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Kcna2  -  potassium voltage-gated channel, shaker...

Mus musculus

Synonyms: Akr6a4, ENSMUSG00000074335, Gm10672, Kca1-2, Kv1.2, ...
 
 
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Disease relevance of Kcna2

 

Psychiatry related information on Kcna2

  • In chronic electroconvulsive shock-treated rats, Kv1.2 messenger RNA abundance showed similar changes to those in acute electroconvulsive shock: it was reduced 6 h after the last shock and had recovered after 24 h [4].
 

High impact information on Kcna2

  • A family of three closely related potassium channel genes (MK1, MK2, and MK3) that are encoded at distinct genomic loci has been isolated [5].
  • Currents expressed in naive CD4(+) lymphocytes are consistent with Kv1.1, Kv1.2, Kv1.3, and Kv1 [6].
  • These structural changes were accompanied by a marked reduction of contactin-associated protein/paranodin, neurofascin 155 (NF155), and the potassium channel Kv1.2, whereas nodal clusters of sodium channels were unaltered [7].
  • We characterized heteromultimeric channel complexes that consist of either Kv1.5 and Kv1.2 or Kv1.5 and Kv1 [8].
  • 4. In postnatal day 4 (P4) sciatic nerve, most of the Kv1.2 channel subunits are involved in heteromultimeric association with Kv1 [8].
 

Biological context of Kcna2

 

Anatomical context of Kcna2

 

Associations of Kcna2 with chemical compounds

  • The "fast" K+ channel blocker 4-aminopyridine, the toxin DTX-I, which targets the Kv1.1 and Kv1.2, but not DTX- K, which has higher selectivity for Kv1.1, increased the amplitude and area of CAPs of shiverer mice spinal cord axons but had insignificant effects in wild-type mice [16].
 

Other interactions of Kcna2

  • The IKL remaining in -/- neurons was blocked by DTX, suggesting the underlying channels contained subunits Kv1.2 and/or Kv1.6 (also DTX-sensitive) [17].
  • 1, Kv1.2 and their beta2 subunit are localized to the juxtaparanode [18].
  • Coimmunoprecipitation experiments showed that Kv1.2 and Kvbeta1.1 interact in these tissues [19].
  • Kv beta1.1/Kv beta2 double knockouts had significantly increased mortality compared with either single knockout but still maintained surface expression of Kv1.2, indicating that trafficking of this alpha subunit does not require either Kv beta subunit [20].
  • Cx29 displayed a striking coincidence with Kv1.2 K(+) channels, which are localized in the axonal membrane [21].
 

Analytical, diagnostic and therapeutic context of Kcna2

  • RT PCR on mRNA from enzymatically dissociated, isolated bipolar cells showed that these neurons express the Shaker-like K+ channels Kv1.1, Kv1.2, and Kv1 [22].
  • Confocal immunohistochemistry showed that, unlike wild-type mice, which have a precise juxtaparanodal localization of the Kv1.l and Kv1.2 K+ channel subunits, shiverer mouse axons displayed a dispersed distribution of these subunits along the internodes [16].
  • PS/2, R1-2, or MK2 significantly inhibited the recruitment of eosinophils and lymphocytes into the bronchoalveolar lavage (BAL) fluid and decreased inflammation in the lung tissues [23].

