Gene Review:
Cyp3a23/3a1 - cytochrome P450, family 3, subfamily a,...
Rattus norvegicus
Synonyms:
CYP, CYP3A23, CYPIIIA1, Cyp3a-1, Cyp3a1, ...
- Pharmacokinetics of omeprazole after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. Lee, D.Y., Lee, I., Lee, M.G. International journal of pharmaceutics (2007)
- Downregulation of Hepatic Cytochrome P-450 Isoforms and PPAR-gamma: Their Role in Hepatic Injury and Proinflammatory Responses in a Double-Hit Model of Hemorrhage and Sepsis. Higuchi, S., Wu, R., Zhou, M., Ravikumar, T.S., Wang, P. J. Surg. Res. (2007)
- Transformation of rat liver epithelial cells by Kirsten murine sarcoma virus. Rhim, J.S., Kim, C.M., Okigaki, T., Huebner, R.J. J. Natl. Cancer Inst. (1977)
- Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin. Moncion, A., Truong, N.T., Garrone, A., Beaune, P., Barouki, R., De Waziers, I. J. Biol. Chem. (2002)
- Effect of chronic hypoxia on detoxication enzymes in rat liver. Shan, X., Aw, T.Y., Smith, E.R., Ingelman-Sundberg, M., Mannervik, B., Iyanagi, T., Jones, D.P. Biochem. Pharmacol. (1992)
- Differential inducibility of specific mRNA corresponding to five CYP3A isoforms in female rat liver by RU486 and food deprivation: comparison with protein abundance and enzymic activities. Cheesman, M.J., Reilly, P.E. Biochem. Pharmacol. (1998)
- Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Granville, D.J., Tashakkor, B., Takeuchi, C., Gustafsson, A.B., Huang, C., Sayen, M.R., Wentworth, P., Yeager, M., Gottlieb, R.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Huss, J.M., Wang, S.I., Astrom, A., McQuiddy, P., Kasper, C.B. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes. Burger, H.J., Schuetz, J.D., Schuetz, E.G., Guzelian, P.S. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs. Zhang, M., Ballard, M.E., Pan, L., Roberts, S., Faghih, R., Cowart, M., Esbenshade, T.A., Fox, G.B., Decker, M.W., Hancock, A.A., Rueter, L.E. Brain Res. (2005)
- Enhanced regional expression of glutathione S-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria. Thomas, R.S., Gustafson, D.L., Ramsdell, H.S., el-Masri, H.A., Benjamin, S.A., Yang, R.S. Toxicol. Appl. Pharmacol. (1998)
- Lack of evidence for induction of CYP2B1, CYP3A23, and CYP1A2 gene expression by Panax ginseng and Panax quinquefolius extracts in adult rats and primary cultures of rat hepatocytes. Yu, C.T., Chen, J., Teng, X.W., Tong, V., Chang, T.K. Drug Metab. Dispos. (2005)
- In vitro rat hepatic and intestinal metabolism of the organophosphate pesticides chlorpyrifos and diazinon. Poet, T.S., Wu, H., Kousba, A.A., Timchalk, C. Toxicol. Sci. (2003)
- Effects of glucose on blood pressure and production of vascular aldosterone and corticosterone. Zhang, Y., Chu, L., Yu, W., Pang, J. Horm. Res. (2004)
- Differences in transactivation between rat CYP3A1 and human CYP3A4 genes by human pregnane X receptor. Takada, T., Ogino, M., Miyata, M., Shimada, M., Nagata, K., Yamazoe, Y. Drug Metab. Pharmacokinet. (2004)
- cDNA cloning and characterization of a novel member of steroid-induced cytochrome P450 3A in rats. Kirita, S., Matsubara, T. Arch. Biochem. Biophys. (1993)
- Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A. Stevens, G.J., Burkey, J.L., McQueen, C.A. Cell Biol. Toxicol. (2000)
