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Gene Review

IGSF11  -  immunoglobulin superfamily, member 11

Homo sapiens

Synonyms: BT-IgSF, BTIGSF, Brain and testis-specific immunoglobulin superfamily protein, Bt-IGSF, CT119, ...
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Disease relevance of IGSF11


High impact information on IGSF11

  • These results indicate that BT-IgSF functions as a cell adhesion molecule, that its cytoplasmic tail is not essential for the function, and that beta(1) integrin is not involved in the function [3].
  • Flow cytometric analyses with the cells demonstrated that the cell aggregation mediated by BT-IgSF was through homophilic molecular interaction, and in a Ca(2+)/Mg(2+)-independent manner [3].
  • In this study, to explore its function, we generated cells overexpressing BT-IgSF proteins and analyzed their phenotypes [3].
  • The cell aggregates were also observed with mutant BT-IgSF lacking its cytoplasmic tail, the amino acid sequences of which were highly conserved among the BT-IgSF subgroup proteins [3].
  • BT-IgSF is a newly identified cell surface glycoprotein belonging to the immunoglobulin superfamily (IgSF) [3].

Biological context of IGSF11


Anatomical context of IGSF11

  • We have previously shown that the expression of the BT-IgSF gene was highly restricted to brain and testis, and its transcript was detected in both neurons and glial cells [3].

Analytical, diagnostic and therapeutic context of IGSF11

  • These peptides showed IGSF11-specific cytotoxic activity in an HLA-A*0201-restricted fashion, suggesting that these peptides may be applicable for cancer immunotherapy [2].


  1. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]
  2. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. Watanabe, T., Suda, T., Tsunoda, T., Uchida, N., Ura, K., Kato, T., Hasegawa, S., Satoh, S., Ohgi, S., Tahara, H., Furukawa, Y., Nakamura, Y. Cancer Sci. (2005) [Pubmed]
  3. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. Harada, H., Suzu, S., Hayashi, Y., Okada, S. J. Cell. Physiol. (2005) [Pubmed]
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