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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dpy-2  -  Protein DPY-2

Caenorhabditis elegans

 
 
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Disease relevance of dpy-2

  • Thus, dwarfism mutations studied principally act via adult syncytial growth, with cell size being near normal in both dbl-1 and dpy-2 mutant worms [1].
 

High impact information on dpy-2

  • The genes do not, however, appear to be functionally redundant, because a dpy-10 null mutant is not rescued by the dpy-2 gene [2].
  • Mutations in cuticle collagen genes dpy-2, dpy-7, and dpy-10 cause a similar Osr Dec phenotype. osm-7 is expressed in the hypodermis and may be secreted [3].

References

  1. A novel mode of ecdysozoan growth in Caenorhabditis elegans. Knight, C.G., Patel, M.N., Azevedo, R.B., Leroi, A.M. Evol. Dev. (2002) [Pubmed]
  2. Molecular and genetic analyses of the Caenorhabditis elegans dpy-2 and dpy-10 collagen genes: a variety of molecular alterations affect organismal morphology. Levy, A.D., Yang, J., Kramer, J.M. Mol. Biol. Cell (1993) [Pubmed]
  3. Identification of a Novel Gene Family Involved in Osmotic Stress Response in Caenorhabditis elegans. Wheeler, J.M., Thomas, J.H. Genetics (2006) [Pubmed]
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