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Gene Review

dpy-7  -  Protein DPY-7

Caenorhabditis elegans

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High impact information on dpy-7

  • This yielded a wild-type collagen gene clone which we showed, by micro-injection, could repair the dpy-7 mutant phenotype in transgenic animals [1].
  • We made use of the C. elegans physical map to screen specifically for collagen genes in the region of the X chromosome to which dpy-7 maps [1].
  • We cloned the homologous sequence from four dpy-7 mutant strains and by sequence analysis identified a single mutation in each case [1].
  • Assaying candidate gene expression in populations of animals treated with CHR3 (nhr-23) RNA-mediated interference has identified dpy-7 as a potential gene acting downstream of CHR3 [2].
  • We have investigated the cis regulatory requirements for tissue- and stage-specific expression of the cuticle collagen gene dpy-7 and have identified a compact regulatory element which is sufficient to specify hypodermal cell reporter gene expression [3].

Biological context of dpy-7

  • We have studied mutant alleles of the C. elegans dpy-7 gene, one of a large group of genes whose mutant phenotype is altered body form and several of which have previously been shown to encode cuticular collagens [1].
  • This element appears to be a true tissue-specific promoter element, since it encompasses the dpy-7 transcription initiation sites and functions in an orientation-dependent manner [3].

Anatomical context of dpy-7


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