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Gene Review

FZD8  -  frizzled class receptor 8

Homo sapiens

Synonyms: FZ-8, Frizzled-8, Fz-8, hFZ8, hFz8
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Disease relevance of FZD8


High impact information on FZD8

  • GOPC interacts with many other proteins, such as the Wnt receptors Frizzled 8 and neuroligin via its PDZ domain [4].
  • Among 10 cases of primary gastric cancer, FZD9 was up-regulated in 2 cases, FZD2 and FZD8 were up-regulated in 4 cases [1].
  • Among human FZD family, FZD8 was most homologous to FZD5 (total amino-acid identity 69.1%) [2].
  • FZD8 was found to encode a 694 amino-acid polypeptide with the frizzled-like cysteine-rich domain, seven transmembrane domains, and the C-terminal Ser/Thr-X-Val motif [2].
  • Up-regulation of FZD8 might play key roles in several types of human cancer through activation of the beta-catenin-TCF pathway [2].

Chemical compound and disease context of FZD8


Biological context of FZD8


Other interactions of FZD8

  • However, wnt inhibitors Dkk-1 or Frizzled-8/Fc chimeric protein augmented, but wnt3a inhibited, cardiomyocyte differentiation [6].

Analytical, diagnostic and therapeutic context of FZD8


  1. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  2. Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2. Saitoh, T., Hirai, M., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  3. An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Keay, S.K., Szekely, Z., Conrads, T.P., Veenstra, T.D., Barchi, J.J., Zhang, C.O., Koch, K.R., Michejda, C.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin. Li, X., Zhang, J., Cao, Z., Wu, J., Shi, Y. Protein Sci. (2006) [Pubmed]
  5. CKAP4/p63 Is a Receptor for the Frizzled-8 Protein-related Antiproliferative Factor from Interstitial Cystitis Patients. Conrads, T.P., Tocci, G.M., Hood, B.L., Zhang, C.O., Guo, L., Koch, K.R., Michejda, C.J., Veenstra, T.D., Keay, S.K. J. Biol. Chem. (2006) [Pubmed]
  6. Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction. Yamashita, J.K., Takano, M., Hiraoka-Kanie, M., Shimazu, C., Peishi, Y., Yanagi, K., Nakano, A., Inoue, E., Kita, F., Nishikawa, S. FASEB J. (2005) [Pubmed]
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