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Gene Review:

Wnt11 - wingless-type MMTV integration site family...

Rattus norvegicus

Katoh, Y. et al., Nguyen, H.T. et al., Ehrenfels, C.W. et al.

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High impact information on Wnt11

Treatment of embryonic kidney organ cultures with RET-Ig results in a decrease in branching of the ureteric bud and a down regulation in expression of the Wnt-11, Wnt-4, and ld genes [1].
Rat Wnt11 (354 aa) was a secreted protein with 24 conserved Cys residues and five Asn-linked glycosylation sites [2].
Rat Wnt11 gene, consisting of five exons, was identified within AC120107.3 genome sequence [2].

Biological context of Wnt11

During normal development, the amounts of mRNA encoding Wnt-4 and Wnt-11 increased during gestation and then abruptly decreased after the completion of metanephrogenesis, 15 days after birth [3].

References

Perturbation of RET signaling in the embryonic kidney. Ehrenfels, C.W., Carmillo, P.J., Orozco, O., Cate, R.L., Sanicola, M. Dev. Genet. (1999) [Pubmed]
Comparative genomics on Wnt11 gene. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
Expression of the Wnt gene family during late nephrogenesis and complete ureteral obstruction. Nguyen, H.T., Thomson, A.A., Kogan, B.A., Baskin, L.S., Cunha, G.R. Lab. Invest. (1999) [Pubmed]

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