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Gene Review

Nfic  -  nuclear factor I/C

Mus musculus

Synonyms: 1110019L22Rik, 1500041O16Rik, AA589446, AI746521, CCAAT-box-binding transcription factor, ...
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High impact information on Nfic

  • The Nfic mutation is the first mutation described that affects primarily tooth root formation and should greatly aid our understanding of postnatal tooth development [1].
  • Heterozygous animals appear normal, whereas Nfic(-/-) mice have unique tooth pathologies: molars lacking roots, thin and brittle mandibular incisors, and weakened abnormal maxillary incisors [1].
  • Although Nfic is expressed in many organ systems, including the developing tooth, the tooth root development defects were the prominent phenotype [1].
  • The Psen1 C-terminal proteolytic fragment (CTF) is present at varying levels during embryogenesis, indicating the existence of developmental control mechanisms regulating its production [2].
  • APP C-terminal fragments (CTF) were markedly increased in both endoplasmic reticulum- (ER-) and Golgi-rich fractions of fibroblasts from KO mice; moreover, similar increases were documented directly in KO brain tissue [3].

Biological context of Nfic

  • It is most likely that this lactation/involution switch in NF1 factors represents a change in expression of NF1 C (CTF/NF1) proteins [4].
  • We further demonstrate that purified NFI-C protein will bind to this positive regulatory region within the hSMUG1 gene [5].

Anatomical context of Nfic


Associations of Nfic with chemical compounds

  • Erythromycin and azithromycin were macrolide antibiotics that markedly changed the cleavage of the APP C-Terminal Fragment (CTF) in SH-SY5Y cells [6].


  1. Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Steele-Perkins, G., Butz, K.G., Lyons, G.E., Zeichner-David, M., Kim, H.J., Cho, M.I., Gronostajski, R.M. Mol. Cell. Biol. (2003) [Pubmed]
  2. Developmental control of Presenilin1 expression, endoproteolysis, and interaction in zebrafish embryos. Nornes, S., Groth, C., Camp, E., Ey, P., Lardelli, M. Exp. Cell Res. (2003) [Pubmed]
  3. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Xia, W., Zhang, J., Ostaszewski, B.L., Kimberly, W.T., Seubert, P., Koo, E.H., Shen, J., Selkoe, D.J. Biochemistry (1998) [Pubmed]
  4. Transcription factor NF 1 expression in involuting mammary gland. Kane, R., Finlay, D., Lamb, T., Martin, F. Adv. Exp. Med. Biol. (2000) [Pubmed]
  5. The transcription factor, NFI/CTF plays a positive regulatory role in expression of the hSMUG1 gene. Elateri, I., Muller-Weeks, S., Caradonna, S. DNA Repair (Amst.) (2003) [Pubmed]
  6. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Tucker, S., Ahl, M., Cho, H.H., Bandyopadhyay, S., Cuny, G.D., Bush, A.I., Goldstein, L.E., Westaway, D., Huang, X., Rogers, J.T. Current Alzheimer research. (2006) [Pubmed]
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