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Gene Review

dpy-2  -  Protein DPY-2

Caenorhabditis elegans

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Disease relevance of dpy-2

  • Thus, dwarfism mutations studied principally act via adult syncytial growth, with cell size being near normal in both dbl-1 and dpy-2 mutant worms [1].

High impact information on dpy-2

  • The genes do not, however, appear to be functionally redundant, because a dpy-10 null mutant is not rescued by the dpy-2 gene [2].
  • Mutations in cuticle collagen genes dpy-2, dpy-7, and dpy-10 cause a similar Osr Dec phenotype. osm-7 is expressed in the hypodermis and may be secreted [3].


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