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Gene Review

IL23R  -  interleukin 23 receptor

Homo sapiens

Synonyms: IL-23 receptor, IL-23R, Interleukin-23 receptor


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Disease relevance of IL23R

  • An uncommon coding variant (rs11209026, c.1142G>A, p.Arg381Gln) confers strong protection against Crohn's disease, and additional noncoding IL23R variants are independently associated [1].
  • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene [1].
  • METHODS: We describe the first patient, to our knowledge, with PCM and a well-defined primary immunodeficiency in the beta 1 subunit of the interleukin (IL)-12/IL-23 receptor, a disorder previously shown to be specifically associated with impaired interferon (IFN)-gamma production, mycobacteriosis, and salmonellosis [2].
  • Therefore, targeting of IL-23 or the IL-23 receptor is a promising therapeutic approach for autoimmune diseases [3].
  • No association was found between IL23R or ATG16L1 and celiac disease [4].
  • This concurrent analysis of 3 distinct AS populations and their regional controls demonstrates a disease association with the IL-23R locus and implicates the same polymorphisms associated with IBD and psoriasis [5].

High impact information on IL23R

  • Individuals homozygous for both the IL12B and the IL23R predisposing haplotypes have an increased risk of disease (OR(common) 1.66, Pcomb=1.33x10-8) [6].
  • Patients with mutations in IL12RB1, the gene encoding IL-12Rbeta1, suffer from combined IL-12R/IL-23R deficiency and are unusually susceptible to nontuberculous mycobacteria and salmonellae [7].
  • Moreover, T-bet was found to directly regulate transcription of the IL-23R, and, in doing so, influenced the fate of Th17 cells, which depend on optimal IL-23 production for survival [8].
  • Anti-IL-12Rbeta1 and anti-IL-23R Abs block IL-23 responses of an NK cell line and Ba/F3 cells expressing the two receptor chains [9].
  • The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12Rbeta2 [9].

Biological context of IL23R

  • Here, we demonstrate that at least six spliced isoforms of IL-23R (IL-23R1 to 6) can be generated through alternative splicing [10].
  • The standard form of IL-23R is encoded by at least 12 exons [10].
  • Haplotype analyses identified two IL23R missense SNPs that together mark a common psoriasis-associated haplotype in all three studies (OR(common) 1.44, Pcomb=3.13x10-6) [6].
  • We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23 [1].

Anatomical context of IL23R

  • Differential expressions of IL-23R spliced variants are observed in natural killer and CD3+ CD4+ T cells [10].
  • Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells [10].
  • We now show for the first time that suppression of T-bet ameliorates EAE by limiting the differentiation of autoreactive Th1 cells, as well as inhibiting pathogenic Th17 cells via regulation of IL-23R [8].

Other interactions of IL23R

  • The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12Rbeta2, respectively [9].
  • IL23R was associated with CD and UC only in the absence of CARD15 mutations, whereas ATG16L1 was associated with CD in the presence and absence of CARD15 mutations [11].


  1. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Duerr, R.H., Taylor, K.D., Brant, S.R., Rioux, J.D., Silverberg, M.S., Daly, M.J., Steinhart, A.H., Abraham, C., Regueiro, M., Griffiths, A., Dassopoulos, T., Bitton, A., Yang, H., Targan, S., Datta, L.W., Kistner, E.O., Schumm, L.P., Lee, A.T., Gregersen, P.K., Barmada, M.M., Rotter, J.I., Nicolae, D.L., Cho, J.H. Science (2006) [Pubmed]
  2. Paracoccidioides brasiliensis disseminated disease in a patient with inherited deficiency in the beta1 subunit of the interleukin (IL)-12/IL-23 receptor. Moraes-Vasconcelos, D., Grumach, A.S., Yamaguti, A., Andrade, M.E., Fieschi, C., Beaucoudrey, L., Casanova, J.L., Duarte, A.J. Clin. Infect. Dis. (2005) [Pubmed]
  3. Targeting IL-23 in autoimmunity. Hölscher, C. Current opinion in investigational drugs (London, England : 2000) (2005) [Pubmed]
  4. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands. Weersma, R.K., Zhernakova, A., Nolte, I.M., Lefebvre, C., Rioux, J.D., Mulder, F., van Dullemen, H.M., Kleibeuker, J.H., Wijmenga, C., Dijkstra, G. Am. J. Gastroenterol. (2008) [Pubmed]
  5. Association of interleukin-23 receptor variants with ankylosing spondylitis. Rahman, P., Inman, R.D., Gladman, D.D., Reeve, J.P., Peddle, L., Maksymowych, W.P. Arthritis Rheum. (2008) [Pubmed]
  6. A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes. Cargill, M., Schrodi, S.J., Chang, M., Garcia, V.E., Brandon, R., Callis, K.P., Matsunami, N., Ardlie, K.G., Civello, D., Catanese, J.J., Leong, D.U., Panko, J.M., McAllister, L.B., Hansen, C.B., Papenfuss, J., Prescott, S.M., White, T.J., Leppert, M.F., Krueger, G.G., Begovich, A.B. Am. J. Hum. Genet. (2007) [Pubmed]
  7. Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency. van de Vosse, E., de Paus, R.A., van Dissel, J.T., Ottenhoff, T.H. Hum. Mol. Genet. (2005) [Pubmed]
  8. T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity. Gocke, A.R., Cravens, P.D., Ben, L.H., Hussain, R.Z., Northrop, S.C., Racke, M.K., Lovett-Racke, A.E. J. Immunol. (2007) [Pubmed]
  9. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. Parham, C., Chirica, M., Timans, J., Vaisberg, E., Travis, M., Cheung, J., Pflanz, S., Zhang, R., Singh, K.P., Vega, F., To, W., Wagner, J., O'Farrell, A.M., McClanahan, T., Zurawski, S., Hannum, C., Gorman, D., Rennick, D.M., Kastelein, R.A., de Waal Malefyt, R., Moore, K.W. J. Immunol. (2002) [Pubmed]
  10. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. Zhang, X.Y., Zhang, H.J., Zhang, Y., Fu, Y.J., He, J., Zhu, L.P., Wang, S.H., Liu, L. Immunogenetics (2006) [Pubmed]
  11. IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease. Roberts, R.L., Gearry, R.B., Hollis-Moffatt, J.E., Miller, A.L., Reid, J., Abkevich, V., Timms, K.M., Gutin, A., Lanchbury, J.S., Merriman, T.R., Barclay, M.L., Kennedy, M.A. Am. J. Gastroenterol. (2007) [Pubmed]
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