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Gene Review

cheZ  -  protein phosphatase CheZ

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of cheZ


High impact information on cheZ


Chemical compound and disease context of cheZ


Associations of cheZ with chemical compounds

  • For strains with a severe parental mutation, such as the cheZ null mutations, adjustment of switch bias is essentially the only factor in suppression, since the attractant L-aspartate caused at most a slight further enhancement of the swarming rate over that occurring in the absence of a chemotactic stimulus [6].
  • Nalidixic acid at 200 microM, which inhibits the growth but not the motility of C. johnsonae, did not interfere with its negative chemotactic response to H2O2, whereas sodium phosphate at 10 mM, which inhibits motility, did so [10].


  1. Mutants with defective phosphatase activity show no phosphorylation-dependent oligomerization of CheZ. The phosphatase of bacterial chemotaxis. Blat, Y., Eisenbach, M. J. Biol. Chem. (1996) [Pubmed]
  2. Cysteine and disulfide scanning reveals a regulatory alpha-helix in the cytoplasmic domain of the aspartate receptor. Danielson, M.A., Bass, R.B., Falke, J.J. J. Biol. Chem. (1997) [Pubmed]
  3. Regulation of phosphatase activity in bacterial chemotaxis. Blat, Y., Gillespie, B., Bren, A., Dahlquist, F.W., Eisenbach, M. J. Mol. Biol. (1998) [Pubmed]
  4. An extreme clockwise switch bias mutation in fliG of Salmonella typhimurium and its suppression by slow-motile mutations in motA and motB. Togashi, F., Yamaguchi, S., Kihara, M., Aizawa, S.I., Macnab, R.M. J. Bacteriol. (1997) [Pubmed]
  5. Glycerol elicits energy taxis of Escherichia coli and Salmonella typhimurium. Zhulin, I.B., Rowsell, E.H., Johnson, M.S., Taylor, B.L. J. Bacteriol. (1997) [Pubmed]
  6. Molecular analysis of the flagellar switch protein FliM of Salmonella typhimurium. Sockett, H., Yamaguchi, S., Kihara, M., Irikura, V.M., Macnab, R.M. J. Bacteriol. (1992) [Pubmed]
  7. Purification and characterization of the CheZ protein of bacterial chemotaxis. Stock, A.M., Stock, J.B. J. Bacteriol. (1987) [Pubmed]
  8. Control of the receptor for galactose taxis in Salmonella typhimurium. Fahnestock, M., Koshland, D.E. J. Bacteriol. (1979) [Pubmed]
  9. Studies of bacterial chemotaxis in defined concentration gradients. A model for chemotaxis toward L-serine. Dahlquist, F.W., Elwell, R.A., Lovely, P.S. J. Supramol. Struct. (1976) [Pubmed]
  10. Negative chemotaxis in Cytophaga johnsonae. Liu, Z.X., Fridovich, I. Can. J. Microbiol. (1996) [Pubmed]
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