Gene Review:
Hoxa9 - homeobox A9
Mus musculus
Synonyms:
D6a9, Homeobox protein Hox-1.7, Homeobox protein Hox-A9, Hox-1.7, Hoxa-9
- Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation. Mamo, A., Krosl, J., Kroon, E., Bijl, J., Thompson, A., Mayotte, N., Girard, S., Bisaillon, R., Beslu, N., Featherstone, M., Sauvageau, G. Blood (2006)
- Identification of a new family of Pbx-related homeobox genes. Nakamura, T., Jenkins, N.A., Copeland, N.G. Oncogene (1996)
- Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. So, C.W., Karsunky, H., Wong, P., Weissman, I.L., Cleary, M.L. Blood (2004)
- Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression. Rubin, M.R., King, W., Toth, L.E., Sawczuk, I.S., Levine, M.S., D'Eustachio, P., Nguyen-Huu, M.C. Mol. Cell. Biol. (1987)
- Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells. Lawrence, H.J., Christensen, J., Fong, S., Hu, Y.L., Weissman, I., Sauvageau, G., Humphries, R.K., Largman, C. Blood (2005)
- The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Chen, Y.X., Yan, J., Keeshan, K., Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S., Hua, X. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Chen, F., Capecchi, M.R. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia. Kumar, A.R., Hudson, W.A., Chen, W., Nishiuchi, R., Yao, Q., Kersey, J.H. Blood (2004)
- Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression. Calvo, K.R., Sykes, D.B., Pasillas, M., Kamps, M.P. Mol. Cell. Biol. (2000)
- Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Thorsteinsdottir, U., Mamo, A., Kroon, E., Jerome, L., Bijl, J., Lawrence, H.J., Humphries, K., Sauvageau, G. Blood (2002)
- Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. Fujino, T., Yamazaki, Y., Largaespada, D.A., Jenkins, N.A., Copeland, N.G., Hirokawa, K., Nakamura, T. Exp. Hematol. (2001)
- Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in müllerian duct by the synthetic estrogen diethylstilbestrol (DES). Ma, L., Benson, G.V., Lim, H., Dey, S.K., Maas, R.L. Dev. Biol. (1998)
- The developmental expression pattern of a new murine homeo box gene: Hox-2.5. Bogarad, L.D., Utset, M.F., Awgulewitsch, A., Miki, T., Hart, C.P., Ruddle, F.H. Dev. Biol. (1989)
- c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Hess, J.L., Bittner, C.B., Zeisig, D.T., Bach, C., Fuchs, U., Borkhardt, A., Frampton, J., Slany, R.K. Blood (2006)
- Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Doll e, P., Chambon, P. Development (1996)
- Analysis of the murine Hoxa-9 cDNA: an alternatively spliced transcript encodes a truncated protein lacking the homeodomain. Fujimoto, S., Araki, K., Chisaka, O., Araki, M., Takagi, K., Yamamura, K. Gene (1998)