The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Hist1h1d  -  histone cluster 1, H1d

Mus musculus

Synonyms: H1 VAR.4, H1.3, H1D, H1d, H1f3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hist1h1d


High impact information on Hist1h1d

  • To determine whether one of these H1s, in particular, was responsible for the compensation present in H1(0-/-) mice, each of the three H1 knockout mouse lines was bred with H1(0) knockout mice to generate H1c/H1(0), H1d/H1(0), or H1e/H1(0) double-knockout mice [3].
  • The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform [4].
  • Most of the H1 histones, namely H1a, H1c, H1d/e, and H1(0), completely aggregate polynucleosomes (1.3 kilobase pairs, 6 nucleosomes) at 270-360 nM, corresponding to a molar ratio of six to eight H1 molecules per reconstituted nucleosome [5].
  • In this system the wild type H1d promoter was 20-fold stronger than the H1t promoter [6].
  • H1b is much less varied, while H1d and H1e are invariant by these electrophoretic criteria [7].

Biological context of Hist1h1d

  • They also show that neither H1b nor H1d is essential for cell division [2].
  • A high degree of nucleotide sequence identity was seen between the H1var.2, rat H1d and human H1b genes, even well beyond the coding region, indicating that these genes are likely homologues [8].
  • Using transient transfection assays in mouse fibroblast NIH3T3 cells, we showed that rat H1d contains a downstream region (+21 to +116) that imparts a two- to threefold up-regulation of fused reporters [9].

Regulatory relationships of Hist1h1d

  • The rat histone H1d gene has intragenic activating sequences that are absent from the testis-specific variant H1t [9].

Other interactions of Hist1h1d

  • Two of the genes that have not been assigned previously to the five somatic H1 subtypes have been identified as encoding the H1b and H1d subtypes [10].

Analytical, diagnostic and therapeutic context of Hist1h1d


  1. In vivo phosphorylation of histone H1 variants during the cell cycle. Talasz, H., Helliger, W., Puschendorf, B., Lindner, H. Biochemistry (1996) [Pubmed]
  2. The H1 histones and their interphase phosphorylated states in differentiated and undifferentiated cell lines derived from murine teratocarcinomas. Lennox, R.W., Oshima, R.G., Cohen, L.H. J. Biol. Chem. (1982) [Pubmed]
  3. Individual somatic H1 subtypes are dispensable for mouse development even in mice lacking the H1(0) replacement subtype. Fan, Y., Sirotkin, A., Russell, R.G., Ayala, J., Skoultchi, A.I. Mol. Cell. Biol. (2001) [Pubmed]
  4. Hormone-mediated dephosphorylation of specific histone H1 isoforms. Banks, G.C., Deterding, L.J., Tomer, K.B., Archer, T.K. J. Biol. Chem. (2001) [Pubmed]
  5. In vitro binding of H1 histone subtypes to nucleosomal organized mouse mammary tumor virus long terminal repeat promotor. Talasz, H., Sapojnikova, N., Helliger, W., Lindner, H., Puschendorf, B. J. Biol. Chem. (1998) [Pubmed]
  6. The testis-specific histone H1t gene is strongly repressed by a G/C-rich region just downstream of the TATA Box. Clare, S.E., Fantz, D.A., Kistler, W.S., Kistler, M.K. J. Biol. Chem. (1997) [Pubmed]
  7. Differences in evolutionary stability among mammalian H1 subtypes. Implications for the roles of H1 subtypes in chromatin. Lennox, R.W. J. Biol. Chem. (1984) [Pubmed]
  8. Isolation and characterization of two replication-dependent mouse H1 histone genes. Dong, Y., Sirotkin, A.M., Yang, Y.S., Brown, D.T., Sittman, D.B., Skoultchi, A.I. Nucleic Acids Res. (1994) [Pubmed]
  9. The rat histone H1d gene has intragenic activating sequences that are absent from the testis-specific variant H1t. Horvath, G.C., Dasgupta, A., Kistler, M.K., Kistler, W.S. Biochim. Biophys. Acta (2003) [Pubmed]
  10. The mouse histone H1 genes: gene organization and differential regulation. Wang, Z.F., Sirotkin, A.M., Buchold, G.M., Skoultchi, A.I., Marzluff, W.F. J. Mol. Biol. (1997) [Pubmed]
WikiGenes - Universities