Gene Review:
col-13 - Protein COL-13
Caenorhabditis elegans
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High impact information on collagen
- The major differences between the genes is that, preceding the initiator ATG, col-12 has a cis-spliced intron, while col-13 is transspliced [1].
- We have determined the complete nucleotide sequences of two collagen genes, col-12 and col-13, that are separated by only 1800 bases and are transcribed in the same direction [1].
Biological context of collagen
- The amino acid sequences are identical except for two conservative amino acid changes within the putative secretory signal sequences, so the mature forms of the col-12 and col-13 collagens would be identical [1].
- In contrast to the coding regions and the introns, the 5' and 3' flanking regions show little sequence similarity, col-12 and col-13 are expressed at similar levels at the same developmental stages, and appear to utilize conserved TATA boxes and transcription start sites [1].
- These results suggest that col-12 and col-13 are derived from a gene duplication and that sequence homology in the coding regions, but not in the flanking regions, has been maintained by gene conversion [1].
- We conclude that the gene duplication event that resulted in the creation of col-12 and col-13 in C. elegans is most likely the same duplication that generated colost-1 and colost-2 in O. circumcincta, and thus this particular gene duplication precedes the divergence of the two species [2].
References
- Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing. Park, Y.S., Kramer, J.M. J. Mol. Biol. (1990) [Pubmed]
- Cuticular collagen genes from the parasitic nematode Ostertagia circumcincta. Johnstone, I.L., Shafi, Y., Majeed, A., Barry, J.D. Mol. Biochem. Parasitol. (1996) [Pubmed]
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