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Gene Review

vit-6  -  Protein VIT-6

Caenorhabditis elegans

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High impact information on vit-6

  • We have produced strains carrying a synthetic fusion of parts of two vitellogenin genes, vit-2 and vit-6, integrated into the Caenorhabditis elegans genome [1].
  • Stable transgenic strains were isolated expressing a gene in which 69 nucleotides of a vit-5 intron, including the 3' splice site, were inserted into the 5' untranslated region of a vit-2/vit-6 fusion gene [2].
  • Screening of a genomic library with a probe to total poly(A+) RNA yielded three clones that hybridized more intensely than all others, and all three corresponded to a single gene homologous to C. elegans vit-6 [3].
  • We review recent experimental work aimed at testing the role of antioxidant genes within the conceptual framework of the free radical theory of ageing, as well as studies investigating the role of juvenile hormone, vitellogenin and telomeres as mediators of ageing in social insects [4].
  • After progesterone treatment (10(-7) M), the vit-5 and vit-6 were down-regulated and vit-1 up-regulated (3.59-fold) [5].

Biological context of vit-6


Associations of vit-6 with chemical compounds


  1. Alteration of Caenorhabditis elegans gene expression by targeted transformation. Broverman, S., MacMorris, M., Blumenthal, T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Insertion of part of an intron into the 5' untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene. Conrad, R., Thomas, J., Spieth, J., Blumenthal, T. Mol. Cell. Biol. (1991) [Pubmed]
  3. Comparison of a vitellogenin gene between two distantly related rhabditid nematode species. Winter, C.E., Penha, C., Blumenthal, T. Mol. Biol. Evol. (1996) [Pubmed]
  4. Social insects as a model to study the molecular basis of ageing. Keller, L., Jemielity, S. Exp. Gerontol. (2006) [Pubmed]
  5. Caenorhabditis elegans as an environmental monitor using DNA microarray analysis. Custodia, N., Won, S.J., Novillo, A., Wieland, M., Li, C., Callard, I.P. Ann. N. Y. Acad. Sci. (2001) [Pubmed]
  6. Regulation of vitellogenin gene expression in transgenic Caenorhabditis elegans: short sequences required for activation of the vit-2 promoter. MacMorris, M., Broverman, S., Greenspoon, S., Lea, K., Madej, C., Blumenthal, T., Spieth, J. Mol. Cell. Biol. (1992) [Pubmed]
  7. Vitellogenin motifs conserved in nematodes and vertebrates. Spieth, J., Nettleton, M., Zucker-Aprison, E., Lea, K., Blumenthal, T. J. Mol. Evol. (1991) [Pubmed]
  8. Analysis of the VPE sequences in the Caenorhabditis elegans vit-2 promoter with extrachromosomal tandem array-containing transgenic strains. MacMorris, M., Spieth, J., Madej, C., Lea, K., Blumenthal, T. Mol. Cell. Biol. (1994) [Pubmed]
  9. Regulated expression of a vitellogenin fusion gene in transgenic nematodes. Spieth, J., MacMorris, M., Broverman, S., Greenspoon, S., Blumenthal, T. Dev. Biol. (1988) [Pubmed]
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