The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pnp  -  purine-nucleoside phosphorylase

Mus musculus

Synonyms: AL024301, AU015798, Inosine phosphorylase, Inosine-guanosine phosphorylase, Np, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pnp


High impact information on Pnp


Chemical compound and disease context of Pnp


Biological context of Pnp


Anatomical context of Pnp


Associations of Pnp with chemical compounds


Other interactions of Pnp


Analytical, diagnostic and therapeutic context of Pnp


  1. Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. Arpaia, E., Benveniste, P., Di Cristofano, A., Gu, Y., Dalal, I., Kelly, S., Hershfield, M., Pandolfi, P.P., Roifman, C.M., Cohen, A. J. Exp. Med. (2000) [Pubmed]
  2. Deoxyguanosine toxicity in a mouse T lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction. Gudas, L.J., Ullman, B., Cohen, A., Martin, D.W. Cell (1978) [Pubmed]
  3. Metabolism of purines in macrophages. Effect of functional state of the cells. Soberman, R.J., Karnovsky, M.L. J. Exp. Med. (1980) [Pubmed]
  4. Conversion of 6-thioguanine to the nucleoside level by purine nucleoside phosphorylase of sarcoma 180 and sarcoma 180/TG ascites cells. Lee, S.H., Sartorelli, A.C. Cancer Res. (1981) [Pubmed]
  5. Application of the ovarian teratoma mapping method in the mouse. Eppig, J.T., Eicher, E.M. Genetics (1983) [Pubmed]
  6. The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14. Dembić, Z., Bannwarth, W., Taylor, B.A., Steinmetz, M. Nature (1985) [Pubmed]
  7. Malathion A and B esterases of mouse liver--III: In vivo effect of parathion and related PNP-containing insecticides on esterase inhibition and potentiation of malathion toxicity. Ramakrishna, N., Ramachandran, B.V. Biochem. Pharmacol. (1978) [Pubmed]
  8. The effects of phenobarbital pretreatment on the metabolism and acute toxicity of the pesticide parathion in the mouse. Sultatos, L.G. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  9. Characterization of the metabolism of perinecrotic cells in solid tumors by enzyme histochemistry. Freitas, I., Bono, B., Bertone, V., Griffini, P., Baronzio, G.F., Bonandrini, L., Gerzeli, G. Anticancer Res. (1996) [Pubmed]
  10. Facilitated transport of inosine and uridine in cultured mammalian cells is independent of nucleoside phosphorylases. Plagemann, P.G., Wohlhueter, R.M., Erbe, J. Biochim. Biophys. Acta (1981) [Pubmed]
  11. Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14. Tzimagiorgis, G., Adamson, M.C., Kozak, C.A., Moschonas, N.K. Genomics (1991) [Pubmed]
  12. Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse. Snyder, F.F., Jenuth, J.P., Mably, E.R., Mangat, R.K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. Nucleotide sequence of murine purine nucleoside phosphorylase cDNA. Jenuth, J.P., Snyder, F.F. Nucleic Acids Res. (1991) [Pubmed]
  14. Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene. Grant, D.F., Spearow, J.L., Storms, D.H., Edelhoff, S., Adler, D.A., Disteche, C.M., Taylor, B.A., Hammock, B.D. Pharmacogenetics (1994) [Pubmed]
  15. Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message. Nelson, D.M., Foresman, M.D., Ronnei, B.J., McIvor, R.S. Gene (1992) [Pubmed]
  16. Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Lukey, T., Neote, K., Loman, J.F., Unger, A.E., Biddle, F.G., Snyder, F.F. Biochem. Genet. (1985) [Pubmed]
  17. Localization of the gene for interphotoreceptor retinoid-binding protein to mouse chromosome 14 near Np-1. Danciger, M., Kozak, C.A., Nickerson, J., Redmond, T.M., Farber, D.B. Genomics (1990) [Pubmed]
  18. Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14. Samuelson, L.C., Farber, R.A. Somat. Cell Mol. Genet. (1985) [Pubmed]
  19. Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants. Mably, E.R., Fung, E., Snyder, F.F. Genome (1989) [Pubmed]
  20. Active nuclear import of single-stranded oligonucleotides and their complexes with non-karyophilic macromolecules. Hartig, R., Shoeman, R.L., Janetzko, A., Grüb, S., Traub, P. Biol. Cell (1998) [Pubmed]
  21. Secondary loss of deoxyguanosine kinase activity in purine nucleoside phosphorylase deficient mice. Snyder, F.F., Jenuth, J.P., Dilay, J.E., Fung, E., Lightfoot, T., Mably, E.R. Biochim. Biophys. Acta (1994) [Pubmed]
  22. Assignment of pancreatic ribonuclease gene to mouse chromosome 14. Elliott, R.W., Samuelson, L.C., Lambert, M.S., Meisler, M.H. Cytogenet. Cell Genet. (1986) [Pubmed]
  23. Purine nucleoside metabolizing enzyme activities in mouse thymocytes at different stages of differentiation and maturation. Kizaki, H., Habu, S., Ohsaka, F., Sakurada, T. Cell. Immunol. (1983) [Pubmed]
  24. Provasopressin-neurophysin II processing is cell-specific in heterologous cell lines expressing a metallothionein-vasopressin fusion gene. Cwikel, B.J., Habener, J.F. J. Biol. Chem. (1987) [Pubmed]
  25. Purine nucleoside phosphorylase heterogeneity in the mouse as analyzed by isoelectric focusing and specific activity. Mably, E.R., Carter-Edwards, T., Biddle, F.G., Snyder, F.F. Comp. Biochem. Physiol., B (1988) [Pubmed]
WikiGenes - Universities