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Gene Review

UL10  -  type 3 membrane protein; 8 transmembrane...

Bovine herpesvirus 1

 
 
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Disease relevance of UL10

 

High impact information on UL10

  • However, in BHV-1-infected cells, differences in UL49.5 and gM expression kinetics were seen to create a window of opportunity at the early stages of infection, during which time the UL49.5 protein can act on TAP without gM interference [2].
  • In cell lines constitutively expressing both UL49.5 and gM, UL49.5 appears to be required for functional processing of gM [2].
  • Alphaherpesvirus glycoprotein M causes the relocalization of plasma membrane proteins [3].
  • Here, the effect of pseudorabies virus (PRV) gM and the herpes simplex virus type 1 (HSV-1) gM/UL49A complex on the fusion events caused by the HSV-1 glycoproteins gB, gD, gH and gL was investigated [3].
  • Infection of cell cultures with the resulting gM(-) mutant of BHV-1/F(syn) led to formation of syncytia, whereas the CPE in gM(-)BHV-1 infected cells was comparable to the CPE in wtBHV-1 infected cultures [4].
 

Biological context of UL10

  • Our results demonstrate that gM is not essential for BHV-1 replication in cell culture and that gM is involved in inhibition of the cell fusion activity of the BHV-1 expressed BRSV F protein [4].

References

 
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