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Gene Review

AY498738  -  cDNA sequence AY498738

Mus musculus

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Disease relevance of AY498738


High impact information on AY498738


Biological context of AY498738

  • Multiple members of the NF-kappa B/Rel protein family are induced during B cell differentiation and have been implicated in transcriptional activation of the immunoglobulin kappa (Ig kappa) locus [10].
  • We generated mice harboring germline mutations in which the enhancer element located 9 kb 3' of the immunoglobulin kappa light chain gene (3'E kappa) was replaced either by a single loxP site (3'E kappa delta) or by a neomycin resistance gene (3'E kappa N) [11].
  • We conclude that developmentally controlled transcription of a gene rearrangement in the Ig lambda locus occurs in the presence of an unrearranged Ig kappa locus and is therefore not negatively regulated by the latter [12].
  • In contrast, analysis of two V kappa cDNA libraries prepared from LPS-stimulated adult spleen cells indicates that only 17% of the Ig kappa cDNAs contain sequences belonging to the V kappa 4 gene family [13].
  • Expression of 14-kb Pvt-1 RNA is elevated in B-cell tumor lines that express immunoglobulin light chain genes; thus, we postulate that these translocations are facilitated by the increased DNA accessibility of immunoglobulin kappa light chain and Pvt-1 genes when they are simultaneously expressed at certain times during B-cell ontogeny [14].

Anatomical context of AY498738

  • To understand the basis for this developmental shift away from dependence on enhancer function, we have investigated the relationship between transcriptional activity and methylation status of the immunoglobulin kappa light-chain genes (kappa genes) in mouse cell lines representing different stages of B-cell maturation [15].
  • The V kappa-1A and V kappa-1C germ line genes isolated from BALB/c (Ig kappa c) were identical to those previously described [16].
  • By using a plasmid harboring a portion of the Ig kappa gene within which MAR had been located, we searched for proteins recognizing MAR in the nuclear scaffold components electrophoretically separated and blotted onto a membrane [17].
  • The Ig kappa L chain synthesized by the mouse hybridoma line F10 forms large fibrils in the lumen of the endoplasmic reticulum [18].
  • The pre-B lymphoid cell line 70Z/3 was previously shown to express type II IL-1R and responds to IL-1 alpha by expressing immunoglobulin kappa light chain mRNA and increased levels of surface IgM [19].

Associations of AY498738 with chemical compounds


Physical interactions of AY498738

  • Using a battery of congenic and inbred strains, it was shown that the QUPC52 idiotype was controlled by genes linked to the Igh complex locus (chromosome 12) and to the Ig kappa complex locus (chromosome 6) [23].

Regulatory relationships of AY498738


Other interactions of AY498738


Analytical, diagnostic and therapeutic context of AY498738

  • Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa [31].
  • To determine whether an affinity-based process explained the differences in kappa/lambda ratios seen, we measured the affinity of Ig kappa and Ig lambda antibody by using the binding ratio radioimmunoassay method, which measures the affinity of antibodies of particular isotypes without the need for prior purification [32].
  • Ig kappa loci sequence analysis was also performed from 10 additional variants amplified directly from tumor cells in vitro without immunoselection [33].
  • In nuclei and NM, a number of the same polypeptides were recognized on a southwestern blot when MAR of immunoglobulin kappa gene (Ig kappa MAR) and pericentromeric (periCEN) satDNA fragments were used [34].
  • Species identification of blood and bloodstains by enzyme-linked immunosorbent assay (ELISA) using anti-human immunoglobulin kappa light chain monoclonal antibody [35].


