Disease relevance of Mpp1

• Data from clinical trails have shown that the antitumoral effect of ONYX-015, an E1B 55kDa-deficient adenovirus, as monotherapy is insufficient [1].

High impact information on Mpp1

• Mpp1 is ubiquitously expressed and encodes a p55 protein of 466 amino acids with 93 and 65% identity to the human and puffer fish (Fugu rubripes) p55 sequences, respectively [2].
• The location of the Mpp1 gene, on the X chromosome, is also conserved between the human and the mouse [2].
• Conservation of the Mpp1 gene between mouse and human gives support to the notion that construction and study of a mouse knockout model may help establish the function of the human MPP1 gene, a potential tumor suppressor gene [2].
• As a first step toward studying the effects of mutations in this gene in a mammalian system, the nucleotide sequence of the mouse Mpp1 cDNA has been determined along with the intron-exon boundaries [2].
• The genomic structure of the Mpp1 gene is likewise conserved with 12 exons [2].

Anatomical context of Mpp1

• Surprisingly, three SREBP2 immunoreactive proteins (72, 63 and 55kDa), that are not present in mouse liver nuclei, reside in testis nuclei of prepubertal and adult mice [3].
• By Western blot analysis, intense positive bands were seen at the predicted molecular mass (about 55kDa) in all the major salivary glands, while an approximately 30kDa band of osteopontin was detected only in the submandibular gland [4].

Associations of Mpp1 with chemical compounds

• Sequencing of a 55kDa band co-eluting with the enzymatic activity in the last step indicated that it corresponded to aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme known to catalyze the oxidation of retinaldehyde to retinoic acid [5].

Other interactions of Mpp1

• Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome [6].
• The 55kDa protein is likely SREBP2gc, the other two isoforms are novel [3].

Analytical, diagnostic and therapeutic context of Mpp1

• In both groups, Western-blot analysis revealed the presence of aromatase protein as a single band of approximately 55kDa [7].

References