- Mechanism of arsenite-mediated decreases in CYP3A23 in rat hepatocytes. Noreault, T.L., Jacobs, J.M., Nichols, R.C., Trask, H.W., Wrighton, S.A., Sinclair, P.R., Sinclair, J.F. Biochem. Biophys. Res. Commun. (2005)
- Structure and expression of the rat CYP3A1 gene: isolation of the gene (P450/6betaB) and characterization of the recombinant protein. Nagata, K., Ogino, M., Shimada, M., Miyata, M., Gonzalez, F.J., Yamazoe, Y. Arch. Biochem. Biophys. (1999)
- Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes. Kalgutkar, A.S., Hatch, H.L., Kosea, F., Nguyen, H.T., Choo, E.F., McClure, K.F., Taylor, T.J., Henne, K.R., Kuperman, A.V., Dombroski, M.A., Letavic, M.A. Biopharmaceutics & drug disposition. (2006)
- An evaluation of para toluene-sulfonamide metabolism and effect with regard to CYP isoforms, P-glycoprotein, and drug interactions. Zhou, J.Q., Tang, Z.Q., Zhang, J.N. Die Pharmazie. (2006)
- 7-ketocholesterol is an endogenous modulator for the arylhydrocarbon receptor. Savouret, J.F., Antenos, M., Quesne, M., Xu, J., Milgrom, E., Casper, R.F. J. Biol. Chem. (2001)
- Selective induction of intestinal CYP3A23 by 1alpha,25-dihydroxyvitamin D3 in rats. Xu, Y., Iwanaga, K., Zhou, C., Cheesman, M.J., Farin, F., Thummel, K.E. Biochem. Pharmacol. (2006)
- Phenobarbital induction of CYP2B1/2 in primary hepatocytes: endocrine regulation and evidence for a single pathway for multiple inducers. Ganem, L.G., Trottier, E., Anderson, A., Jefcoate, C.R. Toxicol. Appl. Pharmacol. (1999)
- Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan). Baldwin, S.J., Bramhall, J.L., Ashby, C.A., Yue, L., Murdock, P.R., Hood, S.R., Ayrton, A.D., Clarke, S.E. Drug Metab. Dispos. (2006)
- Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. McKim, J.M., Wilga, P.C., Kolesar, G.B., Choudhuri, S., Madan, A., Dochterman, L.W., Breen, J.G., Parkinson, A., Mast, R.W., Meeks, R.G. Toxicol. Sci. (1998)
- Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner. Ganem, L.G., Jefcoate, C.R. Toxicol. Appl. Pharmacol. (1998)
- Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Mahnke, A., Strotkamp, D., Roos, P.H., Hanstein, W.G., Chabot, G.G., Nef, P. Arch. Biochem. Biophys. (1997)
- cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. Sidhu, J.S., Omiecinski, C.J. J. Biol. Chem. (1995)
- Dietary Inulin Alleviates Hepatic Steatosis and Xenobiotics-Induced Liver Injury in Rats Fed a High-Fat and High-Sucrose Diet: Association with the Suppression of Hepatic Cytochrome P450 and Hepatocyte Nuclear Factor 4{alpha} Expression. Sugatani, J., Wada, T., Osabe, M., Yamakawa, K., Yoshinari, K., Miwa, M. Drug Metab. Dispos. (2006)
- Induction of hepatic cytochrome P450 isozymes, benzo(a)pyrene metabolism and DNA binding following exposure to polycyclic aromatic hydrocarbon residues generated during repeated fish fried oil in rats. Pandey, M.K., Yadav, S., Parmar, D., Das, M. Toxicol. Appl. Pharmacol. (2006)
- Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy. Chen, L., Waxman, D.J. Cancer Res. (1995)
- Cellular dedifferentiation of endothelium is linked to activation and silencing of certain nuclear transcription factors: implications for endothelial dysfunction and vascular biology. Thum, T., Haverich, A., Borlak, J. FASEB J. (2000)