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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC25A10  -  solute carrier family 25 (mitochondrial...

Homo sapiens

Synonyms: DIC, Mitochondrial dicarboxylate carrier, Solute carrier family 25 member 10
 
 
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High impact information on SLC25A10

  • As expected from the role of the DIC in gluconeogenesis and ureogenesis, its transcripts were detected in rat liver and kidney, but unexpectedly, they were also detected in rat heart and brain tissues where the protein may fulfill other roles, possibly in supplying substrates to the Krebs cycle [1].
  • Both proteins were expressed in bacteria and reconstituted into phospholipid vesicles where their transport characteristics closely resembled those of whole rat mitochondria and of the rat DIC reconstituted into vesicles [1].
  • We have used the sequence of the distantly related yeast DIC to identify a related protein encoded in the genome of Caenorhabditis elegans [1].
  • The dicarboxylate carrier (DIC) is a nuclear-encoded protein located in the mitochondrial inner membrane [2].
  • Overexpression of the cDNA for the DIC and OGC in a renal proximal tubule-derived cell line, NRK-52E cells, showed that enhanced carrier expression and activity protects against oxidative stress and chemically induced apoptosis [3].
 

Biological context of SLC25A10

 

Analytical, diagnostic and therapeutic context of SLC25A10

  • It has been demonstrated by Northern- and Western-blot analyses that the DIC is present in high amounts in liver and kidney, and at lower levels in all the other tissues analysed [2].

References

  1. The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans. Fiermonte, G., Palmieri, L., Dolce, V., Lasorsa, F.M., Palmieri, F., Runswick, M.J., Walker, J.E. J. Biol. Chem. (1998) [Pubmed]
  2. Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family. Fiermonte, G., Dolce, V., Arrigoni, R., Runswick, M.J., Walker, J.E., Palmieri, F. Biochem. J. (1999) [Pubmed]
  3. Mitochondrial glutathione transport: Physiological, pathological and toxicological implications. Lash, L.H. Chem. Biol. Interact. (2006) [Pubmed]
  4. Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3. Pannone, E., Fiermonte, G., Dolce, V., Rocchi, M., Palmieri, F. Cytogenet. Cell Genet. (1998) [Pubmed]
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