  7. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. Schiffer, M., Mundel, P., Shaw, A.S., Böttinger, E.P. J. Biol. Chem. (2004) [Pubmed]
  8. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. Lehtonen, S., Ora, A., Olkkonen, V.M., Geng, L., Zerial, M., Somlo, S., Lehtonen, E. J. Biol. Chem. (2000) [Pubmed]
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