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Gene Review

Igk-V28  -  immunoglobulin kappa chain variable 28 (V28)

Mus musculus

Synonyms: AV061724, Igk-Ef1, Igk-Trp, Igk-VSer
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Disease relevance of Igk-V28


High impact information on Igk-V28


Biological context of Igk-V28


Anatomical context of Igk-V28


Other interactions of Igk-V28

  • On the basis of these data, the Rn7s-6 sequence may be placed within 1.3 centimorgans of Ly-3 and one of the Igk-V-region markers, Igk-Ef1 [12].
  • The results from the NAK mouse indicate that at least some members of Vk4, Vk8, Vk10, and Vk21 were on one side of the recombination event linked to the Lyt-2 alpha and Igk-Ef1 alpha alleles of AKR, while the Vk9, Vk11, and Vk24 REF patterns came from the NZB parental strain linked to the Igk-Ef2 beta (Vk1) allele [13].
  • The mouse Igk-VSer gene encodes an immunoglobulin kappa light chain variable region which gives rise to two phenotypic polymorphisms of mouse kappa chains [14].
  • Structural and evolutionary comparisons of four alleles of the mouse Igk-J locus which encodes immunoglobulin kappa light chain joining (J kappa) segments [15].

Analytical, diagnostic and therapeutic context of Igk-V28

  • The limit of human IgG detection by inhibition ELISA using mouse anti-human immunoglobulin kappa light chain (Ig kappa) monoclonal antibody is 0.01 microgram [16].


  1. Immunoglobulin kappa light chain variable region gene complex organization and immunoglobulin genes encoding anti-DNA autoantibodies in lupus mice. Kofler, R., Strohal, R., Balderas, R.S., Johnson, M.E., Noonan, D.J., Duchosal, M.A., Dixon, F.J., Theofilopoulos, A.N. J. Clin. Invest. (1988) [Pubmed]
  2. The endogenous retrovirus Mtv-8 on mouse chromosome 6 maps near several kappa light chain markers. Yang, J.N., Boyd, R.T., Gottlieb, P.D., Dudley, J.P. Immunogenetics (1987) [Pubmed]
  3. DNase I-hypersensitive sites in the chromatin of immunoglobulin kappa light chain genes. Chung, S.Y., Folsom, V., Wooley, J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  4. An immunoglobulin promoter displays cell-type specificity independently of the enhancer. Foster, J., Stafford, J., Queen, C. Nature (1985) [Pubmed]
  5. Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. I. Mapping of genes for Id-460 expression to the variable region of immunoglobulin heavy-chain locus and to the variable region of immunoglobulin kappa-light-chain locus. Dzierzak, E.A., Janeway, C.A., Rosenstein, R.W., Gottlieb, P.D. J. Exp. Med. (1980) [Pubmed]
  6. B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment. Weaver, D., Baltimore, D. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  7. Alternative splicing patterns in an aberrantly rearranged immunoglobulin kappa-light-chain gene. Sikder, S.K., Kabat, E.A., Morrison, S.L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  8. Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence. Parslow, T.G., Blair, D.L., Murphy, W.J., Granner, D.K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  9. Mapping of Igk-V genes using backcrossed laboratory and wild mice. Rueff-Juy, D., Drapier, A.M., Cazenave, P.A. Immunogenetics (1988) [Pubmed]
  10. A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus. Schupp, I.W., Schlake, T., Kirschbaum, T., Zachau, H.G., Boehm, T. Immunogenetics (1997) [Pubmed]
  11. Recombination events that activate, diversify, and delete immunoglobulin genes. Leder, P., Max, E.E., Seidman, J.G., Kwan, S.P., Scharff, M., Nau, M., Norman, B. Cold Spring Harb. Symp. Quant. Biol. (1981) [Pubmed]
  12. Linkage of a 7S RNA sequence and kappa light chain genes in the mouse. Taylor, B.A., Rowe, L., Gibson, D.M., Riblet, R., Yetter, R., Gottlieb, P.D. Immunogenetics (1985) [Pubmed]
  13. The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6. D'Hoostelaere, L.A., Gibson, D.M. Immunogenetics (1986) [Pubmed]
  14. Structural and evolutionary comparisons of four alleles of the mouse immunoglobulin kappa chain gene, Igk-VSer. Ponath, P.D., Hillis, D.M., Gottlieb, P.D. Immunogenetics (1989) [Pubmed]
  15. Structural and evolutionary comparisons of four alleles of the mouse Igk-J locus which encodes immunoglobulin kappa light chain joining (J kappa) segments. Ponath, P.D., Boyd, R.T., Hillis, D.M., Gottlieb, P.D. Immunogenetics (1989) [Pubmed]
  16. Species identification of blood and bloodstains by enzyme-linked immunosorbent assay (ELISA) using anti-human immunoglobulin kappa light chain monoclonal antibody. Yamamoto, Y., Tsutsumi, A., Ishizu, H. Forensic Sci. Int. (1989) [Pubmed]
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