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Gene Review

Arhgap31  -  Rho GTPase activating protein 31

Mus musculus

Synonyms: 5830477L08Rik, AU041750, CdGAP, Cdc42 GTPase-activating protein, Cdgap, ...
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High impact information on Cdgap


Biological context of Cdgap

  • Also, the tissue distribution of CdGAP proteins appears to be different between human and mouse species [4].
  • CONCLUSIONS: Our results suggest that CdGAP properties are well conserved between human and mouse species, and that CdGAP may play an unexpected role in apoptosis [4].

Anatomical context of Cdgap


Associations of Cdgap with chemical compounds


Regulatory relationships of Cdgap


Other interactions of Cdgap

  • Here we show that through a subset of its Src homology 3 domains, the endocytic protein intersectin interacts with CdGAP [3].
  • We identify Thr776 as an in vivo target site of ERK1/2 and as an important regulatory site of CdGAP activity [2].
  • Furthermore, CdGAP interacts with and is phosphorylated by ERK-1 and RSK-1 in vitro [2].


  1. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Wang, L., Yang, L., Debidda, M., Witte, D., Zheng, Y. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  2. Extracellular signal-regulated kinase 1 interacts with and phosphorylates CdGAP at an important regulatory site. Tcherkezian, J., Danek, E.I., Jenna, S., Triki, I., Lamarche-Vane, N. Mol. Cell. Biol. (2005) [Pubmed]
  3. The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. Jenna, S., Hussain, N.K., Danek, E.I., Triki, I., Wasiak, S., McPherson, P.S., Lamarche-Vane, N. J. Biol. Chem. (2002) [Pubmed]
  4. The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA. Tcherkezian, J., Triki, I., Stenne, R., Danek, E.I., Lamarche-Vane, N. Biol. Cell (2006) [Pubmed]
  5. CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac. Lamarche-Vane, N., Hall, A. J. Biol. Chem. (1998) [Pubmed]
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