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Gene Review

Ins1  -  insulin I

Mus musculus

Synonyms: Ins-1, Ins2-rs1, Insulin-1
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Disease relevance of Ins1

  • Dietary antioxidant supplementation was protective against pancreatic angiogenesis, hyperinsulinemia, and subsequent activation of insulin signaling cascades in peripheral tissues [1].

High impact information on Ins1


Associations of Ins1 with chemical compounds

  • Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity [7].
  • These studies demonstrate that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation [8].

Other interactions of Ins1

  • The beta-cell mass in Ins2-/- mice was increased almost threefold, which accounts for the increase of Ins1 transcripts in Ins2-/-mutants [9].


  1. Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling. Laurent, G., Solari, F., Mateescu, B., Karaca, M., Castel, J., Bourachot, B., Magnan, C., Billaud, M., Mechta-Grigoriou, F. Cell Metab. (2008) [Pubmed]
  2. Phenotypic alterations in insulin-deficient mutant mice. Duvillié, B., Cordonnier, N., Deltour, L., Dandoy-Dron, F., Itier, J.M., Monthioux, E., Jami, J., Joshi, R.L., Bucchini, D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2. Deltour, L., Montagutelli, X., Guenet, J.L., Jami, J., Páldi, A. Dev. Biol. (1995) [Pubmed]
  4. Genetic reassignment of the insulin-1 (Ins1) gene to distal mouse chromosome 19. Davies, P.O., Poirier, C., Deltour, L., Montagutelli, X. Genomics (1994) [Pubmed]
  5. Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. Weiss, H., Bleich, A., Hedrich, H.J., Kölsch, B., Elsner, M., Jörns, A., Lenzen, S., Tiedge, M., Wedekind, D. Mamm. Genome (2005) [Pubmed]
  6. Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice. Deltour, L., Vandamme, J., Jouvenot, Y., Duvillié, B., Kelemen, K., Schaerly, P., Jami, J., Paldi, A. Gene Expr. Patterns (2004) [Pubmed]
  7. Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. Nakayama, M., Beilke, J.N., Jasinski, J.M., Kobayashi, M., Miao, D., Li, M., Coulombe, M.G., Liu, E., Elliott, J.F., Gill, R.G., Eisenbarth, G.S. J. Clin. Invest. (2007) [Pubmed]
  8. Central insulin action regulates peripheral glucose and fat metabolism in mice. Koch, L., Wunderlich, F.T., Seibler, J., Könner, A.C., Hampel, B., Irlenbusch, S., Brabant, G., Kahn, C.R., Schwenk, F., Brüning, J.C. J. Clin. Invest. (2008) [Pubmed]
  9. Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Leroux, L., Desbois, P., Lamotte, L., Duvillié, B., Cordonnier, N., Jackerott, M., Jami, J., Bucchini, D., Joshi, R.L. Diabetes (2001) [Pubmed]
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