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Gene Review:

dpy-20 - Protein DPY-20

Caenorhabditis elegans

Clark, D.V. et al., Fukushige, T. et al., Prasad, S.S. et al.

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High impact information on dpy-20

The objective of this paper was the identification and characterization of coding regions in four cosmids containing DNA from the interval between dpy-20 and unc-22 on linkage group IV [1].
Sequence analysis of dpy-20 revealed that it was not similar to other genes encoding known cuticle components such as collagen or cuticulin [2].
Cosmid DNA containing the dpy-20 gene was successfully used to rescue the mutant phenotype of animals homozygous for another dpy-20 allele, e1282ts [2].
Sequence analysis of the putative dpy-20 homologue in Caenorhabditis briggsae was performed to confirm identification of the coding regions of the C. elegans gene and to identify conserved regulatory regions [2].
Effect of the dpy-20 and rol-6 cotransformation markers on alpha-tubulin gene expression in C. elegans transformants [3].

Biological context of dpy-20

Similar down-regulation in the ventral cord motor neurons was observed when the alpha-2 tubulin::lacZ fusion gene construct was tested in these experiments using the dpy-20 marker [3].
The dpy-20 marked-mediated suppression of the alpha-1 tubulin gene expression was observed both in the cis and trans configurations [3].

Anatomical context of dpy-20

In contrast, for the dpy-20 marker system, not only were fewer neurons stained in the head and tail region, but also the staining of ventral cord motor neurons was extremely reduced both in number and intensity [3].

Analytical, diagnostic and therapeutic context of dpy-20

Northern blot analysis showed that dpy-20 is expressed predominantly in the second larval stage and that the mRNA is not at all abundant [2].
Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans [2].

References

Evolutionarily conserved coding sequences in the dpy-20-unc-22 region of Caenorhabditis elegans. Prasad, S.S., Baillie, D.L. Genomics (1989) [Pubmed]
Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans. Clark, D.V., Suleman, D.S., Beckenbach, K.A., Gilchrist, E.J., Baillie, D.L. Mol. Gen. Genet. (1995) [Pubmed]
Effect of the dpy-20 and rol-6 cotransformation markers on alpha-tubulin gene expression in C. elegans transformants. Fukushige, T., Siddiqui, S.S. Transgenic Res. (1995) [Pubmed]

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