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MeSH Review

Synaptic Membranes

 
 
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Disease relevance of Synaptic Membranes

 

Psychiatry related information on Synaptic Membranes

 

High impact information on Synaptic Membranes

  • Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an inability to retrieve synaptic membrane [11].
  • Dynamin- and clathrin-coated intermediates may form independently of each other, despite the coupling between the two processes typically observed in synaptic membranes [12].
  • NSF's synaptic membrane substrate, the ternary SNARE complex containing syntaxin, SNAP-25, and synaptobrevin, is a 4 x 14 nm rod with a "tail" at one end, corresponding to the N-terminus of syntaxin [13].
  • RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion [14].
  • These results, taken together with those of Richards and Hesketh, suggest that the effect of alphaxalone may be mediated by interactions with synaptic membranes that are more specific than simply a generalized change in membrane structure, and that these interactions are affected by sex steroids [15].
 

Chemical compound and disease context of Synaptic Membranes

 

Biological context of Synaptic Membranes

 

Anatomical context of Synaptic Membranes

 

Associations of Synaptic Membranes with chemical compounds

 

Gene context of Synaptic Membranes

  • ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma [32].
  • These findings suggest that Mpp4 coordinates Psd95/Veli3 assembly and maintenance at synaptic membranes [33].
  • Single-channel recordings revealed the presence in synaptic membranes of three different potassium channel types (A2, KD, KL), with biophysical properties that could account for the macroscopic currents and resemble those of the Shal, Shab, and Shaw channels described in heterologous expression systems and Drosophila neuronal somata [34].
  • These results suggest that the NR1 subunit is modified when it is incorporated into the synaptic membrane, possibly by strengthening its interaction with NR2 or another synaptic protein [35].
  • Treatment of rat brain slices with Tat-H-Ras depleted NR2A from the synaptic membrane, decreased endogenous Src activity and NR2A phosphorylation, and decreased the magnitude of hippocampal LTP [36].
 

Analytical, diagnostic and therapeutic context of Synaptic Membranes

References

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