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Gene Review

Srebf2  -  sterol regulatory element binding factor 2

Mus musculus

Synonyms: AI608257, SREBP-2, SREBP2, SREBP2gc, Srebp2, ...
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High impact information on Srebf2


Biological context of Srebf2


Anatomical context of Srebf2

  • Our RT-PCR results also show that SREBP2 as well as SREBP1c mRNAs are detectable in prepubertal and postpubertal male germ cells while SREBP1a is not detected [9].
  • We further show that the amount of nuclear SREBP-2 protein also increases despite no increase in SREBP-2 mRNA, suggesting that proteolytic cleavage of SREBPs is induced in lipid loaded adipocytes [10].
  • Surprisingly, three SREBP2 immunoreactive proteins (72, 63 and 55kDa), that are not present in mouse liver nuclei, reside in testis nuclei of prepubertal and adult mice [9].
  • SREBP2gc is selectively enriched in spermatocytes and spermatids, and, due to its novel structure, its synthesis is not subject to cholesterol feedback control [8].
  • Suppression of ABCG1 expression increased cholesteryl ester formation and decreased SREBP2 target gene expression in macrophages, even in the absence of HDL acceptors [11].

Associations of Srebf2 with chemical compounds


Regulatory relationships of Srebf2

  • These results demonstrate that SREBP-2 appears to promote adipocyte differentiation as well as SREBP-1 and that the proteolytic activation of SREBPs may be induced by an as-yet unidentified mechanism in lipid loaded adipocytes [10].
  • Abnormal regulation of SREBP2 appears to be responsible for the failure to suppress cholesterol synthesis in genetically cholesterol gallstone-susceptible mice [15].

Other interactions of Srebf2

  • Northern blot analysis of the livers from transgenic mice demonstrated that this gene was highly induced by SREBP-1a, SREBP-1c, and SREBP-2 [16].
  • However, a near-complete suppression of nuclear SREBP2 related to low Hmgcr mRNA levels was noticed only for gallstone-resistant AKR mice [15].
  • The 55kDa protein is likely SREBP2gc, the other two isoforms are novel [9].
  • A total of 1,003 genes showed statistically significant increased expression in livers of transgenic SREBP-1a mice, 505 increased in livers of transgenic SREBP-2 mice, and 343 showed decreased expression in Scap-/- livers [17].
  • On the contrary, SREBP 2 mRNA quantities varied during the myelination period similarly to the lipogenic gene mRNAs, and the levels measured in trembler represented only 10% of the normal values [18].

Analytical, diagnostic and therapeutic context of Srebf2

  • Refeeding a high carbohydrate/low fat diet resulted in a 4- to 5-fold increase of nuclear SREBP-1 above nonfasted levels, whereas nuclear SREBP-2 protein returned only to the nonfasted level [19].


  1. Local regulation of fat metabolism in peripheral nerves. Verheijen, M.H., Chrast, R., Burrola, P., Lemke, G. Genes Dev. (2003) [Pubmed]
  2. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.M., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., Mangelsdorf, D.J. Genes Dev. (2000) [Pubmed]
  3. Disruption of cholesterol homeostasis by plant sterols. Yang, C., Yu, L., Li, W., Xu, F., Cohen, J.C., Hobbs, H.H. J. Clin. Invest. (2004) [Pubmed]
  4. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. Horton, J.D., Shimomura, I., Brown, M.S., Hammer, R.E., Goldstein, J.L., Shimano, H. J. Clin. Invest. (1998) [Pubmed]
  5. Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis. Amanna, I.J., Clise-Dwyer, K., Nashold, F.E., Hoag, K.A., Hayes, C.E. J. Immunol. (2001) [Pubmed]
  6. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. Park, S.W., Moon, Y.A., Horton, J.D. J. Biol. Chem. (2004) [Pubmed]
  7. SREBP transcription factors: master regulators of lipid homeostasis. Eberlé, D., Hegarty, B., Bossard, P., Ferré, P., Foufelle, F. Biochimie (2004) [Pubmed]
  8. Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression. Wang, H., San Agustin, J.T., Witman, G.B., Kilpatrick, D.L. Mol. Cell. Biol. (2004) [Pubmed]
  9. Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation. Fon Tacer, K., Kalanj-Bognar, S., Waterman, M.R., Rozman, D. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  10. Proteolytic activation of SREBPs during adipocyte differentiation. Inoue, J., Kumagai, H., Terada, T., Maeda, M., Shimizu, M., Sato, R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  11. LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL. Wang, N., Ranalletta, M., Matsuura, F., Peng, F., Tall, A.R. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
  12. Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease. Jiang, T., Liebman, S.E., Lucia, M.S., Li, J., Levi, M. Kidney Int. (2005) [Pubmed]
  13. Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy. Rampler, H., Weinhofer, I., Netik, A., Forss-Petter, S., Brown, P.J., Oplinger, J.A., Bugaut, M., Berger, J. Mol. Genet. Metab. (2003) [Pubmed]
  14. Cyclosporin-induced dyslipoproteinemia is associated with selective activation of SREBP-2. Wu, J., Zhu, Y.H., Patel, S.B. Am. J. Physiol. (1999) [Pubmed]
  15. Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice. Xu, G., Müller, O., Stange, E.F., Fuchs, M. Biochim. Biophys. Acta (2004) [Pubmed]
  16. Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status. Sone, H., Shimano, H., Sakakura, Y., Inoue, N., Amemiya-Kudo, M., Yahagi, N., Osawa, M., Suzuki, H., Yokoo, T., Takahashi, A., Iida, K., Toyoshima, H., Iwama, A., Yamada, N. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  17. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Horton, J.D., Shah, N.A., Warrington, J.A., Anderson, N.N., Park, S.W., Brown, M.S., Goldstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  18. Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination. Salles, J., Sargueil, F., Knoll-Gellida, A., Witters, L.A., Cassagne, C., Garbay, B. Biochim. Biophys. Acta (2003) [Pubmed]
  19. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Horton, J.D., Bashmakov, Y., Shimomura, I., Shimano, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
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