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Gene Review

lin-45  -  Protein LIN-45

Caenorhabditis elegans

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High impact information on lin-45


Biological context of lin-45


Associations of lin-45 with chemical compounds

  • A nematode homologue of mammalian raf family protein serine/threonine kinases has been cloned and found to be encoded by the lin-45 gene [8].

Other interactions of lin-45

  • We provide evidence that smg-7 is cotranscribed with the previously characterized gene lin-45 and show that null alleles of smg-7 confer a temperature-sensitive defect in NMD [9].
  • Consistent with its negative function, overexpressing sur-5 from an extragenic array partially suppresses the Multivulva phenotype of an activated let-60 ras mutation and causes synergistic phenotypes with a lin-45 raf mutation [10].
  • Drosophila MAP kinase kinase suppresses the vulvaless phenotype of lin-3, let-23 and lin-45 mutations in Caenorhabditis elegans [11].


  1. C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation. Han, M., Golden, A., Han, Y., Sternberg, P.W. Nature (1993) [Pubmed]
  2. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Kornfeld, K., Guan, K.L., Horvitz, H.R. Genes Dev. (1995) [Pubmed]
  3. Positive and negative regulation of Raf kinase activity and function by phosphorylation. Chong, H., Lee, J., Guan, K.L. EMBO J. (2001) [Pubmed]
  4. A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans. Rocheleau, C.E., Howard, R.M., Goldman, A.P., Volk, M.L., Girard, L.J., Sundaram, M.V. Genetics (2002) [Pubmed]
  5. Identification of a homeobox-containing gene located between lin-45 and unc-24 on chromosome IV in the nematode Caenorhabditis elegans. Naito, M., Kohara, Y., Kurosawa, Y. Nucleic Acids Res. (1992) [Pubmed]
  6. Identification of residues and domains of Raf important for function in vivo and in vitro. Harding, A., Hsu, V., Kornfeld, K., Hancock, J.F. J. Biol. Chem. (2003) [Pubmed]
  7. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Hsu, V., Zobel, C.L., Lambie, E.J., Schedl, T., Kornfeld, K. Genetics (2002) [Pubmed]
  8. Role of a raf proto-oncogene during Caenorhabditis elegans vulval development. Sternberg, P.W., Golden, A., Han, M. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1993) [Pubmed]
  9. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Cali, B.M., Kuchma, S.L., Latham, J., Anderson, P. Genetics (1999) [Pubmed]
  10. Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction. Gu, T., Orita, S., Han, M. Mol. Cell. Biol. (1998) [Pubmed]
  11. Drosophila MAP kinase kinase suppresses the vulvaless phenotype of lin-3, let-23 and lin-45 mutations in Caenorhabditis elegans. Koga, M., Ohshima, Y. Mech. Dev. (1995) [Pubmed]
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