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Gene Review

col-12  -  Protein COL-12

Caenorhabditis elegans

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High impact information on collagen

  • The major differences between the genes is that, preceding the initiator ATG, col-12 has a cis-spliced intron, while col-13 is transspliced [1].
  • We have determined the complete nucleotide sequences of two collagen genes, col-12 and col-13, that are separated by only 1800 bases and are transcribed in the same direction [1].
  • Homology in the flanking sequence has allowed us to unambiguously identify this gene as the col-12 homologue, as opposed to some other closely related member of this large multigene family [2].

Biological context of collagen


  1. Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing. Park, Y.S., Kramer, J.M. J. Mol. Biol. (1990) [Pubmed]
  2. Conservation of the Caenorhabditis elegans cuticle collagen gene col-12 in Caenorhabditis briggsae. Gilleard, J.S., Henderson, D.K., Ulla, N. Gene (1997) [Pubmed]
  3. Cuticular collagen genes from the parasitic nematode Ostertagia circumcincta. Johnstone, I.L., Shafi, Y., Majeed, A., Barry, J.D. Mol. Biochem. Parasitol. (1996) [Pubmed]
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