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Gene Review:

Dnase1l3 - deoxyribonuclease 1-like 3

Mus musculus

Synonyms: DNase I homolog protein DHP2, DNase I-like 3, DNase gamma, DNasegamma, Deoxyribonuclease I-like 3, ...

Shiokawa, D. et al., Wilber, A. et al., Valledor, A.F. et al.

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High impact information on Dnase1l3

Conversely, LXR and RXR agonists inhibited expression of proapoptotic regulators and effectors, including caspases 1, 4/11, 7, and 12; Fas ligand; and Dnase1l3 [1].
Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells [2].
The induction of DNase gamma occurs simultaneously with myogenin induction but precedes the up-regulation of p21 [2].
The role of DNase gamma in myoblast apoptosis was evaluated in the following experiments [2].
Our data demonstrate that DNase gamma is the endonuclease responsible for DNA fragmentation in apoptosis associated with myogenic differentiation [2].

Biological context of Dnase1l3

By in vitro expression studies, this substitution decreases this enzyme's nuclease activity against free DNA by only approximately twofold; however, the mutation has a greater effect on the capacity of media conditioned with Dnase1l3 to confer a barrier to liposomal gene transfection to HeLa cells [3].
DNA fragmentation during differentiation-induced apoptosis is strongly suppressed by the antisense-mediated down-regulation of DNase gamma [2].

Anatomical context of Dnase1l3

Finally, media conditioned by MRL and NZB/W F1 macrophages, relative to control, contains a weak interferon-gamma (IFN-gamma) inducible Dnase1l3-associated barrier to transfection [3].
A high level of DNase gamma expression was also detected in differentiated myotubes but not in skeletal muscle fibers in which DNase X is highly expressed [2].

References

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Valledor, A.F., Hsu, L.C., Ogawa, S., Sawka-Verhelle, D., Karin, M., Glass, C.K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Involvement of DNase gamma in apoptosis associated with myogenic differentiation of C2C12 cells. Shiokawa, D., Kobayashi, T., Tanuma, S. J. Biol. Chem. (2002) [Pubmed]
Dnase1l3 deficiency in lupus-prone MRL and NZB/W F1 mice. Wilber, A., O'Connor, T.P., Lu, M.L., Karimi, A., Schneider, M.C. Clin. Exp. Immunol. (2003) [Pubmed]

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DNASE1L3	Bos taurus
DNASE1L3	Canis lupus familiaris
dnase1l3l	Danio rerio
dnase1l3	Danio rerio
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