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Gene Review

Hoxa7  -  homeobox A7

Mus musculus

Synonyms: AV118143, Homeobox protein Hox-1.1, Homeobox protein Hox-A7, Homeobox protein M6-12, Hox-1.1, ...
 
 
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Disease relevance of Hoxa7

 

High impact information on Hoxa7

 

Biological context of Hoxa7

  • Mice homozygous for both mutations have first and second rib defects with higher penetrance and increased expressivity, indicating a functional role for Hoxa7 in the patterning of the upper thoracic region [8].
  • However, Hoxa7(-/-) or Hoxa9(-/-) progenitors were less efficient in generating transformed blast colony-forming units (CFUs) in vitro and induced leukemias with longer disease latencies, reduced penetrance, and less mature phenotypes [2].
  • Additionally, the expression domains of two Hox genes, Hoxa7 and Hoxa10, were examined in gestation day (GD) 12.5 embryos obtained from control, RA, VA, or Br, treated gravid dams exposed on GD 6, 7, or 8 [9].
  • The murine homeobox Hox 1.1 (m6) is the first of a cluster of six boxes on chromosome 6 [10].
  • The presence of this protein in F9 cell nuclei is in faithful accordance with the kinetics established for the 2.4-kilobase Hox 1.1 transcript during differentiation into parietal endoderm cells [10].
 

Anatomical context of Hoxa7

  • Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae [8].
  • Selective reductions in the absolute numbers of committed progenitors, but not of hematopoietic stem cells, distinguished Hoxa7- and Hoxa9-deficient mice [2].
  • 5. We demonstrate that the competence of neural tissue to express the posterior markers Hoxa7 and Xcad3, in response to FGF signalling, is lost by the end of gastrula stages [11].
  • We also show that chick Hoxa-7 and a-10 expression domains spread forward into regions of somites that are initially negative for the expression of these genes [12].
  • Specifically, we show how the expression domains of Hoxa-7, a-9 and a-10 in spinal ganglia correspond similarly in both mouse and chick with the positions of the brachial and lumbosacral plexuses, and that this is true even though the brachial plexus of chick is shifted posteriorly, relative to mouse, by seven segmental units [12].
 

Associations of Hoxa7 with chemical compounds

 

Other interactions of Hoxa7

 

Analytical, diagnostic and therapeutic context of Hoxa7

  • Additionally, Hoxa7 transcript quantified by real-time PCR strongly correlated (r2=0.89) with the number of Hoxa7 clones identified by sequencing, validating that data from the PCR screen reflects differences in Hox mRNA abundance between populations [18].
  • Northern blot analysis indicated the transcript size of Hoxa-7 to be 2.1-2.4 kb [19].
  • By means of indirect immunofluorescence we localized the Hox 1.1 protein to the nucleus in differentiated F9 and NIH 3T3 cells [20].

References

  1. Identification of a new family of Pbx-related homeobox genes. Nakamura, T., Jenkins, N.A., Copeland, N.G. Oncogene (1996) [Pubmed]
  2. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. So, C.W., Karsunky, H., Wong, P., Weissman, I.L., Cleary, M.L. Blood (2004) [Pubmed]
  3. Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. Balling, R., Mutter, G., Gruss, P., Kessel, M. Cell (1989) [Pubmed]
  4. Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. Cannizzaro, L.A., Croce, C.M., Griffin, C.A., Simeone, A., Boncinelli, E., Huebner, K. Am. J. Hum. Genet. (1987) [Pubmed]
  5. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Subramanian, V., Meyer, B.I., Gruss, P. Cell (1995) [Pubmed]
  6. Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Kessel, M., Balling, R., Gruss, P. Cell (1990) [Pubmed]
  7. Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Zimmer, A., Gruss, P. Nature (1989) [Pubmed]
  8. Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Chen, F., Greer, J., Capecchi, M.R. Mech. Dev. (1998) [Pubmed]
  9. Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development. Kawanishi, C.Y., Hartig, P., Bobseine, K.L., Schmid, J., Cardon, M., Massenburg, G., Chernoff, N. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  10. Primary structure and nuclear localization of a murine homeodomain protein. Kessel, M., Schulze, F., Fibi, M., Gruss, P. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. An inducible system for the study of FGF signalling in early amphibian development. Pownall, M.E., Welm, B.E., Freeman, K.W., Spencer, D.M., Rosen, J.M., Isaacs, H.V. Dev. Biol. (2003) [Pubmed]
  12. Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm. Gaunt, S.J., Dean, W., Sang, H., Burton, R.D. Mech. Dev. (1999) [Pubmed]
  13. Intron of the mouse Hoxa-7 gene contains conserved homeodomain binding sites that can function as an enhancer element in Drosophila. Haerry, T.E., Gehring, W.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  14. Selection of ten base-pair sequences which enhance the response of the Gal1 minimal promoter to murine Hoxa-7 in yeast. Gross, M.K., Gruss, P. J. Mol. Biol. (1995) [Pubmed]
  15. Post-transcriptional regulation of a murine homeobox gene transcript in F9 embryonal carcinoma cells. Colberg-Poley, A.M., Püschel, A.W., Dony, C., Voss, S.D., Gruss, P. Differentiation (1987) [Pubmed]
  16. Coding sequence and expression of the homeobox gene Hox 1.3. Fibi, M., Zink, B., Kessel, M., Colberg-Poley, A.M., Labeit, S., Lehrach, H., Gruss, P. Development (1988) [Pubmed]
  17. Heat shock-induced homeotic transformations of the axial skeleton and associated shifts of Hox gene expression domains in mouse embryos. Li, Z.L., Chisaka, O., Koseki, H., Akasaka, T., Ishibashi, M., Shiota, K. Reprod. Toxicol. (1997) [Pubmed]
  18. Murine mesenchymal and embryonic stem cells express a similar Hox gene profile. Phinney, D.G., Gray, A.J., Hill, K., Pandey, A. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  19. Organization, sequence and regulation of expression of the murine Hoxa-7 gene. Parikh, H., Shah, S., Hilt, D., Peterkofsky, A. Gene (1995) [Pubmed]
  20. The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin. Schulze, F., Chowdhury, K., Zimmer, A., Drescher, U., Gruss, P. Differentiation (1987) [Pubmed]
 
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