The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Adk  -  adenosine kinase

Mus musculus

Synonyms: 2310026J05Rik, 5033405D03Rik, AI255373, AI987814, AK, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Adk


High impact information on Adk

  • We have transferred the mouse Ak alpha and Ak beta genes, which encode the class II I-Ak molecule, into mouse L-cell fibroblasts and hamster B cells [7].
  • Cell lines expressing these genes were analyzed by quantitative immunofluorescence using 16 mAbs reactive to Ak beta or Ad beta [8].
  • Transfection of M12.C3 B lymphoma cells with most mutant Ak beta* genes results in the expression of Ak beta* Ad alpha molecules on the cell surface [9].
  • To identify which polymorphic residues determine the allospecific antibody binding sites on A beta polypeptides, mutant Ak beta genes were constructed encoding single or multiple amino acids of the d allele at 14 polymorphic positions in the beta 1 domain [8].
  • In this report we describe the DNA sequence analysis of the Ak beta gene of four cell lines that express serologically altered Ak beta polypeptides in association with wild-type Ak alpha polypeptides [10].

Chemical compound and disease context of Adk


Biological context of Adk


Anatomical context of Adk


Associations of Adk with chemical compounds


Regulatory relationships of Adk


Other interactions of Adk


Analytical, diagnostic and therapeutic context of Adk

  • Inclusion of the adenosine deaminase inhibitor coformycin (10 microM) and the adenosine kinase inhibitor 5'-iodotubercidin (0.1 microM) in the microdialysis perfusion buffer increased extracellular adenosine concentration in tumors to as high as 13 microM [26].
  • Since ontogeny of the adenosine system is largely unknown, we investigated ADK expression and cellular localization during postnatal development of the mouse brain, using immunofluorescence staining with cell-type specific markers [27].
  • The development of resistance to 3'-dANO was studied in cell cultures and found to be accompanied by changes in the enzyme activities of the reductase, the adenosine kinase, and the adenosine deaminase [28].
  • Sequence analysis of the Ak alpha gene showed that a single base transition (C----T) resulted in a stop codon at amino acid residue 222 [29].
  • To evaluate the potential functional role of the alpha- and beta-chain N-linked oligosaccharides we used site-directed mutagenesis to construct class II Ak alpha and Ak beta genes that encode polypeptides with altered N-linked oligosaccharide acceptor sites in the N-terminal domain of both polypeptides [30].


