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Gene Review

Ntn1  -  netrin 1

Rattus norvegicus

Synonyms: Netrin-1
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Disease relevance of Ntn1


High impact information on Ntn1

  • Floor plate cells at the ventral midline of the neural tube express a diffusible chemoattractant, netrin-1, that attracts a group of ventrally directed axons [2].
  • COS cells secreting recombinant netrin-1 mimic this effect, suggesting that netrin-1 is a bifunctional guidance cue that simultaneously attracts some axons to the floor plate while steering others away [2].
  • These results show that netrin-1 is a chemotropic factor expressed by floor plate cells and suggest that the two netrin proteins guide commissural axons in the developing spinal cord [3].
  • Ectopic expression of DCC produced a netrin-1-dependent increase in the number of filopodia and in cell surface area [4].
  • To determine whether netrin receptors (DCC, UNC5H1, UNC5H2) and netrin-1 are present in the adult rat retina and may affect regeneration of retinal ganglion cell (RGC) axons into peripheral nerve (PN) grafts, in situ hybridization (ISH) and immunostaining experiments were performed in normal and operated rats [5].

Biological context of Ntn1


Anatomical context of Ntn1

  • We show here that netrin-1 RNA is expressed by floor plate cells, whereas netrin-2 RNA is detected at lower levels in the ventral two-thirds of the spinal cord, but not the floor plate [3].
  • Netrin-1, a diffusible signal secreted by floor plate cells at the ventral midline of the vertebrate CNS, can attract ventrally migrating axons and repel a subset of dorsally migrating axons in the spinal cord and rostral hindbrain in vitro [11].
  • Netrin-1 expression was not found in the optic nerve head of adult rats, normal and postlesion, but appeared transiently at 7 and 14 days after PN grafting [5].
  • We show that the netrin-1 receptor, deleted in colorectal cancer (DCC), is present at filopodia tips in growth cones of embryonic rat spinal commissural neurons [4].
  • Explants from the ventral region of the caudal diencephalon where netrin-1 is expressed attracted the axons from habenular explants [12].

Associations of Ntn1 with chemical compounds

  • Our data demonstrated that glucose-induced aging in vitro caused an elongation and thickening of cell processes and significantly increased the expression of netrin reflecting a more mature state of oligodendrocyte development [13].

Other interactions of Ntn1

  • Here we show that the netrin receptors dcc, neogenin, unc5h1, unc5h2, and unc5h3 are also expressed in the adult rat spinal cord [7].
  • These results suggest that the growth of axons from the habenular nucleus along the neuromere boundary region may be regulated by Sema3F from the rostral p1, and netrin-1 from the ventral region of the caudal diencephalon [12].
  • In this study, we examined the spatio-temporal expression patterns of both netrin-1 and DCC in the rat olfactory system at different stages of development and during axonal regeneration following unilateral bulbectomy [6].

Analytical, diagnostic and therapeutic context of Ntn1


  1. Function of an axonal chemoattractant modulated by metalloprotease activity. Galko, M.J., Tessier-Lavigne, M. Science (2000) [Pubmed]
  2. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Colamarino, S.A., Tessier-Lavigne, M. Cell (1995) [Pubmed]
  3. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Kennedy, T.E., Serafini, T., de la Torre, J.R., Tessier-Lavigne, M. Cell (1994) [Pubmed]
  4. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Shekarabi, M., Kennedy, T.E. Mol. Cell. Neurosci. (2002) [Pubmed]
  5. Lesion-induced regulation of netrin receptors and modification of netrin-1 expression in the retina of fish and grafted rats. Petrausch, B., Jung, M., Leppert, C.A., Stuermer, C.A. Mol. Cell. Neurosci. (2000) [Pubmed]
  6. Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration. Astic, L., Pellier-Monnin, V., Saucier, D., Charrier, C., Mehlen, P. Neuroscience (2002) [Pubmed]
  7. Developmental shift in expression of netrin receptors in the rat spinal cord: predominance of UNC-5 homologues in adulthood. Manitt, C., Thompson, K.M., Kennedy, T.E. J. Neurosci. Res. (2004) [Pubmed]
  8. Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene. Yam, J.W., Chan, K.W., Ngan, E.S., Hsiao, W.L. Gene (2005) [Pubmed]
  9. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Tsim, T.Y., Wong, E.Y., Leung, M.S., Wong, C.C. Neuroscience (2004) [Pubmed]
  10. Developmental expression of DCC in the rat retina. Johansson, K., Törngren, M., Wasselius, J., Månsson, L., Ehinger, B. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  11. Guidance of circumferentially growing axons by netrin-dependent and -independent floor plate chemotropism in the vertebrate brain. Shirasaki, R., Mirzayan, C., Tessier-Lavigne, M., Murakami, F. Neuron (1996) [Pubmed]
  12. Axonal growth from the habenular nucleus along the neuromere boundary region of the diencephalon is regulated by semaphorin 3F and netrin-1. Funato, H., Saito-Nakazato, Y., Takahashi, H. Mol. Cell. Neurosci. (2000) [Pubmed]
  13. Exogenous application of glucose induces aging in rat cerebral oligodendrocytes as revealed by alteration in telomere length. Dabouras, V., Rothermel, A., Reininger-Mack, A., Wien, S.L., Layer, P.G., Robitzki, A.A. Neurosci. Lett. (2004) [Pubmed]
  14. Netrin-1 and peripheral nerve regeneration in the adult rat. Madison, R.D., Zomorodi, A., Robinson, G.A. Exp. Neurol. (2000) [Pubmed]
  15. Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells. Ellezam, B., Selles-Navarro, I., Manitt, C., Kennedy, T.E., McKerracher, L. Exp. Neurol. (2001) [Pubmed]
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