  1. Inhibition of NF-kappa B by sodium salicylate and aspirin. Kopp, E., Ghosh, S. Science (1994) [Pubmed]
  2. Burkitt lymphoma in the mouse. Kovalchuk, A.L., Qi, C.F., Torrey, T.A., Taddesse-Heath, L., Feigenbaum, L., Park, S.S., Gerbitz, A., Klobeck, G., Hoertnagel, K., Polack, A., Bornkamm, G.W., Janz, S., Morse, H.C. J. Exp. Med. (2000) [Pubmed]
  3. Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus. Graham, M., Adams, J.M. EMBO J. (1986) [Pubmed]
  4. Whole-body autoradiography reveals that the Peptostreptococcus magnus immunoglobulin-binding domains of protein L preferentially target B lymphocytes in the spleen and lymph nodes in vivo. Smith, D., D'Argy, R., Nilsson, M., Yrlid, U., de Jersey, J., Björck, L., Wick, M.J. Cell. Microbiol. (2004) [Pubmed]
  5. Monoclonal autoantibodies from patients with autoimmune diseases: synovial fluid B lymphocytes of a patient with rheumatoid arthritis produced an IgG lambda antibody recognizing J-sequences of Ig kappa chains in a conformation-dependent way. von Landenberg, P., Rzepka, R., Melchers, I. Immunobiology (1999) [Pubmed]
  6. Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes. Cross, S.L., Halden, N.F., Lenardo, M.J., Leonard, W.J. Science (1989) [Pubmed]
  7. Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Kranz, D.M., Saito, H., Disteche, C.M., Swisshelm, K., Pravtcheva, D., Ruddle, F.H., Eisen, H.N., Tonegawa, S. Science (1985) [Pubmed]
  8. The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. Michael, N., Shen, H.M., Longerich, S., Kim, N., Longacre, A., Storb, U. Immunity (2003) [Pubmed]
  9. In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation. Shaffer, A.L., Peng, A., Schlissel, M.S. Immunity (1997) [Pubmed]
  10. Corepression of RelA and c-rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes. Scherer, D.C., Brockman, J.A., Bendall, H.H., Zhang, G.M., Ballard, D.W., Oltz, E.M. Immunity (1996) [Pubmed]
  11. The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Gorman, J.R., van der Stoep, N., Monroe, R., Cogne, M., Davidson, L., Alt, F.W. Immunity (1996) [Pubmed]
  12. Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. Oberdoerffer, P., Novobrantseva, T.I., Rajewsky, K. J. Exp. Med. (2003) [Pubmed]
  13. Preferential rearrangement of V kappa 4 gene segments in pre-B cell lines. Kalled, S.L., Brodeur, P.H. J. Exp. Med. (1990) [Pubmed]
  14. Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas. Huppi, K., Siwarski, D., Skurla, R., Klinman, D., Mushinski, J.F. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  15. The coupling between enhancer activity and hypomethylation of kappa immunoglobulin genes is developmentally regulated. Kelley, D.E., Pollok, B.A., Atchison, M.L., Perry, R.P. Mol. Cell. Biol. (1988) [Pubmed]
  16. Characterization of allelic V kappa-1 region genes in inbred strains of mice. Ng, K.H., Lavigueur, A., Ricard, L., Boivrette, M., Maclean, S., Cloutier, D., Gibson, D.M. J. Immunol. (1989) [Pubmed]
  17. Identification and characterization of a nuclear scaffold protein that binds the matrix attachment region DNA. Tsutsui, K., Tsutsui, K., Okada, S., Watarai, S., Seki, S., Yasuda, T., Shohmori, T. J. Biol. Chem. (1993) [Pubmed]
  18. Large cytoplasmic inclusion body kappa-chain has unusual intrachain disulfide bonding. Jäck, H.M., Sloan, B., Grisham, G., Reason, D., Wabl, M. J. Immunol. (1993) [Pubmed]
  19. Comparison of IL-1 alpha effectiveness in activating murine pre-B and T cell lines. Iwasaki, T., Sims, J.E., Grabstein, K., Dower, S.K., Rachie, N., Bomsztyk, K. Cytokine (1993) [Pubmed]
  20. Lipopolysaccharide-unresponsive mutant pre-B-cell lines blocked in NF-kappa B activation. Briskin, M., Damore, M., Law, R., Lee, G., Kincade, P.W., Sibley, C.H., Kuehl, M., Wall, R. Mol. Cell. Biol. (1990) [Pubmed]
  21. Pentoxifylline inhibits Ig kappa gene transcription and rearrangements in pre-B cells. Wang, W., Rath, S., Durdik, J.M., Sen, R. J. Immunol. (1998) [Pubmed]
  22. Lambda5 is required for rearrangement of the Ig kappa light chain gene in pro-B cell lines. Miyazaki, T., Kato, I., Takeshita, S., Karasuyama, H., Kudo, A. Int. Immunol. (1999) [Pubmed]
  23. Genetics of the alpha 1,6-dextran response: expression of the QUPC52 idiotype in different inbred and congenic strains of mice. D'Hoostelaere, L., Potter, M. J. Immunol. (1982) [Pubmed]
  24. Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines. Miyamoto, S., Chiao, P.J., Verma, I.M. Mol. Cell. Biol. (1994) [Pubmed]
  25. The IRG-47 gene is IFN-gamma induced in B cells and encodes a protein with GTP-binding motifs. Gilly, M., Wall, R. J. Immunol. (1992) [Pubmed]
  26. Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. Bai, Y., Srinivasan, L., Perkins, L., Atchison, M.L. J. Immunol. (2005) [Pubmed]
  27. Juxtaposition of N-myc and Ig kappa through a reciprocal t(6;12) translocation in a mouse plasmacytoma. Axelson, H., Wang, Y., Silva, S., Mattei, M.G., Klein, G. Genes Chromosomes Cancer (1994) [Pubmed]
  28. Interleukin-2 may enhance or inhibit antibody production by B cells depending on intracellular cAMP concentrations. Dennig, D., Mecheri, S., Bourhis, J.H., Hoffman, M.K. Immunology (1992) [Pubmed]
  29. Inhibition of murine K-BALB and CT26 tumour growth using a Semliki Forest virus vector with enhanced expression of IL-18. Chikkanna-Gowda, C.P., McNally, S., Sheahan, B.J., Fleeton, M.N., Atkins, G.J. Oncol. Rep. (2006) [Pubmed]
  30. IgM RNA switch from membrane to secretory form is prevented by adding antireceptor antibody to bacterial lipopolysaccharide-stimulated murine primary B-cell cultures. Chen-Bettecken, U., Wecker, E., Schimpl, A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  31. Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. Zou, Y.R., Takeda, S., Rajewsky, K. EMBO J. (1993) [Pubmed]
  32. T cell regulation of light chain expression: preferential enhancement of Ig kappa in a primary thymus-dependent response does not require affinity-based selection. Burkly, L.C., Nikolic, J., Wortis, H.H. J. Immunol. (1985) [Pubmed]
  33. Molecular characterization of anti-idiotype antibody-resistant variants of a murine B cell lymphoma. Roth, M.S., Weiner, G.J., Allen, E.A., Terry, V.H., Harnden, C.E., Boehnke, M., Kaminski, M.S., Ginsburg, D. J. Immunol. (1990) [Pubmed]
  34. Specificity of SAF-A and lamin B binding in vitro correlates with the satellite DNA bending state. Lobov, I.B., Tsutsui, K., Mitchell, A.R., Podgornaya, O.I. J. Cell. Biochem. (2001) [Pubmed]
  35. Species identification of blood and bloodstains by enzyme-linked immunosorbent assay (ELISA) using anti-human immunoglobulin kappa light chain monoclonal antibody. Yamamoto, Y., Tsutsumi, A., Ishizu, H. Forensic Sci. Int. (1989) [Pubmed]
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