Disease relevance of Ins1

• Dietary antioxidant supplementation was protective against pancreatic angiogenesis, hyperinsulinemia, and subsequent activation of insulin signaling cascades in peripheral tissues [1].

High impact information on Ins1

• Two mouse insulin genes, Ins1 and Ins2, were disrupted and lacZ was inserted at the Ins2 locus by gene targeting [2].
• At Days 12.5, 13.5, and 14.5 of gestation, expression of both parental alleles of both Ins1 and Ins2 was detected in the bodies of the embryos [3].
• Genetic reassignment of the insulin-1 (Ins1) gene to distal mouse chromosome 19 [4].
• The first susceptibility locus on rat Chromosome (RNO) 1 (LOD score 4.13) mapped to the region 1q51-55, which codes for potential candidate genes like Ins1 and Nkx2-3 [5].
• We found that Ins1 is not expressed in the yolk sac of several laboratory mouse strains [6].

Associations of Ins1 with chemical compounds

• Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity [7].
• These studies demonstrate that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation [8].

Other interactions of Ins1

• The beta-cell mass in Ins2-/- mice was increased almost threefold, which accounts for the increase of Ins1 transcripts in Ins2-/-mutants [9].

References