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MeSH Review

Synaptic Membranes

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Disease relevance of Synaptic Membranes


Psychiatry related information on Synaptic Membranes


High impact information on Synaptic Membranes

  • Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an inability to retrieve synaptic membrane [11].
  • Dynamin- and clathrin-coated intermediates may form independently of each other, despite the coupling between the two processes typically observed in synaptic membranes [12].
  • NSF's synaptic membrane substrate, the ternary SNARE complex containing syntaxin, SNAP-25, and synaptobrevin, is a 4 x 14 nm rod with a "tail" at one end, corresponding to the N-terminus of syntaxin [13].
  • RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion [14].
  • These results, taken together with those of Richards and Hesketh, suggest that the effect of alphaxalone may be mediated by interactions with synaptic membranes that are more specific than simply a generalized change in membrane structure, and that these interactions are affected by sex steroids [15].

Chemical compound and disease context of Synaptic Membranes


Biological context of Synaptic Membranes


Anatomical context of Synaptic Membranes


Associations of Synaptic Membranes with chemical compounds


Gene context of Synaptic Membranes

  • ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma [32].
  • These findings suggest that Mpp4 coordinates Psd95/Veli3 assembly and maintenance at synaptic membranes [33].
  • Single-channel recordings revealed the presence in synaptic membranes of three different potassium channel types (A2, KD, KL), with biophysical properties that could account for the macroscopic currents and resemble those of the Shal, Shab, and Shaw channels described in heterologous expression systems and Drosophila neuronal somata [34].
  • These results suggest that the NR1 subunit is modified when it is incorporated into the synaptic membrane, possibly by strengthening its interaction with NR2 or another synaptic protein [35].
  • Treatment of rat brain slices with Tat-H-Ras depleted NR2A from the synaptic membrane, decreased endogenous Src activity and NR2A phosphorylation, and decreased the magnitude of hippocampal LTP [36].

