Gene Review:
Kcna5 - potassium voltage-gated channel, shaker...
Mus musculus
Synonyms:
KV1-5, Kv1.5, Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel subunit Kv1.5
- A cellular model for long QT syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum. Folco, E., Mathur, R., Mori, Y., Buckett, P., Koren, G. J. Biol. Chem. (1997)
- Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Hulme, J.T., Coppock, E.A., Felipe, A., Martens, J.R., Tamkun, M.M. Circ. Res. (1999)
- Long-term restitution of 4-aminopyridine-sensitive currents in Kv1DN ventricular myocytes using adeno-associated virus-mediated delivery of Kv1.5. Kodirov, S.A., Brunner, M., Busconi, L., Koren, G. FEBS Lett. (2003)
- Kv1.5 channelopathy due to KCNA5 loss-of-function mutation causes human atrial fibrillation. Olson, T.M., Alekseev, A.E., Liu, X.K., Park, S., Zingman, L.V., Bienengraeber, M., Sattiraju, S., Ballew, J.D., Jahangir, A., Terzic, A. Hum. Mol. Genet. (2006)
- Electrical remodeling and arrhythmias in long-QT syndrome: lessons from genetic models in mice. Koren, G. Ann. Med. (2004)
- Permeation selectivity by competition in a delayed rectifier potassium channel. Korn, S.J., Ikeda, S.R. Science (1995)
- Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. Archer, S.L., Souil, E., Dinh-Xuan, A.T., Schremmer, B., Mercier, J.C., El Yaagoubi, A., Nguyen-Huu, L., Reeve, H.L., Hampl, V. J. Clin. Invest. (1998)
- Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. Peretz, A., Gil-Henn, H., Sobko, A., Shinder, V., Attali, B., Elson, A. EMBO J. (2000)
- Constitutive activation of delayed-rectifier potassium channels by a src family tyrosine kinase in Schwann cells. Sobko, A., Peretz, A., Attali, B. EMBO J. (1998)
- External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Honoré, E., Barhanin, J., Attali, B., Lesage, F., Lazdunski, M. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Molecular genetic analysis of distal mouse chromosome 6 defines gene order and positions of the deafwaddler and opisthotonos mutations. Street, V.A., Robinson, L.C., Erford, S.K., Tempel, B.L. Genomics (1995)
- KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels. Li, H., Guo, W., Mellor, R.L., Nerbonne, J.M. J. Mol. Cell. Cardiol. (2005)
- Tyrosine kinases modulate K+ channel gating in mouse Schwann cells. Peretz, A., Sobko, A., Attali, B. J. Physiol. (Lond.) (1999)
- Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits. Uebele, V.N., England, S.K., Chaudhary, A., Tamkun, M.M., Snyders, D.J. J. Biol. Chem. (1996)
- Isoform-specific localization of voltage-gated K+ channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae. Martens, J.R., Sakamoto, N., Sullivan, S.A., Grobaski, T.D., Tamkun, M.M. J. Biol. Chem. (2001)
- The effects of putative K+ channel blockers on volume regulation of murine spermatozoa. Barfield, J.P., Yeung, C.H., Cooper, T.G. Biol. Reprod. (2005)
- Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume. Felipe, A., Snyders, D.J., Deal, K.K., Tamkun, M.M. Am. J. Physiol. (1993)
- The distribution of ganglioside-like moieties in peripheral nerves. Sheikh, K.A., Deerinck, T.J., Ellisman, M.H., Griffin, J.W. Brain (1999)
- Selective elimination of I(K,slow1) in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit. Li, H., Guo, W., Yamada, K.A., Nerbonne, J.M. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Functional and molecular expression of a voltage-dependent K(+) channel (Kv1.1) in interstitial cells of Cajal. Hatton, W.J., Mason, H.S., Carl, A., Doherty, P., Latten, M.J., Kenyon, J.L., Sanders, K.M., Horowitz, B. J. Physiol. (Lond.) (2001)
- Molecular diversity of the repolarizing voltage-gated K+ currents in mouse atrial cells. Bou-Abboud, E., Li, H., Nerbonne, J.M. J. Physiol. (Lond.) (2000)
- Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. Sobko, A., Peretz, A., Shirihai, O., Etkin, S., Cherepanova, V., Dagan, D., Attali, B. J. Neurosci. (1998)
- Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. Leicher, T., Bähring, R., Isbrandt, D., Pongs, O. J. Biol. Chem. (1998)
- Sex and strain differences in adult mouse cardiac repolarization: importance of androgens. Brouillette, J., Rivard, K., Lizotte, E., Fiset, C. Cardiovasc. Res. (2005)
- Mice display sex differences in halothane-induced polymorphic ventricular tachycardia. Drici, M.D., Baker, L., Plan, P., Barhanin, J., Romey, G., Salama, G. Circulation (2002)
- Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation. London, B., Guo, W., Pan Xh, n.u.l.l., Lee, J.S., Shusterman, V., Rocco, C.J., Logothetis, D.A., Nerbonne, J.M., Hill, J.A. Circ. Res. (2001)
- Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels. Thorne, G.D., Conforti, L., Paul, R.J. Am. J. Physiol. Heart Circ. Physiol. (2002)
- Identification, cloning and expression of rabbit vascular smooth muscle Kv1.5 and comparison with native delayed rectifier K+ current. Clément-Chomienne, O., Ishii, K., Walsh, M.P., Cole, W.C. J. Physiol. (Lond.) (1999)
- Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH. Kwan, D.C., Fedida, D., Kehl, S.J. Biophys. J. (2006)
- Presence of the Kv1.5 K(+) channel in the sinoatrial node. Dobrzynski, H., Rothery, S.M., Marples, D.D., Coppen, S.R., Takagishi, Y., Honjo, H., Tamkun, M.M., Henderson, Z., Kodama, I., Severs, N.J., Boyett, M.R. J. Histochem. Cytochem. (2000)