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Gene Review

Mpp1  -  membrane protein, palmitoylated

Mus musculus

Synonyms: 55 kDa erythrocyte membrane protein, 55kDa, C130070C03Rik, Membrane protein, palmitoylated 1, erythrocyte protein p55, ...
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Disease relevance of Mpp1

  • Data from clinical trails have shown that the antitumoral effect of ONYX-015, an E1B 55kDa-deficient adenovirus, as monotherapy is insufficient [1].

High impact information on Mpp1

  • Mpp1 is ubiquitously expressed and encodes a p55 protein of 466 amino acids with 93 and 65% identity to the human and puffer fish (Fugu rubripes) p55 sequences, respectively [2].
  • The location of the Mpp1 gene, on the X chromosome, is also conserved between the human and the mouse [2].
  • Conservation of the Mpp1 gene between mouse and human gives support to the notion that construction and study of a mouse knockout model may help establish the function of the human MPP1 gene, a potential tumor suppressor gene [2].
  • As a first step toward studying the effects of mutations in this gene in a mammalian system, the nucleotide sequence of the mouse Mpp1 cDNA has been determined along with the intron-exon boundaries [2].
  • The genomic structure of the Mpp1 gene is likewise conserved with 12 exons [2].

Anatomical context of Mpp1


Associations of Mpp1 with chemical compounds

  • Sequencing of a 55kDa band co-eluting with the enzymatic activity in the last step indicated that it corresponded to aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme known to catalyze the oxidation of retinaldehyde to retinoic acid [5].

Other interactions of Mpp1


Analytical, diagnostic and therapeutic context of Mpp1

  • In both groups, Western-blot analysis revealed the presence of aromatase protein as a single band of approximately 55kDa [7].


  1. Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma. Li, G., Sham, J., Yang, J., Su, C., Xue, H., Chua, D., Sun, L., Zhang, Q., Cui, Z., Wu, M., Qian, Q. Int. J. Cancer (2005) [Pubmed]
  2. cDNA sequence and genomic structure of the murine p55 (Mpp1) gene. Elder, B., Kuo, K., Gitschier, J., Kim, A., Chishti, A., Metzenberg, A. Genomics (1996) [Pubmed]
  3. Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation. Fon Tacer, K., Kalanj-Bognar, S., Waterman, M.R., Rozman, D. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  4. The expression and localization of osteopontin in the mouse major salivary glands. Asaka, M., Ohta, K., Muramatsu, T., Kurokawa, M., Kizaki, H., Hashimoto, S., Shimono, M. Arch. Histol. Cytol. (2006) [Pubmed]
  5. Identification of 3-deoxyglucosone dehydrogenase as aldehyde dehydrogenase 1A1 (retinaldehyde dehydrogenase 1). Collard, F., Vertommen, D., Fortpied, J., Duester, G., Van Schaftingen, E. Biochimie (2007) [Pubmed]
  6. Localization of the gene encoding the erythrocyte membrane protein p55 (Mpp1) on the mouse X Chromosome. Peters, L.L., Kirley, L.A., Kim, A.C., Chishti, A.H. Mamm. Genome (1996) [Pubmed]
  7. Testicular morphology and expression of aromatase in testes of mice with the mosaic mutation (Atp7a(mo-ms)). Kotula-Balak, M., Lenartowicz, M., Kowal, M., Styrna, J., Bili??ska, B. Theriogenology (2007) [Pubmed]
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