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Gene Review

Wnt11  -  wingless-type MMTV integration site family...

Mus musculus

Synonyms: Protein Wnt-11, Wnt-11
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High impact information on Wnt11

  • Treating the mouse embryonic carcinoma stem cell line P19 with murine Wnt-11 conditioned medium triggers cardiogenesis, which indicates that the function of Wnt-11 in heart development has been conserved in higher vertebrates [1].
  • By contrast, when S-GAGs synthesis is not inhibited, BMP4 beads inhibit ureter branching and expression of Wnt 11, a target of glial cell-derived neurotrophic factor signaling [2].
  • Studies of Wnt11 and Fras1/Grip1, all expressed in the ureteric bud, show a role for these genes in regulating events in the adjacent metanephric mesenchyme [3].
  • The experimentally induced dysmorphology associated with deregulated expression of Wnt11, Gdnf and Fgf7 genes in the early stages of organogenesis indicated a crucial role for sprouty function in coordination of epithelial-mesenchymal and stromal signalling, the sites of expression of these genes [4].
  • Wnt11 functions, in part, by maintaining normal expression levels of the gene encoding glial cell-derived neurotrophic factor (Gdnf) [5].

Biological context of Wnt11

  • Mutation of the Wnt11 gene results in ureteric branching morphogenesis defects and consequent kidney hypoplasia in newborn mice [5].
  • Wnt11, a member of the Wnt superfamily of secreted glycoproteins, which have important regulatory functions during vertebrate embryonic development, is specifically expressed in the tips of the branching ureteric epithelium [5].
  • Upregulation of Wnt11 is temporally coordinated with the surge of maternal estradiol on Day 4 [6].
  • Based on these results, we propose that Wnt11 plays an important role for cardiac development by embryoid bodies, and may be a key regulator of cardiac muscle cell proliferation and differentiation during heart development [7].
  • A phylogenetic analysis of all known full-length Wnt11 sequences indicates that a gene duplication occurred at the base of the vertebrate Wnt11 clade [8].

Anatomical context of Wnt11


Associations of Wnt11 with chemical compounds

  • Moreover, in both cell types, elevation of intracellular Ca(2+) levels, which can result from Wnt11 treatment, led to the inhibition of canonical signaling [9].
  • Administration of estradiol-17beta or its metabolite, 4-OH-estradiol, to ovariectomized mice restores Wnt11 expression [6].
  • First, we examined the expression profile of Wnt11 during the course of differentiation in embryoid bodies, and then compared its expression in retinoic acid-treated embryoid bodies with that in untreated [7].
  • Here we demonstrate that Wnt-4, a secreted glycoprotein which is required for tubule formation, is sufficient to trigger tubulogenesis in isolated metanephric mesenchyme, whereas Wnt-11 which is expressed in the tip of the growing ureter is not [12].
  • The Wnt-11 gene encodes Cys-rich secretory protein distantly related to Wnt-1 through Wnt-8 from the mouse and Xenopus [13].

Other interactions of Wnt11

  • Co-culture experiments with NIH3T3 cells showed that the co-expression of Wnt11 with Wnt1 was not an essential requirement for the inhibition, suggesting receptor competition as a possible mechanism [9].
  • 5. Wnt11 is highly expressed at the gastro-esophageal junctions, while Wnt4 is found in the epithelium lining the pyloric region of the stomach but not in the epithelium of the prospective gland region [10].
  • Wnt7a was mapped to mouse Chr 6, Wnt5a to the centromeric region of Chr 14, and Wnt11 to Chr7 [14].
  • Other members expressed are Wnt2b, Wnt5b, and Wnt11 [15].
  • However, Wnt11 was unable to inhibit canonical signaling activated by LRP5, Dvl1, or beta-catenin in NIH3T3 cells, although it could in P19 cells [9].

Analytical, diagnostic and therapeutic context of Wnt11


  1. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Pandur, P., Läsche, M., Eisenberg, L.M., Kühl, M. Nature (2002) [Pubmed]
  2. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. Miyazaki, Y., Oshima, K., Fogo, A., Hogan, B.L., Ichikawa, I. J. Clin. Invest. (2000) [Pubmed]
  3. Recent genetic studies of mouse kidney development. Yu, J., McMahon, A.P., Valerius, M.T. Curr. Opin. Genet. Dev. (2004) [Pubmed]
  4. Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Chi, L., Zhang, S., Lin, Y., Prunskaite-Hyyryläinen, R., Vuolteenaho, R., Itäranta, P., Vainio, S. Development (2004) [Pubmed]
  5. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Majumdar, A., Vainio, S., Kispert, A., McMahon, J., McMahon, A.P. Development (2003) [Pubmed]
  6. Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation. Mohamed, O.A., Dufort, D., Clarke, H.J. Biol. Reprod. (2004) [Pubmed]
  7. Wnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes. Terami, H., Hidaka, K., Katsumata, T., Iio, A., Morisaki, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  8. Characterization of an amphioxus wnt gene, AmphiWnt11, with possible roles in myogenesis and tail outgrowth. Schubert, M., Holland, L.Z., Holland, N.D. Genesis (2000) [Pubmed]
  9. Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. Maye, P., Zheng, J., Li, L., Wu, D. J. Biol. Chem. (2004) [Pubmed]
  10. Expression patterns of Wnt genes in mouse gut development. Lickert, H., Kispert, A., Kutsch, S., Kemler, R. Mech. Dev. (2001) [Pubmed]
  11. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Kispert, A., Vainio, S., Shen, L., Rowitch, D.H., McMahon, A.P. Development (1996) [Pubmed]
  12. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Kispert, A., Vainio, S., McMahon, A.P. Development (1998) [Pubmed]
  13. A chicken Wnt gene, Wnt-11, is involved in dermal development. Tanda, N., Ohuchi, H., Yoshioka, H., Noji, S., Nohno, T. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  14. Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Adamson, M.C., Dennis, C., Delaney, S., Christiansen, J., Monkley, S., Kozak, C.A., Wainwright, B. Genomics (1994) [Pubmed]
  15. Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation. Heller, R.S., Dichmann, D.S., Jensen, J., Miller, C., Wong, G., Madsen, O.D., Serup, P. Dev. Dyn. (2002) [Pubmed]
  16. Cloning and characterization of Wnt-4 and Wnt-11 cDNAs from chick embryo. Tanda, N., Kawakami, Y., Saito, T., Noji, S., Nohno, T. DNA Seq. (1995) [Pubmed]
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