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Gene Review:

Cyp3a9 - cytochrome P450, family 3, subfamily a,...

Rattus norvegicus

Synonyms: 3AH15, CYPIIIA9, Cyp3a13, Cytochrome P450 3A9, Cytochrome P450 olfactive 3, ...

Mahnke, A. et al., Wang, H. et al., Gushchin, G.V. et al., Wang, H. et al., Cassel, S. et al., et al.

Cassel, Revel, Kelche, Zwiller, Gushchin, Gushchin, Gerber, Boyd,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cyp3a13

Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli [1].

Psychiatry related information on Cyp3a13

Insights into gender bias: rat cytochrome P450 3A9 [2].

High impact information on Cyp3a13

Except in the olfactive nuclei, very few cells showed detectable MeCP2 protein at birth [3].
Sequencing of a 285 bp coding fragment of this gene revealed 97% similarity with rat olfactory CYP3A9 (P450olf3) [4].
Quantitative reverse-transcriptase polymerase chain reaction was used to determine the content of mRNA derived from four CYP3A genes (CYP3A2, CYP3A9, CYP3A18, and CYP3A23) in rat liver [5].
CYP3A9 induction was different from other CYP3A isoenzymes, since phenobarbital was a more effective inducer than dexamethasone and clotrimazole [5].
Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones [6].

Biological context of Cyp3a13

CYP3A2 and CYP3A9 gene expression was age- and sex-dependent, whereas CYP3A18 and CYP3A23 mRNA were observed before and after puberty at fairly constant levels that were about 20% higher in males than in females [5].

References

Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Wang, H., Strobel, H.W. Arch. Biochem. Biophys. (1997) [Pubmed]
Insights into gender bias: rat cytochrome P450 3A9. Anakk, S., Ku, C.Y., Vore, M., Strobel, H.W. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study. Cassel, S., Revel, M.O., Kelche, C., Zwiller, J. Neurobiol. Dis. (2004) [Pubmed]
A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes. Gushchin, G.V., Gushchin, M.I., Gerber, N., Boyd, R.T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Mahnke, A., Strotkamp, D., Roos, P.H., Hanstein, W.G., Chabot, G.G., Nef, P. Arch. Biochem. Biophys. (1997) [Pubmed]
Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. Wang, H., Napoli, K.L., Strobel, H.W. Mol. Cell. Biochem. (2000) [Pubmed]

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cyp3a65	Danio rerio
CYP3A7	Gallus gallus
CYP3A7	Homo sapiens
Cyp3a13	Mus musculus
Os02g0221900	Oryza sativa Japonica Group
LOC100608616	Pan troglodytes
cyp3a4	Xenopus (Silurana) tropicalis
LOC100487665	Xenopus (Silurana) tropicalis
LOC100494419	Xenopus (Silurana) tropicalis

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