Gene Review:
TBX21 - T-box 21
Homo sapiens
Synonyms:
T-PET, T-bet, T-box protein 21, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, ...
Solomou,
Hara,
van de Locht,
Lake,
Richter,
Young,
Glimcher,
Merkx,
Nagafuchi,
Sumimoto,
de Mulder,
Matsuura,
Tantisira,
Hoey,
Stark,
de Wilde,
Scharenborg,
Peng,
Adema,
Takeya,
Raby,
van Herpen,
Callard,
Weiss,
Lee,
Yates,
Zonneveld,
Dorfman,
Glimcher,
Kusuhara,
Looman,
Kohno,
Ihara,
Cousins,
Sasaki,
Drazen,
Hwang,
Hwang,
Kuromaru,
Pravitt Gourh,
Sandeep K. Agarwal,
Dipal Divecha,
Shervin Assassi,
Gene Paz,
Rajpreet K. Arora-Singh,
John D. Reveille,
Sanjay Shete,
Maureen D. Mayes,
Frank C. Arnett,
Filemon K. Tan,
Shahsafaei,
Silverman,
Keyvanfar,
Staynov,
- T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. Rangachari, M., Mauermann, N., Marty, R.R., Dirnhofer, S., Kurrer, M.O., Komnenovic, V., Penninger, J.M., Eriksson, U. J. Exp. Med. (2006)
- T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. Usui, T., Preiss, J.C., Kanno, Y., Yao, Z.J., Bream, J.H., O'Shea, J.J., Strober, W. J. Exp. Med. (2006)
- Expression of the T-cell transcription factors, GATA-3 and T-bet, in the neoplastic cells of Hodgkin lymphomas. Atayar, C., Poppema, S., Blokzijl, T., Harms, G., Boot, M., van den Berg, A. Am. J. Pathol. (2005)
- Sustained T-bet expression confers polarized human TH2 cells with TH1-like cytokine production and migratory capacities. Lametschwandtner, G., Biedermann, T., Schwärzler, C., Günther, C., Kund, J., Fassl, S., Hinteregger, S., Carballido-Perrig, N., Szabo, S.J., Glimcher, L.H., Carballido, J.M. J. Allergy Clin. Immunol. (2004)
- Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making. Yates, A., Callard, R., Stark, J. J. Theor. Biol. (2004)
- Cytokine memory of T helper lymphocytes. Löhning, M., Richter, A., Radbruch, A. Adv. Immunol. (2002)
- A distal conserved sequence element controls ifng gene expression by T cells and NK cells. Hatton, R.D., Harrington, L.E., Luther, R.J., Wakefield, T., Janowski, K.M., Oliver, J.R., Lallone, R.L., Murphy, K.M., Weaver, C.T. Immunity (2006)
- Innate Immune Activation and CD4(+) T Cell Priming during Respiratory Fungal Infection. Rivera, A., Ro, G., Van Epps, H.L., Simpson, T., Leiner, I., Sant'angelo, D.B., Pamer, E.G. Immunity (2006)
- Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Djuretic, I.M., Levanon, D., Negreanu, V., Groner, Y., Rao, A., Ansel, K.M. Nat. Immunol. (2007)
- Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Shinohara, M.L., Lu, L., Bu, J., Werneck, M.B., Kobayashi, K.S., Glimcher, L.H., Cantor, H. Nat. Immunol. (2006)
- TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Tantisira, K.G., Hwang, E.S., Raby, B.A., Silverman, E.S., Lake, S.L., Richter, B.G., Peng, S.L., Drazen, J.M., Glimcher, L.H., Weiss, S.T. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Akahoshi, M., Obara, K., Hirota, T., Matsuda, A., Hasegawa, K., Takahashi, N., Shimizu, M., Nakashima, K., Cheng, L., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Higashi, N., Taniguchi, M., Enomoto, T., Mao, X.Q., Nakashima, H., Adra, C.N., Nakamura, Y., Tamari, M., Shirakawa, T. Hum. Genet. (2005)
- Association analysis of novel TBX21 variants with asthma phenotypes. Chung, H.T., Kim, L.H., Park, B.L., Lee, J.H., Park, H.S., Choi, B.W., Hong, S.J., Chae, S.C., Kim, J.J., Park, C.S., Shin, H.D. Hum. Mutat. (2003)
- Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Faedo, A., Ficara, F., Ghiani, M., Aiuti, A., Rubenstein, J.L., Bulfone, A. Mech. Dev. (2002)
- Cloning and characterization of a new member of the T-box gene family. Zhang, W.X., Yang, S.Y. Genomics (2000)
- Identification of a novel type 1 diabetes susceptibility gene, T-bet. Sasaki, Y., Ihara, K., Matsuura, N., Kohno, H., Nagafuchi, S., Kuromaru, R., Kusuhara, K., Takeya, R., Hoey, T., Sumimoto, H., Hara, T. Hum. Genet. (2004)
- Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Intlekofer, A.M., Takemoto, N., Wherry, E.J., Longworth, S.A., Northrup, J.T., Palanivel, V.R., Mullen, A.C., Gasink, C.R., Kaech, S.M., Miller, J.D., Gapin, L., Ryan, K., Russ, A.P., Lindsten, T., Orange, J.S., Goldrath, A.W., Ahmed, R., Reiner, S.L. Nat. Immunol. (2005)
- T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Tong, Y., Aune, T., Boothby, M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Arora, M., Chen, L., Paglia, M., Gallagher, I., Allen, J.E., Vyas, Y.M., Ray, A., Ray, P. Proc. Natl. Acad. Sci. U.S.A. (2006)
- IFN-{gamma} and T-bet Expression in Human Dendritic Cells from Normal Donors and Cancer Patients Is Controlled through Mechanisms Involving ERK-1/2-Dependent and IL-12-Independent Pathways. Li, H., Wojciechowski, W., Dell'agnola, C., Lopez, N.E., Espinoza-Delgado, I. J. Immunol. (2006)
- Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Chen, G.Y., Osada, H., Santamaria-Babi, L.F., Kannagi, R. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines. Gourh, P., Agarwal, S.K., Divecha, D., Assassi, S., Paz, G., Arora-Singh, R.K., Reveille, J.D., Shete, S., Mayes, M.D., Arnett, F.C., Tan, F.K. Arthritis Rheum. (2009)
- T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia. Solomou, E.E., Keyvanfar, K., Young, N.S. Blood (2006)
- Different antigens trigger different Th1/Th2 reactions in neonatal mononuclear cells (MNCs) relating to T-bet/GATA-3 expression. Yu, H.R., Chang, J.C., Chen, R.F., Chuang, H., Hong, K.C., Wang, L., Yang, K.D. J. Leukoc. Biol. (2003)
- Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation. Takemoto, N., Intlekofer, A.M., Northrup, J.T., Wherry, E.J., Reiner, S.L. J. Immunol. (2006)
- T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity. Gocke, A.R., Cravens, P.D., Ben, L.H., Hussain, R.Z., Northrop, S.C., Racke, M.K., Lovett-Racke, A.E. J. Immunol. (2007)
- Interleukin-12 Drives the Th1 Signaling Pathway in Helicobacter pylori-Infected Human Gastric Mucosa. Pellicanò, A., Sebkova, L., Monteleone, G., Guarnieri, G., Imeneo, M., Pallone, F., Luzza, F. Infect. Immun. (2007)
- Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones. Kitamura, N., Kaminuma, O., Mori, A., Hashimoto, T., Kitamura, F., Miyagishi, M., Taira, K., Miyatake, S. Immunol. Cell Biol. (2005)
- Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. Cousins, D.J., Lee, T.H., Staynov, D.Z. J. Immunol. (2002)
- T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma. Dorfman, D.M., Hwang, E.S., Shahsafaei, A., Glimcher, L.H. Hum. Pathol. (2005)
- Intratumoral administration of recombinant human interleukin 12 in head and neck squamous cell carcinoma patients elicits a T-helper 1 profile in the locoregional lymph nodes. van Herpen, C.M., Looman, M., Zonneveld, M., Scharenborg, N., de Wilde, P.C., van de Locht, L., Merkx, M.A., Adema, G.J., de Mulder, P.H. Clin. Cancer Res. (2004)