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Gene Review

BRAF  -  v-raf murine sarcoma viral oncogene homolog B

Gallus gallus

Synonyms: C-RMIL, RMIL
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Disease relevance of BRAF


High impact information on BRAF

  • NR cell multiplication results from the frequent activation and subsequent retroviral transduction of two related serine/threonine protein kinases, the c-mil/c-raf or c-Rmil/B-raf genes [2].
  • c-Rmil is the cellular allele of the v-Rmil oncogene transduced during in vitro passaging of Rous-associated virus type 1 in chicken embryonic neuroretina (NR) cells [3].
  • Two c-Rmil cDNA species, resulting from an alternative splicing mechanism, were isolated from quail embryonic NR cDNA libraries [3].
  • Expression of these cDNAs in COS-1 cells leads to the synthesis of two proteins with apparent molecular weights of 93.5 and 95 kDa, recognized by an Rmil-specific antiserum [3].
  • We previously reported that serial passaging of Rous-associated virus type 1 in nondividing chicken embryo neuroretina cells leads to reproducible generation of acutely mitogenic retroviruses that transduced the catalytic domain of c-mil/c-raf or c-Rmil/B-raf [4].

Biological context of BRAF

  • c-Rmil is the cellular allele of the v-Rmil oncogene, transduced during in vitro passaging of Rous associated virus type 1 in chicken embryonic neuroretina (NR) cells [5].
  • We show that c-Rmil proteins are encoded by 19 exons lying within about 100 kbp of genomic DNA [5].
  • We recently reported that the avian c-Rmil gene encodes two proteins of 94 and 95 kDa, resulting from an alternative splicing mechanism [5].
  • The 3' ends of both viruses were generated by recombination between Rmil and env genes, involving partial sequence identity [6].

Associations of BRAF with chemical compounds


  1. Complete nucleotide sequence of IC10, a retrovirus containing the Rmil oncogene transduced in chicken neuroretina cells infected with avian retrovirus RAV-1. Eychène, A., Marx, M., Dezélée, P., Calothy, G. Nucleic Acids Res. (1989) [Pubmed]
  2. Characterization of a leucine zipper-containing protein identified by retroviral insertion in avian neuroretina cells. Proux, V., Provot, S., Felder-Schmittbuhl, M.P., Laugier, D., Calothy, G., Marx, M. J. Biol. Chem. (1996) [Pubmed]
  3. Quail neuroretina c-Rmil(B-raf) proto-oncogene cDNAs encode two proteins of 93.5 and 95 kDa resulting from alternative splicing. Eychène, A., Barnier, J.V., Dézélée, P., Marx, M., Laugier, D., Calogeraki, I., Calothy, G. Oncogene (1992) [Pubmed]
  4. Occurrence of alternatively spliced leader-delta onc-poly(A) transcripts in chicken neuroretina cells infected with Rous-associated virus type 1: implication in transduction of the c-mil/c-raf and c-Rmil/B-raf oncogenes. Felder, M.P., Laugier, D., Eychene, A., Calothy, G., Marx, M. J. Virol. (1993) [Pubmed]
  5. Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene. Calogeraki, I., Barnier, J.V., Eychene, A., Felder, M.P., Calothy, G., Marx, M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  6. Common mechanism of retrovirus activation and transduction of c-mil and c-Rmil in chicken neuroretina cells infected with Rous-associated virus type 1. Felder, M.P., Eychène, A., Barnier, J.V., Calogeraki, I., Calothy, G., Marx, M. J. Virol. (1991) [Pubmed]
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