  1. Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides. Yeung, C.Y., Riser, M.E., Kellems, R.E., Siciliano, M.J. J. Biol. Chem. (1983) [Pubmed]
  2. Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart. Peart, J., Matherne, G.P., Cerniway, R.J., Headrick, J.P. Cardiovasc. Res. (2001) [Pubmed]
  3. Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines. Sastry, K.J., Huang, C., Chan, T.S. Biochem. Genet. (1987) [Pubmed]
  4. Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase. Green, R.D. Biochim. Biophys. Acta (1980) [Pubmed]
  5. Biochemical mode of cytotoxic action of neplanocin A in L1210 leukemic cells. Inaba, M., Nagashima, K., Tsukagoshi, S., Sakurai, Y. Cancer Res. (1986) [Pubmed]
  6. Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. Li, T., Ren, G., Lusardi, T., Wilz, A., Lan, J.Q., Iwasato, T., Itohara, S., Simon, R.P., Boison, D. J. Clin. Invest. (2008) [Pubmed]
  7. Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines. Malissen, B., Price, M.P., Goverman, J.M., McMillan, M., White, J., Kappler, J., Marrack, P., Pierres, A., Pierres, M., Hood, L. Cell (1984) [Pubmed]
  8. Identification of an immunodominant region on the I-A beta chain using site-directed mutagenesis and DNA-mediated gene transfer. Buerstedde, J.M., Pease, L.R., Bell, M.P., Nilson, A.E., Buerstedde, G., Murphy, D., McKean, D.J. J. Exp. Med. (1988) [Pubmed]
  9. Regulation of murine MHC class II molecule expression. Identification of A beta residues responsible for allele-specific cell surface expression. Buerstedde, J.M., Pease, L.R., Nilson, A.E., Bell, M.P., Chase, C., Buerstedde, G., McKean, D.J. J. Exp. Med. (1988) [Pubmed]
  10. DNA sequence analysis of I-Ak beta mutants reveals serologically immunodominant region. Beck, B.N., Pease, L.R., Bell, M.P., Buerstedde, J.M., Nilson, A.E., Schlauder, G.G., McKean, D.J. J. Exp. Med. (1987) [Pubmed]
  11. Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside. Epps, D., Chang, I.M., Sherwood, E., Kimball, A.P. Proc. Soc. Exp. Biol. Med. (1975) [Pubmed]
  12. Use of nucleoside kinase-deficient mouse leukemia L1210 cell lines to determine metabolic routes of activation of antitumor nucleoside analogs. Cory, A.H., Cory, J.G. Adv. Enzyme Regul. (1994) [Pubmed]
  13. Improved synthesis of 2'-deoxyformycin A and studies of its in vitro activity against mouse lymphoma of T-cell origin. Rosowsky, A., Solan, V.C., Gudas, L.J. J. Med. Chem. (1985) [Pubmed]
  14. Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14. Samuelson, L.C., Farber, R.A. Somat. Cell Mol. Genet. (1985) [Pubmed]
  15. Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Boison, D., Scheurer, L., Zumsteg, V., Rülicke, T., Litynski, P., Fowler, B., Brandner, S., Mohler, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  16. Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. Sahin, B., Kansy, J.W., Nairn, A.C., Spychala, J., Ealick, S.E., Fienberg, A.A., Greene, R.W., Bibb, J.A. Eur. J. Biochem. (2004) [Pubmed]
  17. Adenosine kinase as a new selective marker in somatic cell genetics: isolation of adenosine kinase--deficient mouse cell lines and human--mouse hybrid cell lines containing adenosine kinase. Chan, T.S., Creagan, R.P., Reardon, M.P. Somatic Cell Genet. (1978) [Pubmed]
  18. Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Leinwand, L., Fournier, R.E., Nichols, E.A., Ruddle, F.H. Cytogenet. Cell Genet. (1978) [Pubmed]
  19. Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. Gouder, N., Scheurer, L., Fritschy, J.M., Boison, D. J. Neurosci. (2004) [Pubmed]
  20. Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation. Van De Wiele, C.J., Vaughn, J.G., Blackburn, M.R., Ledent, C.A., Jacobson, M., Jiang, H., Thompson, L.F. J. Clin. Invest. (2002) [Pubmed]
  21. Purine nucleoside metabolizing enzyme activities in mouse thymocytes at different stages of differentiation and maturation. Kizaki, H., Habu, S., Ohsaka, F., Sakurada, T. Cell. Immunol. (1983) [Pubmed]
  22. Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy. Huber, A., Padrun, V., Déglon, N., Aebischer, P., Möhler, H., Boison, D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  23. Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells. Eves, E.M., Farber, R.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  24. Extracellular adenosine-induced apoptosis in mouse neuroblastoma cells: studies on involvement of adenosine receptors and adenosine uptake. Schrier, S.M., van Tilburg, E.W., van der Meulen, H., Ijzerman, A.P., Mulder, G.J., Nagelkerke, J.F. Biochem. Pharmacol. (2001) [Pubmed]
  25. Adenosine-dependent activation of tyrosine hydroxylase is defective in adenosine kinase-deficient PC12 cells. Erny, R., Wagner, J.A. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  26. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Blay, J., White, T.D., Hoskin, D.W. Cancer Res. (1997) [Pubmed]
  27. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Studer, F.E., Fedele, D.E., Marowsky, A., Schwerdel, C., Wernli, K., Vogt, K., Fritschy, J.M., Boison, D. Neuroscience (2006) [Pubmed]
  28. Synergistic effect of 3'-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo. Svendsen, K.R., Overgaard-Hansen, K., Frederiksen, S. Cancer Chemother. Pharmacol. (1988) [Pubmed]
  29. Cytoplasmic domain affects membrane expression and function of an Ia molecule. Griffith, I.J., Ghogawala, Z., Nabavi, N., Golan, D.E., Myer, A., McKean, D.J., Glimcher, L.H. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  30. Functional effects of N-linked oligosaccharides located on the external domain of murine class II molecules. Wei, B.Y., Buerstedde, J.M., Bell, M., Chase, C., Nilson, A., Browne, A., Pease, L., McKean, D.J. J. Immunol. (1991) [Pubmed]
WikiGenes - Universities