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Gene Review

Cyp3a13  -  cytochrome P450, family 3, subfamily a,...

Mus musculus

Synonyms: CYPIIIA13, Cyp3a-13, Cytochrome P450 3A13, IIIAm2, steroid inducible
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Disease relevance of Cyp3a13


High impact information on Cyp3a13

  • Transfection of the steroid-inducible LTR-C3 gene into unresponsive S115 mouse mammary tumor cells results in full inducibility of that gene with both androgen and glucocorticoid [3].
  • Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown [4].
  • To explore the biological significance of this observation, we placed a cDNA encoding Gs alpha in an expression vector under the control of a steroid-inducible promoter and isolated colonies of stably transfected C2C12 myoblasts [5].
  • Addition of dexamethasone to myoblasts bearing steroid-inducible ras oncogenes prevented myotube formation and induction of muscle creatine kinase and acetylcholine receptors [6].
  • In the presence of dexamethasone, myoblasts bearing steroid-inducible ras genes retained their dependence on exogenous growth factors to divide and exhibited contact inhibition of growth at confluent densities, indicating that the inhibitory effects of ras on differentiation were independent of cell proliferation [6].

Chemical compound and disease context of Cyp3a13


Biological context of Cyp3a13


Anatomical context of Cyp3a13

  • Thus, CBD appears to inactivate the P-450IIIA isozymes that are constitutively present in hepatic microsomes of untreated mice and/or inducible by phenobarbital pretreatment but not those that are steroid inducible [8].
  • When Cyp3a-13 cDNA was expressed in CR119 cells which had been established as a cell line stably expressing NADPH-cytochrome P-450 reductase cDNA of guinea pigs, aflatoxin B1-dependent cytotoxicity was observed [9].
  • A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells [13].
  • We reported previously that in the human uterus, a composite organ in which fibroblast, epithelial, and smooth muscle cells are the major constituents, an inverse relationship exists between the levels of PGF2alpha and a steroid-inducible anti-inflammatory protein, uteroglobin [14].
  • BACKGROUND: Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown [15].

Associations of Cyp3a13 with chemical compounds


Other interactions of Cyp3a13


Analytical, diagnostic and therapeutic context of Cyp3a13


  1. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cordingley, M.G., Riegel, A.T., Hager, G.L. Cell (1987) [Pubmed]
  2. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Wright, W.E., Pereira-Smith, O.M., Shay, J.W. Mol. Cell. Biol. (1989) [Pubmed]
  3. Progression to steroid insensitivity can occur irrespective of the presence of functional steroid receptors. Darbre, P.D., King, R.J. Cell (1987) [Pubmed]
  4. Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin. Zhang, Z., Kundu, G.C., Yuan, C.J., Ward, J.M., Lee, E.J., DeMayo, F., Westphal, H., Mukherjee, A.B. Science (1997) [Pubmed]
  5. Expression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells. Tsai, C.C., Saffitz, J.E., Billadello, J.J. J. Clin. Invest. (1997) [Pubmed]
  6. Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes. Gossett, L.A., Zhang, W., Olson, E.N. J. Cell Biol. (1988) [Pubmed]
  7. Steroid hormone receptor status defines the MMTV promoter chromatin structure in vivo. Archer, T.K., Fryer, C.J., Lee, H.L., Zaniewski, E., Liang, T., Mymryk, J.S. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  8. Selective inactivation of mouse liver cytochrome P-450IIIA by cannabidiol. Bornheim, L.M., Correia, M.A. Mol. Pharmacol. (1990) [Pubmed]
  9. Molecular cloning and functional expression of a mouse cytochrome P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate aflatoxin B1 (AFB1). Yanagimoto, T., Itoh, S., Sawada, M., Hashimoto, H., Kamataki, T. Biochim. Biophys. Acta (1994) [Pubmed]
  10. DUB-1, a deubiquitinating enzyme with growth-suppressing activity. Zhu, Y., Carroll, M., Papa, F.R., Hochstrasser, M., D'Andrea, A.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  11. Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase. Tseng, A., Lee, W.M., Jakobovits, E.B., Kirsten, E., Hakam, A., McLick, J., Buki, K., Kun, E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  12. Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation. Holt, J.T., Gopal, T.V., Moulton, A.D., Nienhuis, A.W. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  13. A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells. Mader, S., White, J.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  14. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. Mandal, A.K., Ray, R., Zhang, Z., Chowdhury, B., Pattabiraman, N., Mukherjee, A.B. J. Biol. Chem. (2005) [Pubmed]
  15. Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. Hung, C.H., Chen, L.C., Zhang, Z., Chowdhury, B., Lee, W.L., Plunkett, B., Chen, C.H., Myers, A.C., Huang, S.K. J. Allergy Clin. Immunol. (2004) [Pubmed]
  16. Mouse cytochrome P450 (Cyp3a11): predominant expression in liver and capacity to activate aflatoxin B1. Yanagimoto, T., Itoh, S., Sawada, M., Kamataki, T. Arch. Biochem. Biophys. (1997) [Pubmed]
  17. Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation. Chung, F.Z., Wang, C.D., Potter, P.C., Venter, J.C., Fraser, C.M. J. Biol. Chem. (1988) [Pubmed]
  18. Inducible, high-level production of infectious murine leukemia retroviral vector particles pseudotyped with vesicular stomatitis virus G envelope protein. Yang, Y., Vanin, E.F., Whitt, M.A., Fornerod, M., Zwart, R., Schneiderman, R.D., Grosveld, G., Nienhuis, A.W. Hum. Gene Ther. (1995) [Pubmed]
  19. Suppression of phagocytosis by dexamethasone in macrophage cultures: inability of arachidonic acid, indomethacin, and nordihydroguaiaretic acid to reverse the inhibitory response mediated by a steroid-inducible factor. Becker, J., Grasso, R.J. Int. J. Immunopharmacol. (1985) [Pubmed]
  20. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein. Chen, L.C., Zhang, Z., Myers, A.C., Huang, S.K. J. Immunol. (2001) [Pubmed]
  21. Alteration of phosphoinositide metabolism by attenuation of cAMP resulting from expression of the H-ras oncogene. Murphy, S.K., Lindberg, J.B., Prussack, D.A. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
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