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Gene Review

nuc-1  -  Protein NUC-1

Caenorhabditis elegans

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Disease relevance of nuc-1


High impact information on nuc-1


Biological context of nuc-1


Anatomical context of nuc-1

  • F2-P3E3 staining is present within LMP-1::GFP labeled organelles in the intestinal primordium and is coincident with persistent DNA that has been phagocytosed in nuc-1(-) embryos, suggesting that it labels phagosomes [8].
  • As expected, expression of a dnase II-RNAi construct in flies resulted in a dramatic reduction of DNase II activity and a significant decrease in total hemocyte numbers [9].

Other interactions of nuc-1

  • Subsequent analysis of crude C. elegans protein extracts revealed that wild-type animals contained a potent endonuclease activity with a cleavage preference similar to DNase II, while nuc-1 mutant worms demonstrated a marked reduction in this nuclease activity [5].

Analytical, diagnostic and therapeutic context of nuc-1

  • Sequence analysis of C07B5.5 DNA and mRNA also revealed that nuc-1(e1392), but not wild-type animals contained a nonsense mutation within the CO7B5.5 coding region [5].
  • In this report, we describe the molecular cloning and characterization of DLAD, a novel mammalian deoxy-ribonuclease homologous to DNase II [10].


  1. A family history of deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei. MacLea, K.S., Krieser, R.J., Eastman, A. Gene (2003) [Pubmed]
  2. NUC-1, a caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis. Wu, Y.C., Stanfield, G.M., Horvitz, H.R. Genes Dev. (2000) [Pubmed]
  3. The cloning and expression of human deoxyribonuclease II. A possible role in apoptosis. Krieser, R.J., Eastman, A. J. Biol. Chem. (1998) [Pubmed]
  4. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Ellis, R.E., Jacobson, D.M., Horvitz, H.R. Genetics (1991) [Pubmed]
  5. The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Lyon, C.J., Evans, C.J., Bill, B.R., Otsuka, A.J., Aguilera, R.J. Gene (2000) [Pubmed]
  6. DNase II: genes, enzymes and function. Evans, C.J., Aguilera, R.J. Gene (2003) [Pubmed]
  7. Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison with the genomic structure of the human and three C. elegans homologs. Krieser, R.J., Eastman, A. Gene (2000) [Pubmed]
  8. Characterization of a conserved apoptotic marker expressed in Caenorhabditis elegans phagocytic cells. Eisenhut, R.J., Knox, D., Hermann, G.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  9. DNase II deficiency impairs innate immune function in Drosophila. Seong, C.S., Varela-Ramirez, A., Aguilera, R.J. Cell. Immunol. (2006) [Pubmed]
  10. DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Shiokawa, D., Tanuma, S. Nucleic Acids Res. (1999) [Pubmed]
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