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Il10rb  -  interleukin 10 receptor, beta

Mus musculus

Synonyms: 6620401D04Rik, AI528744, CRF2-4, Crfb4, Cytokine receptor class-II member 4, ...
 
 
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High impact information on Il10rb

 

Biological context of Il10rb

  • The structure of the Il10r2 gene was deduced and consisted of 7 exons and 6 introns arrayed in an organization similar to its human ortholog [6].
  • We also present a revised Il10r2 cDNA sequence with a total of 100 bp of additional nucleotide sequence in the 5' and 3' untranslated regions, and report the first extensive profiles of Il10r2 and Ifnar1 mRNA developmental stage and adult tissue expression [6].
 

Analytical, diagnostic and therapeutic context of Il10rb

  • PCR cloning and sequencing of partial rat IL-10R and CRF2-4 cDNAs revealed 86% homology with corresponding mouse sequences [4].
  • IL-10R mRNA expression, as confirmed by immunohistochemistry, was induced 20.1- and 8.6-fold in HSC from cholestatic livers and 7-day culture-activated HSC, respectively but CRF2-4 mRNA levels were unchanged [4].

References

  1. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. Spencer, S.D., Di Marco, F., Hooley, J., Pitts-Meek, S., Bauer, M., Ryan, A.M., Sordat, B., Gibbs, V.C., Aguet, M. J. Exp. Med. (1998) [Pubmed]
  2. Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses. Kang, S.S., Allen, P.M. J. Immunol. (2005) [Pubmed]
  3. Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation. Ding, Y., Qin, L., Zamarin, D., Kotenko, S.V., Pestka, S., Moore, K.W., Bromberg, J.S. J. Immunol. (2001) [Pubmed]
  4. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Mathurin, P., Xiong, S., Kharbanda, K.K., Veal, N., Miyahara, T., Motomura, K., Rippe, R.A., Bachem, M.G., Tsukamoto, H. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  5. CRF2-4: isolation of cDNA clones encoding the human and mouse proteins. Gibbs, V.C., Pennica, D. Gene (1997) [Pubmed]
  6. Characterization and transcriptional analysis of the mouse Chromosome 16 cytokine receptor gene cluster. Hardy, M.P., Sanij, E.P., Hertzog, P.J., Owczarek, C.M. Mamm. Genome (2003) [Pubmed]
 
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