Analytical, diagnostic and therapeutic context of Synaptic Membranes


  1. Overestimation of serum concentrations of gamma-aminobutyric acid in patients with hepatic encephalopathy by the gamma-aminobutyric acid-radioreceptor assay. Ferenci, P., Ebner, J., Zimmermann, C., Kikuta, C., Roth, E., Häussinger, D. Hepatology (1988) [Pubmed]
  2. Changes in glutamate receptors on synaptic membranes associated with hepatic encephalopathy or hyperammonemia in the rabbit. Ferenci, P., Pappas, S.C., Munson, P.J., Jones, E.A. Hepatology (1984) [Pubmed]
  3. Autoimmunity in stiff-Man syndrome with breast cancer is targeted to the C-terminal region of human amphiphysin, a protein similar to the yeast proteins, Rvs167 and Rvs161. David, C., Solimena, M., De Camilli, P. FEBS Lett. (1994) [Pubmed]
  4. Ammodytoxin A acceptor in bovine brain synaptic membranes. Krizaj, I., Rowan, E.G., Gubensek, F. Toxicon (1995) [Pubmed]
  5. The synaptic membrane D2-protein in amniotic fluid from pregnancies with fetal neural tube defects. Jørgensen, O.S., Nørgaard-Pedersen, B. Prenat. Diagn. (1981) [Pubmed]
  6. Classical conditioning of the rabbit eyelid response increases glutamate receptor binding in hippocampal synaptic membranes. Mamounas, L.A., Thompson, R.F., Lynch, G., Baudry, M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  7. Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. Ozawa, H., Rasenick, M.M. J. Neurochem. (1991) [Pubmed]
  8. Influence of morphine dependence on GABA-stimulated benzodiazepine binding to mouse brain synaptic membranes. Sivam, S.P., Ho, I.K. Eur. J. Pharmacol. (1982) [Pubmed]
  9. Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease. Cowburn, R.F., Vestling, M., Fowler, C.J., Ravid, R., Winblad, B., O'Neill, C. Neurosci. Lett. (1993) [Pubmed]
  10. Antibrain antibodies in mental disorder: no evidence for antibodies against synaptic membranes. Schott, K., Batra, A., Richartz, E., Sarkar, R., Günthner, A., Bartels, M., Buchkremer, G. Journal of neural transmission (Vienna, Austria : 1996) (1998) [Pubmed]
  11. Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Verstreken, P., Kjaerulff, O., Lloyd, T.E., Atkinson, R., Zhou, Y., Meinertzhagen, I.A., Bellen, H.J. Cell (2002) [Pubmed]
  12. Generation of coated intermediates of clathrin-mediated endocytosis on protein-free liposomes. Takei, K., Haucke, V., Slepnev, V., Farsad, K., Salazar, M., Chen, H., De Camilli, P. Cell (1998) [Pubmed]
  13. Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy. Hanson, P.I., Roth, R., Morisaki, H., Jahn, R., Heuser, J.E. Cell (1997) [Pubmed]
  14. RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. Geppert, M., Südhof, T.C. Annu. Rev. Neurosci. (1998) [Pubmed]
  15. Sex difference in response to alphaxalone anaesthesia may be oestrogen dependent. Fink, G., Sarkar, D.K., Dow, R.C., Dick, H., Borthwick, N., Malnick, S., Twine, M. Nature (1982) [Pubmed]
  16. Effects of electroshock and drugs administered in vivo on protein kinase activity in rat brain. Holmes, H., Rodnight, R., Kapoor, R. Pharmacol. Biochem. Behav. (1977) [Pubmed]
  17. Stereospecific action of pyrethroid insecticides on the gamma-aminobutyric acid receptor-ionophore complex. Lawrence, L.J., Casida, J.E. Science (1983) [Pubmed]
  18. Ca2+ and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue. Sieghart, W., Forn, J., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  19. Solubilization of the apamin receptor associated with a calcium-activated potassium channel from rat brain. Seagar, M.J., Marqueze, B., Couraud, F. J. Neurosci. (1987) [Pubmed]
  20. Proteolytic conversion of [Met]enkephalin-Arg6-Gly7-Leu8 by brain synaptic membranes. Characterization of formed peptides and mechanism of proteolysis. Norman, J.A., Chang, J.Y. J. Biol. Chem. (1985) [Pubmed]
  21. The metabolism of neuropeptides. Neurokinin A (substance K) is a substrate for endopeptidase-24.11 but not for peptidyl dipeptidase A (angiotensin-converting enzyme). Hooper, N.M., Kenny, A.J., Turner, A.J. Biochem. J. (1985) [Pubmed]
  22. The biochemistry of memory: a new and specific hypothesis. Lynch, G., Baudry, M. Science (1984) [Pubmed]
  23. Functional exchange of components between light-activated photoreceptor phosphodiesterase and hormone-activated adenylate cyclase systems. Bitensky, M.W., Wheeler, M.A., Rasenick, M.M., Yamazaki, A., Stein, P.J., Halliday, K.R., Wheeler, G.L. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  24. Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli. Matsas, R., Fulcher, I.S., Kenny, A.J., Turner, A.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  25. Intrinsic GABAergic system of adrenal chromaffin cells. Kataoka, Y., Gutman, Y., Guidotti, A., Panula, P., Wroblewski, J., Cosenza-Murphy, D., Wu, J.Y., Costa, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  26. Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein. Ueda, T., Greengard, P. J. Biol. Chem. (1977) [Pubmed]
  27. 3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABA B sites in rat brain. Hill, D.R., Bowery, N.G. Nature (1981) [Pubmed]
  28. Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes. Yoneda, Y., Kuriyama, K. Nature (1980) [Pubmed]
  29. Interaction of a fluorescent probe with acetylcholine-activated synaptic membrane. Adams, P.R., Feltz, A. Nature (1977) [Pubmed]
  30. Micromolar calcium stimulates proteolysis and glutamate binding in rat brain synaptic membranes. Baudry, M., Bundman, M.C., Smith, E.K., Lynch, G.S. Science (1981) [Pubmed]
  31. A major metabolite of arginine vasopressin in the brain is a highly potent neuropeptide. Burbach, J.P., Kovács, G.L., de Wied, D., van Nispen, J.W., Greven, H.M. Science (1983) [Pubmed]
  32. ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. Krauss, M., Kinuta, M., Wenk, M.R., De Camilli, P., Takei, K., Haucke, V. J. Cell Biol. (2003) [Pubmed]
  33. Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse. Aartsen, W.M., Kantardzhieva, A., Klooster, J., van Rossum, A.G., van de Pavert, S.A., Versteeg, I., Cardozo, B.N., Tonagel, F., Beck, S.C., Tanimoto, N., Seeliger, M.W., Wijnholds, J. Hum. Mol. Genet. (2006) [Pubmed]
  34. Presynaptic recordings from Drosophila: correlation of macroscopic and single-channel K+ currents. Martínez-Padrón, M., Ferrús, A. J. Neurosci. (1997) [Pubmed]
  35. Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits. Blahos, J., Wenthold, R.J. J. Biol. Chem. (1996) [Pubmed]
  36. H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. Thornton, C., Yaka, R., Dinh, S., Ron, D. J. Biol. Chem. (2003) [Pubmed]
  37. Effect of protein and lactulose on the production of gamma-aminobutyric acid by faecal Escherichia coli. al Mardini, H., al Jumaili, B., Record, C.O., Burke, D. Gut (1991) [Pubmed]
  38. A membrane-associated GDP/GTP exchange protein specific for Rho small GTP-binding protein - partial purification and characterization from rat brain. Matsuda, S., Nakanishi, H., Sasaki, T., Takai, Y. Oncogene (1996) [Pubmed]
  39. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. Sze, C.I., Troncoso, J.C., Kawas, C., Mouton, P., Price, D.L., Martin, L.J. J. Neuropathol. Exp. Neurol. (1997) [Pubmed]
  40. Characterization of calpain-mediated proteolysis of GluR1 subunits of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors in rat brain. Bi, X., Chen, J., Dang, S., Wenthold, R.J., Tocco, G., Baudry, M. J. Neurochem. (1997) [Pubmed]
  41. Interaction of strychnine-insensitive glycine binding with MK-801 binding in brain synaptic membranes. Yoneda, Y., Ogita, K., Suzuki, T. J. Neurochem. (1990) [Pubmed]
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