The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

WNT11  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-11
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of WNT11


High impact information on WNT11


Biological context of WNT11


Anatomical context of WNT11

  • These have shown that the expression of human WNT11 is restricted to the perichondrium of the developing skeleton, lung mesenchyme, the tips of the ureteric buds and other areas of the urogenital system and the cortex of the adrenal gland [6].
  • The 4.3-kb WNT11 mRNA was expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas [1].
  • Xenopus Wnt11-R is expressed in neural tissue, dorsal mesenchyme derived from the dermatome region of the somites, the brachial arches, and the muscle layer of the heart, similar to the expression patterns reported for mouse and chicken Wnt11 [7].
  • We show that Wnt1 and Wnt3a signaling from the neural tube inhibit Wnt6 expression in the medial surface ectoderm via dermomyotomal Wnt11 [5].
  • Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes [8].

Associations of WNT11 with chemical compounds

  • Growth of hormone-dependent LNCaP cells in hormone-depleted media led to increased WNT11 expression, which was repressed by the synthetic androgen R1881 [2].
  • This repression was inhibited by the antiandrogen bicalutamide, suggesting that androgens negatively regulate WNT11 expression through the androgen receptor [2].

Regulatory relationships of WNT11


Other interactions of WNT11

  • However, expression of stabilized beta-catenin did not prevent the inhibition of androgen receptor transcriptional activity by WNT11 [2].
  • Facial cell soma migration defects were associated with the coordinate downregulation of multiple components of the planar cell polarity pathway including Fzd7, Wnt11, Prickle1, Vang1 and Vang2 [9].
  • Using truncated Frizzled and dominant-negative Wnt constructs, we then show the requirement of at least two Wnt proteins, Wnt8 and Wnt11, for Gli2/3-induced posterior mesodermal development [10].
  • We found that Wnt5b and Wnt11 are restricted within the prehypertrophic chondrocytes of the cartilage elements, Wnt5a is found in the joints and perichondrium, while Wnt4 is expressed in the developing joints and, in some bones, a subset of the hypertrophic chondrocytes [11].

Analytical, diagnostic and therapeutic context of WNT11

  • Molecular cloning and characterization of human WNT11 [1].
  • Additional analysis indicated that WNT11 expression is also elevated in high-grade prostatic tumors and in hormone-independent xenografts [2].
  • Supplementation of co-cultures with Wnt11-conditioned medium significantly enhanced the differentiation of CPCs to cardiomyocytes (1.7+/-0.3-fold), whereas Wnt3A-conditioned medium showed no effect [12].
  • Moreover, in situ hybridization reveals expression, although not temporal coincidence of, Wnt11 and Wnt7a in specialized tissues in the developing heart in vivo [13].


  1. Molecular cloning and characterization of human WNT11. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Mol. Med. (2001) [Pubmed]
  2. Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor. Zhu, H., Mazor, M., Kawano, Y., Walker, M.M., Leung, H.Y., Armstrong, K., Waxman, J., Kypta, R.M. Cancer Res. (2004) [Pubmed]
  3. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M., Heisenberg, C.P. J. Cell Biol. (2006) [Pubmed]
  4. Wnt11/{beta}-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Kofron, M., Birsoy, B., Houston, D., Tao, Q., Wylie, C., Heasman, J. Development (2007) [Pubmed]
  5. Regulation of ectodermal Wnt6 expression by the neural tube is transduced by dermomyotomal Wnt11: a mechanism of dermomyotomal lip sustainment. Geetha-Loganathan, P., Nimmagadda, S., Huang, R., Christ, B., Scaal, M. Development (2006) [Pubmed]
  6. Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Lako, M., Strachan, T., Bullen, P., Wilson, D.I., Robson, S.C., Lindsay, S. Gene (1998) [Pubmed]
  7. Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. Garriock, R.J., D'Agostino, S.L., Pilcher, K.C., Krieg, P.A. Dev. Biol. (2005) [Pubmed]
  8. Opposing roles of WNT-5A and WNT-11 in interleukin-1beta regulation of type II collagen expression in articular chondrocytes. Ryu, J.H., Chun, J.S. J. Biol. Chem. (2006) [Pubmed]
  9. T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Song, M.R., Shirasaki, R., Cai, C.L., Ruiz, E.C., Evans, S.M., Lee, S.K., Pfaff, S.L. Development (2006) [Pubmed]
  10. Wnt signals are targets and mediators of Gli function. Mullor, J.L., Dahmane, N., Sun, T., Ruiz i Altaba, A. Curr. Biol. (2001) [Pubmed]
  11. Wnt regulation of chondrocyte differentiation. Church, V., Nohno, T., Linker, C., Marcelle, C., Francis-West, P. J. Cell. Sci. (2002) [Pubmed]
  12. Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. Koyanagi, M., Haendeler, J., Badorff, C., Brandes, R.P., Hoffmann, J., Pandur, P., Zeiher, A.M., Kühl, M., Dimmeler, S. J. Biol. Chem. (2005) [Pubmed]
  13. Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo. Bond, J., Sedmera, D., Jourdan, J., Zhang, Y., Eisenberg, C.A., Eisenberg, L.M., Gourdie, R.G. Dev. Dyn. (2003) [Pubmed]
WikiGenes - Universities