References

  1. Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations. Kleopa, K.A., Elman, L.B., Lang, B., Vincent, A., Scherer, S.S. Brain (2006) [Pubmed]
  2. A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product. Tomomura, M., Kadomatsu, K., Matsubara, S., Muramatsu, T. J. Biol. Chem. (1990) [Pubmed]
  3. Oxygen sensitivity of cloned voltage-gated K(+) channels expressed in the pulmonary vasculature. Hulme, J.T., Coppock, E.A., Felipe, A., Martens, J.R., Tamkun, M.M. Circ. Res. (1999) [Pubmed]
  4. Differential effects of acute and chronic electroconvulsive shock on the abundance of messenger RNAs for voltage-dependent potassium channel subunits in the rat brain. Pei, Q., Burnet, P.W., Grahame-Smith, D.G., Zetterström, T.S. Neuroscience (1997) [Pubmed]
  5. A family of three mouse potassium channel genes with intronless coding regions. Chandy, K.G., Williams, C.B., Spencer, R.H., Aguilar, B.A., Ghanshani, S., Tempel, B.L., Gutman, G.A. Science (1990) [Pubmed]
  6. Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation. Liu, Q.H., Fleischmann, B.K., Hondowicz, B., Maier, C.C., Turka, L.A., Yui, K., Kotlikoff, M.I., Wells, A.D., Freedman, B.D. J. Exp. Med. (2002) [Pubmed]
  7. The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system. Schaeren-Wiemers, N., Bonnet, A., Erb, M., Erne, B., Bartsch, U., Kern, F., Mantei, N., Sherman, D., Suter, U. J. Cell Biol. (2004) [Pubmed]
  8. Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation. Sobko, A., Peretz, A., Shirihai, O., Etkin, S., Cherepanova, V., Dagan, D., Attali, B. J. Neurosci. (1998) [Pubmed]
  9. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. Guo, W., Xu, H., London, B., Nerbonne, J.M. J. Physiol. (Lond.) (1999) [Pubmed]
  10. Genetic analysis of the mammalian K+ channel beta subunit Kvbeta 2 (Kcnab2). McCormack, K., Connor, J.X., Zhou, L., Ho, L.L., Ganetzky, B., Chiu, S.Y., Messing, A. J. Biol. Chem. (2002) [Pubmed]
  11. Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels. M'Barek, S., Mosbah, A., Sandoz, G., Fajloun, Z., Olamendi-Portugal, T., Rochat, H., Sampieri, F., Guijarro, J.I., Mansuelle, P., Delepierre, M., De Waard, M., Sabatier, J.M. Eur. J. Biochem. (2003) [Pubmed]
  12. Recent progress on the molecular organization of myelinated axons. Scherer, S.S., Arroyo, E.J. J. Peripher. Nerv. Syst. (2002) [Pubmed]
  13. Immunohistochemical study on the distribution of the voltage-gated potassium channels in the gerbil cerebellum. Chung, Y.H., Joo, K.M., Nam, R.H., Kim, Y.S., Lee, W.B., Cha, C.I. Neurosci. Lett. (2005) [Pubmed]
  14. Internodal specializations of myelinated axons in the central nervous system. Arroyo, E.J., Xu, T., Poliak, S., Watson, M., Peles, E., Scherer, S.S. Cell Tissue Res. (2001) [Pubmed]
  15. Localization of Kv1.1 and Kv1.2, two K channel proteins, to synaptic terminals, somata, and dendrites in the mouse brain. Wang, H., Kunkel, D.D., Schwartzkroin, P.A., Tempel, B.L. J. Neurosci. (1994) [Pubmed]
  16. Functional changes in genetically dysmyelinated spinal cord axons of shiverer mice: role of juxtaparanodal Kv1 family K+ channels. Sinha, K., Karimi-Abdolrezaee, S., Velumian, A.A., Fehlings, M.G. J. Neurophysiol. (2006) [Pubmed]
  17. Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1. Brew, H.M., Hallows, J.L., Tempel, B.L. J. Physiol. (Lond.) (2003) [Pubmed]
  18. Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr. Arroyo, E.J., Xu, Y.T., Zhou, L., Messing, A., Peles, E., Chiu, S.Y., Scherer, S.S. J. Neurocytol. (1999) [Pubmed]
  19. Ion channel proteins in mouse and human vestibular tissue. Hotchkiss, K., Harvey, M., Pacheco, M., Sokolowski, B. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (2005) [Pubmed]
  20. Genetic modifiers of the Kv beta2-null phenotype in mice. Connor, J.X., McCormack, K., Pletsch, A., Gaeta, S., Ganetzky, B., Chiu, S.Y., Messing, A. Genes Brain Behav. (2005) [Pubmed]
  21. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. Altevogt, B.M., Kleopa, K.A., Postma, F.R., Scherer, S.S., Paul, D.L. J. Neurosci. (2002) [Pubmed]
  22. The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current. Klumpp, D.J., Song, E.J., Ito, S., Sheng, M.H., Jan, L.Y., Pinto, L.H. J. Neurosci. (1995) [Pubmed]
  23. Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1. Chin, J.E., Hatfield, C.A., Winterrowd, G.E., Brashler, J.R., Vonderfecht, S.L., Fidler, S.F., Griffin, R.L., Kolbasa, K.P., Krzesicki, R.F., Sly, L.M., Staite, N.D., Richards, I.M. Am. J. Physiol. (1997) [Pubmed]
 
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